Epigenetics Development And Disease
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Epigenetics Development And Disease
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Author : Tapas Kumar Kundu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-13
Epigenetics Development And Disease written by Tapas Kumar Kundu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Medical categories.
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Epigenetic Mechanisms In Development And Disease
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Author : Paul J. Hurd
language : en
Publisher:
Release Date : 2013
Epigenetic Mechanisms In Development And Disease written by Paul J. Hurd and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Cell differentiation categories.
Epigenetic Mechanisms in Development and Disease, the latest volume in the Biochemical Society Symposia series, features ten chapters from the Biochemical Society's Annual Symposium held at the University of Leeds on 11 - 13 December 2012. Epigenetic mechanisms, including the post translational modifications of chromatin (DNA and histones), play pivotal roles in development, cell differentiation and cell identity. Inappropriate regulation of epigenetic mechanisms has been implicated in common human diseases including diabetes, neuropsychiatric disorders and cancers. Environmental influences such as nutrition and stress can lead to epigenetic alterations and contribute to chronic disease biology.
The Epigenome And Developmental Origins Of Health And Disease
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Author : Cheryl S Rosenfeld
language : en
Publisher: Academic Press
Release Date : 2015-10-10
The Epigenome And Developmental Origins Of Health And Disease written by Cheryl S Rosenfeld and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-10 with Science categories.
The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field
Epigenetics In Health And Disease
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Author : Igor Kovalchuk
language : en
Publisher: FT Press
Release Date : 2012-05-22
Epigenetics In Health And Disease written by Igor Kovalchuk and has been published by FT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-22 with Education categories.
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.
Computational Epigenetics And Diseases
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-02-06
Computational Epigenetics And Diseases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with Business & Economics categories.
Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases
Epigenetic Aspects Of Chronic Diseases
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Author : Helmtrud I. Roach
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-01
Epigenetic Aspects Of Chronic Diseases written by Helmtrud I. Roach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-01 with Medical categories.
Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.
Epigenetics In Human Reproduction And Development
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Author : Naumova Anna K
language : en
Publisher: World Scientific
Release Date : 2016-12-20
Epigenetics In Human Reproduction And Development written by Naumova Anna K and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-20 with Medical categories.
Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood. Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.
Environmental Epigenomics In Health And Disease
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Author : Randy L Jirtle
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-16
Environmental Epigenomics In Health And Disease written by Randy L Jirtle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-16 with Medical categories.
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.
Epigenetics In Human Disease
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Author : Trygve O. Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2012-07-26
Epigenetics In Human Disease written by Trygve O. Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-26 with Medical categories.
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
Human Epigenetics How Science Works
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Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2019-09-24
Human Epigenetics How Science Works written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-24 with Medical categories.
The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.