Chemical Synthesis Of Nucleoside Analogues
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Chemical Synthesis Of Nucleoside Analogues
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Author : Pedro Merino
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-12
Chemical Synthesis Of Nucleoside Analogues written by Pedro Merino and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-12 with Science categories.
Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Enzymatic And Chemical Synthesis Of Nucleic Acid Derivatives
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Author : Jesús Fernández Lucas
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-29
Enzymatic And Chemical Synthesis Of Nucleic Acid Derivatives written by Jesús Fernández Lucas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Science categories.
A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.
Chemistry And Biology Of Nucleosides And Nucleotides
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Author : Robert Harmon
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Chemistry And Biology Of Nucleosides And Nucleotides written by Robert Harmon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.
The Enzymatic And Chemical Synthesis Of Nucleoside Analogues Using N Deoxyribosyltransferase From Lactobacillus Leichmannii
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Author : Nicola Hicks
language : en
Publisher:
Release Date : 1992
The Enzymatic And Chemical Synthesis Of Nucleoside Analogues Using N Deoxyribosyltransferase From Lactobacillus Leichmannii written by Nicola Hicks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Nucleoside Analogues
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Author : R. T. Walker
language : en
Publisher: Springer
Release Date : 1979-12
Nucleoside Analogues written by R. T. Walker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979-12 with Medical categories.
This publication contains the Review Lectures given at a joint NATO Advanced Study Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the 7th - 18th May 1979. The Course entitled "Nucleoside Analogues : Chemistry, Biology and Medical Applications" was held for several reasons. In the past few years, many useful and potentially-useful nucleoside analogues have either reached the stage of clinical use or are undergoing clinical trials. Many more compounds have been synthesised by the organic chemist and little more has been done with them other than possibly a few perfunctory biological tests. This is often due to either a lack of interest or an inadequate knowledge of the testing proced ures available or a lack of communication between the chemist, biochemist, pharmacologist and the clinician such that few compounds receive the testing and evaluation which they deserve. The aim of this meeting was to gather together many of the experts in the different scientific disciplines which are involved in the design, synthesis, testing and clinical use of nucleoside analogues, primarily as anti-viral and anti-cancer agents, and to discuss in depth the fundamental principles of each discipline so that participants could understand each other's problems and be more aware of the information required and that which can be obtained.
Nucleoside Triphosphates And Their Analogs
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Author : Morteza Vaghefi
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Nucleoside Triphosphates And Their Analogs written by Morteza Vaghefi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
While adenosine triphosphate (ATP) is described as the universal currency of energy in all living organisms at the cellular level, the actual power lies in its phosphate tail. This book is the first dedicated to the field of nucleoside triphosphate (NTP). Its 13 chapters encompass the contributions of twenty scientists from both academia and industry. It provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP and their application in life sciences. Three chapters review families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. The appendix includes supporting NMR data.
Synthesis Of A Heptasaccharide And Some 3 C Branched Nucleoside Analogues
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Author : Lars Svansson
language : en
Publisher:
Release Date : 1992
Synthesis Of A Heptasaccharide And Some 3 C Branched Nucleoside Analogues written by Lars Svansson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Glycosides categories.
Synthesis Of Nucleoside Analogues With Potential Antiviral Activity Against Negative Strand Rna Virus Targets
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Author : H. C. Meacham
language : en
Publisher:
Release Date : 1987
Synthesis Of Nucleoside Analogues With Potential Antiviral Activity Against Negative Strand Rna Virus Targets written by H. C. Meacham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.
The purpose of this work is to synthesis nucleoside analogues which are targeted against the replicase of negative-strand viruses. Two lines of investigation have been started: (i) the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and (ii) the synthesis of potential ribonucleoside 5' -triphosphate analogues. A series of compounds of type (i) have been synthesised and submitted for biological evaluation. One compound of type (ii) has been made and further work is in progress. Keywords: Antiviral agents; Chemical analogs; Synthesis(Chemistry); Chemotherapy.
Acyclic Carbocyclic And L Nucleosides
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Author : L. Agrofoglio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-08
Acyclic Carbocyclic And L Nucleosides written by L. Agrofoglio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-08 with Science categories.
Interest in chemical entities capable of blocking or modifying cell metabolism ultimately goes back to the discovery of the structure of DNA in the 1950s. Understanding of the biochemical processes involved in cell metabolism rapidly led to the idea that compounds could be designed which might interfere with these processes, and thus could be used in the treatment of the diseases caused by viral infection. Since then, several classes of drugs have been discovered which depend for their effect on modification of the proper functioning of nucleic acids and, with the introduction of acyclovir for the treatment of Herpes infections, nucleoside analogues have become the cornerstone of antiviral chemotherapy. The success of the early nucleoside agents, the toxicity and metabolic instability of many nucleoside analogues, and the effects of viral pathogens on public health are driving the design, synthesis and evaluation of new nucleoside analogues, with much attention turning to nucleosides containing `non natural' sugar analogues. This book focuses on the development of these agents, and draws together all the available material in an easily consulted form, which at the same time guides the reader into the research literature on the subject. Written primarily for the medicinal chemist, coverage includes both synthetic strategies and outline guidance on the main trends in biological activity. Particular attention is drawn to the comparison of synthetic routes to compounds with their natural analogues. Finally, the important antiviral activities of the compounds are treated, including anti-retrovirus, anti-hepadnavirus and anti-herpes virus properties. Written mainly for medicinal chemists in the pharmaceutical industry and synthetic organic chemists in academe, this book will also be attractive to researchers in institutions focusing on cellular metabolism. Advanced students of organic chemistry will find the clear discussion of the synthetic strategies adopted in the development of these compounds a useful introduction to this exciting and challenging area.
Nucleosides As Biological Probes
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Author : Robert J. Suhadolnik
language : en
Publisher: John Wiley & Sons
Release Date : 1979-09-10
Nucleosides As Biological Probes written by Robert J. Suhadolnik and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979-09-10 with Medical categories.
Examines the application of about 70 naturally occurring nucleoside and nucleotide analogs as biochemical probes in cellular reactions of humans, animals, mammalian cells in tissue culture, bacteria, fungi, viruses, and plants. Describes the discovery, isolation, production, physical and chemical properties, structural elucidation, syntheses, inhibitory properties, and biosynthesis of each newly discovered nucleoside analog. Includes a description of those nucleoside analogs currently accepted for treatment of cancer and viral infections in humans. Contains 1100 references.