Ion Channels In Health And Disease
DOWNLOAD
Download Ion Channels In Health And Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Ion Channels In Health And Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Ion Channels In Health And Disease
DOWNLOAD
Author : Geoffrey S. Pitt
language : en
Publisher: Academic Press
Release Date : 2016-10-04
Ion Channels In Health And Disease written by Geoffrey S. Pitt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-04 with Science categories.
Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues
Textbook Of Ion Channels Volume Iii
DOWNLOAD
Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2023-06-28
Textbook Of Ion Channels Volume Iii written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-28 with Medical categories.
The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium–calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.
Handbook Of Ion Channels
DOWNLOAD
Author : Ji'e Zheng
language : en
Publisher: CRC Press
Release Date : 2016-10
Handbook Of Ion Channels written by Ji'e Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10 with categories.
The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channelsillustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.
Ion Channels And Disease
DOWNLOAD
Author : Frances M. Ashcroft
language : en
Publisher: Academic Press
Release Date : 1999-10-20
Ion Channels And Disease written by Frances M. Ashcroft and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-20 with Science categories.
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Ion Channels In Health And Sickness
DOWNLOAD
Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Ion Channels And Transporters Of Epithelia In Health And Disease
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer
Release Date : 2015-12-14
Ion Channels And Transporters Of Epithelia In Health And Disease written by Kirk L. Hamilton and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-14 with Medical categories.
This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Ion Transport Across Epithelial Tissues And Disease
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer Nature
Release Date : 2020-12-12
Ion Transport Across Epithelial Tissues And Disease written by Kirk L. Hamilton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-12 with Medical categories.
This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
Textbook Of Ion Channels Basics And Methods
DOWNLOAD
Author : Jie Zheng
language : en
Publisher:
Release Date : 2023
Textbook Of Ion Channels Basics And Methods written by Jie Zheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with MEDICAL categories.
"From the editors of the renowned Handbook of Ion Channels, Textbook of Ion Channels is a student-friendly, advanced textbook that illustrates the fundamental importance of these membrane proteins to human health and disease. It has been split into three separate volumes so that each volume can target different needs. The basic concepts of ion channel research are introduced in the first volume, whilst volume two focuses on the pharmacology of ion channels' superfamilies, and volume three presents powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs"--
Textbook Of Ion Channels Volume I
DOWNLOAD
Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2023-06-09
Textbook Of Ion Channels Volume I written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-09 with Medical categories.
The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume I, Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity, voltage-dependent, ligand-dependent, and mechano-dependent ion channel activation mechanisms, the mechanisms for ion channel desensitization and inactivation, and basic ion channel pharmacology and inhibition. Volume I, Part 2 offers a practical guide of cardinal methods for researching ion channels, including heterologous expression and voltage-clamp and patch-clamp electrophysiology; isolation of native currents using patch clamping; modeling ion channel gating, structures, and its dynamics; crystallography and cryo-electron microscopy; fluorescence and paramagnetic resonance spectroscopy methods; and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; a modern guide to the properties of major ion channel families; and includes coverage of key examples of regulatory, physiological and disease roles for ion channels.
Ion Channels In Health And Sickness
DOWNLOAD
Author : Kaneez Fatima Shad
language : en
Publisher:
Release Date : 2018
Ion Channels In Health And Sickness written by Kaneez Fatima Shad and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Cytology categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.