Ion Transport Across Epithelial Tissues And Disease
DOWNLOAD
Download Ion Transport Across Epithelial Tissues And Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Ion Transport Across Epithelial Tissues And Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Ion Transport Across Epithelial Tissues And Disease
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer Nature
Release Date : 2020-12-12
Ion Transport Across Epithelial Tissues And Disease written by Kirk L. Hamilton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-12 with Medical categories.
This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
Basic Epithelial Ion Transport Principles And Function
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer Nature
Release Date : 2020-11-26
Basic Epithelial Ion Transport Principles And Function written by Kirk L. Hamilton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.
Studies Of Epithelial Transporters And Ion Channels
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer Nature
Release Date : 2021-03-04
Studies Of Epithelial Transporters And Ion Channels written by Kirk L. Hamilton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Medical categories.
This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
Ion Channels And Transporters Of Epithelia In Health And Disease
DOWNLOAD
Author : Kirk L. Hamilton
language : en
Publisher: Springer
Release Date : 2015-12-14
Ion Channels And Transporters Of Epithelia In Health And Disease written by Kirk L. Hamilton and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-14 with Medical categories.
This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Epithelial Transport Physiology
DOWNLOAD
Author : George A. Gerencser
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Epithelial Transport Physiology written by George A. Gerencser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1–6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7–16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.
Ion Transport In Vertebrate Colon
DOWNLOAD
Author : W. Clauss
language : en
Publisher: Springer
Release Date : 2013-12-19
Ion Transport In Vertebrate Colon written by W. Clauss and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-19 with Science categories.
Studies on the colon not only serve medical interest or clinical purposes, but are also a highly interesting subject of comparative physiology, from which we can learn much about the basic principles in physiology. Presented here are examples of research on colonic ion transport of each vertebrate group, including the classical models of epithelia, rat and rabbit, and also on the special and unique features in fish, amphibians, reptiles, birds, and selected mammals such as the guinea pig. Physiology and pathophysiology of ion transport in the human large intestine are as well covered as the use of colonic cell cultures as model systems for crypt cell properties.
Epithelial Transport Of Ions In Health And Disease
DOWNLOAD
Author : Irene Schulz
language : en
Publisher:
Release Date : 2004
Epithelial Transport Of Ions In Health And Disease written by Irene Schulz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Biological transport categories.
Intestinal Water And Electrolyte Transport In Health And Disease
DOWNLOAD
Author : Mrinalin Rao
language : en
Publisher: Biota Publishing
Release Date : 2012-01-12
Intestinal Water And Electrolyte Transport In Health And Disease written by Mrinalin Rao and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-12 with Medical categories.
The unique architecture and physiology of the mammalian intestine, together with a tightly coordinated regulatory system, allows for the handling and absorption of as much as 9 L of fluid a day with 98% or greater efficiency. Advances in the past 40 years have made inroads into revealing the intricacies and interplay of numerous ion transporters and their modulators that are responsible for intestinal electrolyte and water transport. Studies of two devastating diseases, the virulent infectious disease cholera and the autosomal recessive disease cystic fibrosis, were largely responsible for this information explosion. These advances have been critical in the development of new therapeutic strategies to combat life-threatening diseases of varying etiologies ranging from enteric infections to cystic fibrosis and inflammatory bowel diseases. Yet, the story is far from complete, and progress needs to continue on translating information gained from reductionistic cell and tissue culture models, in vivo models, and ultimately human studies and on improving therapeutic approaches. This book reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease. Table of Contents: Overview / Epithelial Cell and Tissue Architecture / Principles of Transepithelial Electrolyte and Water Movement / Intestinal Architecture and Electrolyte Transport / Electrolyte Transporters--Pumps, Carriers, and Channels / Water Transport / Regulation / Intestinal Disorders and Advances Toward Better Treatment of Intestinal Disorders / Conclusion / References
Assessment Of Airway Epithelial Ion Transport Functions In Patients In Excised Tissues And In Cultured Cells
DOWNLOAD
Author : M. J. Stutts
language : en
Publisher:
Release Date : 1985
Assessment Of Airway Epithelial Ion Transport Functions In Patients In Excised Tissues And In Cultured Cells written by M. J. Stutts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with categories.
A great deal of information about function of the epithelium that lines the respiratory tract has accrued in recent years. Because this tissue is so exposed and its functions are so important in the defense of the lung against infection, much of this research has centered on the role of pollutant induced damage to epithelial function in environmental lung disease. Such research is difficult to carry out in normal human subjects, so many kinds of in vivo and in vitro research techniques involving animals have been used. In the interpretation of such experiments the question is always raised as to what if any meaning can be drawn for potential human exposure. To answer this question this study will determine if the end point against which an agent's toxicity is being assessed, in vitro, represents a similar function, in vivo. The purpose of the function chosen to measure will be determined so that any findings can be logically extrapolated to human health. Results which demonstrate how disease related differences in function detected in vivo have been elucidated by in vitro experiments and how these differences are manifest in cell culture are presented. Some animal data selected to illustrate the real difficulties of interpretation that can be encountered are given.
Intestinal Transport
DOWNLOAD
Author : M. Gilles-Baillien
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Intestinal Transport written by M. Gilles-Baillien and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The aim of this symposium was to provide a framework for fruitful discussion on intestinal transport, not only for advanced scientists but also for younger people starting in this field of research. Invited lectures, communications and poster presentations were focused on four central themes, all treating the prop erties of the sole intestinal epithelium, deliberately leaving aside problems dealing with more integrative functions of the whole intestine. The importance of motility or blood circulation, for instance, is certainly capital in the overall intestinal function, but these aspects by themselves deserve another meeting. This volume has compiled the manuscripts of the invited lectures which sub stantially comprised the four sessions of the Symposium. Part 1 is designed to emphasize actual knowledge of the transport of water, inorganic as well as organic ions and molecules across the isolated intestinal epithelium. An enormous wave of investigations has emerged from studies per formed with "Ussing chambers", which roused interest in studies on absorption mechanisms and subsequently on secretory processes. This has triggered off a trend to research on isolated cells as absorption and secretion are the main func tion of the different cell types constituting the intestinal epithelium. In this first session not only the importance of the parallel arrangement of these different cellular entities is stressed, but also the role played by the paracellular route.
