Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition
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Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition
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Author : Chengjin Gao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06
Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition written by Chengjin Gao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Science categories.
The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and ?d T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases. The goal of this Research Topic is to provide a forum to advance research on the contribution of the fundamental mechanisms of immune system development and function, with special emphasis on the description and mechanism of clinical immunological phenotypes in different immune disorders and the definition of their molecular basis. The Research Topic had the bullet points including but not limited to the following: 1) Description of the immune phenotypes of various common acute and chronic diseases; 2) The regulatory mechanisms of different factors on the development and function of the host immune system; 3) Inflammatory immunological mechanisms, organ function, and interorgan interactions.
Carranza S Clinical Periodontology E Book
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Author : Chini Doraiswami Dwarakanath
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-08-19
Carranza S Clinical Periodontology E Book written by Chini Doraiswami Dwarakanath and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-19 with Medical categories.
The book comes with complimentary access to enhanced e-book with additional reads on: - The Historical Background of Periodontology - Molecular Biology of Host-Microbe Interactions - Gingival Disease in Childhood - Desquamative Gingivitis - Necrotizing Ulcerative Periodontitis - Masticatory System Disorders that Influence the Periodontium - Sleep-Disordered Breathing - Significance of Clinical and Biologic Information - Conscious Sedation - Periodontal Therapy in the Female Patient - Periodontal Treatment for Older Adults - Occlusal Evaluation and Therapy - Multidisciplinary Approach to Dental and Periodontal Problems - Results of Periodontal Treatment - Atlas of Periodontal Diseases - Electronic Dental Records and Decision Support Systems - Locally Delivered, Controlled-Release Antimicrobials: Drug Development and Clinical Research
Unraveling The Molecular Mechanisms Of Cytokine Signaling In Regulating Inflammatory Diseases
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Author : Wai Po Chong
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-09
Unraveling The Molecular Mechanisms Of Cytokine Signaling In Regulating Inflammatory Diseases written by Wai Po Chong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-09 with Medical categories.
Chronic and dysregulated inflammation play a significant role in the pathogenesis of autoimmune diseases and inflammatory diseases. Despite the prevalence and impact of these diseases, the molecular mechanisms underlying cytokine regulation in these inflammatory diseases remain poorly understood. This special issue aims to address this knowledge gap by discovering the intricate network of cytokine signaling pathways in immunoregulation during inflammatory diseases. By unraveling these molecular mechanisms, we can gain valuable insights into the dysregulation of cytokines in immune responses. This deeper understanding will enable us to identify specific molecules, signaling pathways, and cellular interactions that contribute to disease progression. Such knowledge is crucial for the development of targeted therapeutic interventions that can restore immune balance and mitigate the detrimental effects of inflammation. Moreover, the elucidation of these molecular mechanisms may also provide opportunities for the discovery of novel therapeutic targets. By understanding the key molecules or pathways that drive the dysregulation of cytokine signaling pathways, researchers can develop innovative approaches to modulate or manipulate these targets, ultimately leading to the development of more effective treatments for autoimmune and inflammatory diseases.
Pharmacological Approaches Targeting Neutrophilic Inflammation Volume Ii
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Author : Galina Sud’ina
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-22
Pharmacological Approaches Targeting Neutrophilic Inflammation Volume Ii written by Galina Sud’ina and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-22 with Science categories.
Encyclopedia Of Molecular Mechanisms Of Disease
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Author : Florian Lang
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-19
Encyclopedia Of Molecular Mechanisms Of Disease written by Florian Lang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-19 with Science categories.
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
Rheumatology E Book
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Author : Marc C. Hochberg
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-07-29
Rheumatology E Book written by Marc C. Hochberg and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-29 with Medical categories.
Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via [email protected].
Acute Leukemias Molecular Characterization Leukemiainitiating Cells And Influence Of The Microenvironment
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Author : Spiros Vlahopoulos
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-06
Acute Leukemias Molecular Characterization Leukemiainitiating Cells And Influence Of The Microenvironment written by Spiros Vlahopoulos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-06 with Medical categories.
Neuroscience For Clinicians
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Author : Eduardo E. Benarroch MD
language : en
Publisher: Oxford University Press
Release Date : 2021-06-10
Neuroscience For Clinicians written by Eduardo E. Benarroch MD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-10 with Medical categories.
Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets . This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.
Dubois Lupus Erythematosus And Related Syndromes E Book
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Author : Daniel Wallace
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-09-27
Dubois Lupus Erythematosus And Related Syndromes E Book written by Daniel Wallace and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-27 with Medical categories.
Recognized for more than 45 years as the definitive text in the field, Dubois’ Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE. Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons. Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells. Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field. Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at www.expertconsult.com. Dubois’ Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases. For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes.
Textbook Of Pediatric Rheumatology
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Author : Ross E. Petty
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-04-14
Textbook Of Pediatric Rheumatology written by Ross E. Petty and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-14 with Medical categories.
Matchless in reputation, content, and usefulness, Textbook of Pediatric Rheumatology, 7th Edition, is a must-have for any physician caring for children with rheumatic diseases. It provides an up-to-date, global perspective on every aspect of pediatric rheumatology, reflecting the changes in diagnosis, monitoring, and management that recent advances have made possible – all enhanced by a full-color design that facilitates a thorough understanding of the science that underlies rheumatic disease. Get an authoritative, balanced view of the field with a comprehensive and coherent review of both basic science and clinical practice. Apply the knowledge and experience of a who’s who of international experts in the field. Examine the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, including the presentation, differential diagnosis, course, management, and prognosis of every major condition. Diagnose and treat effectively through exhaustive reviews of the complex symptoms and signs and lab abnormalities that characterize these clinical disorders. Keep current with the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Increase your knowledge with three all-new chapters on laboratory investigations, CNS vasculitis, and other vasculitides. Understand the evolving globalization of pediatric rheumatology, especially as it is reflected in the diagnosis and management of childhood rheumatic diseases in the southern hemisphere. Choose treatment protocols based on the best scientific evidence available today.