Chemical Epigenetics
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Chemical Epigenetics
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Author : Antonello Mai
language : en
Publisher: Springer Nature
Release Date : 2020-03-31
Chemical Epigenetics written by Antonello Mai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-31 with Science categories.
This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.
Enzymes Of Epigenetics
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Author :
language : en
Publisher: Elsevier
Release Date : 2016-07-14
Enzymes Of Epigenetics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-14 with Science categories.
Enzymes of Epigenetics: Part B, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed in the study of epigenetic regulation, including structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies, and small molecule epigenetic regulators and biological connections. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Contains two new volumes that cover research methods in enzymes of epigenetics Covers such topics as chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections
Toxicology And Epigenetics
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Author : Saura C. Sahu
language : en
Publisher: John Wiley & Sons
Release Date : 2012-08-23
Toxicology And Epigenetics written by Saura C. Sahu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-23 with Science categories.
Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.
Epigenetic Drug Discovery
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Author : Wolfgang Sippl
language : en
Publisher: John Wiley & Sons
Release Date : 2019-03-25
Epigenetic Drug Discovery written by Wolfgang Sippl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-25 with Medical categories.
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.
Epigenetics Development And Disease
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Author : Tapas Kumar Kundu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-13
Epigenetics Development And Disease written by Tapas Kumar Kundu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Medical categories.
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Epigenetics For Drug Discovery
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Author : Nessa Carey
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-20
Epigenetics For Drug Discovery written by Nessa Carey and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-20 with Medical categories.
This book will provide an invaluable guide to epigenetics, one of the fastest moving fields in drug discovery, for medicinal chemists working in academia and in the pharmaceutical industry.
Chemical Biology Of The Genome
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Author : Siddhartha Roy
language : en
Publisher: Academic Press
Release Date : 2021-05-14
Chemical Biology Of The Genome written by Siddhartha Roy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-14 with Science categories.
Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery
Epigenetics Book
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Author : Roy Carroll
language : en
Publisher: Youcanprint
Release Date : 2022-01-25
Epigenetics Book written by Roy Carroll and has been published by Youcanprint this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-25 with Medical categories.
You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!
Enzymes Of Epigenetics
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-07-13
Enzymes Of Epigenetics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-13 with Science categories.
Enzymes of Epigenetics, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed to study epigenetic regulation and includes structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections
Examining The Causal Relationship Between Genes Epigenetics And Human Health
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Author : Wambuguh, Oscar J.
language : en
Publisher: IGI Global
Release Date : 2019-03-22
Examining The Causal Relationship Between Genes Epigenetics And Human Health written by Wambuguh, Oscar J. and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-22 with Medical categories.
For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.