Chemogenomics In Drug Discovery
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Chemogenomics In Drug Discovery
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Author : Hugo Kubinyi
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Chemogenomics In Drug Discovery written by Hugo Kubinyi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
Chemogenomics
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Author : Edgar Jacoby
language : en
Publisher: World Scientific
Release Date : 2006-05-11
Chemogenomics written by Edgar Jacoby and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-11 with Medical categories.
In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays. This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided. Contents: Small Molecules for Chemogenomics-based Drug Discovery (E Jacoby et al.)Mapping the Chemogenomic Space (J Mestres)Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development (F J Dekker et al.)A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries (R Crossley & M Slater)In silico Screening of the Protein Structure Repertoire and of Protein Families (D Rognan)New Methods for Smilarity-based Virtual Screening (J Hert et al.)Structural Informatics: Chemogenomics In silico (D A Debe et al.)Construction of a Homogenous and Informative In vitro Profiling Database for Anticipating the Clinical Effects of Drugs (N Froloff et al.)The Inpharmatica Pharmacata Approach (J Overinghton)Target- and Cell-Based Assays and Screening: Reverse Chemogenomics (R Bouhelal & D Frabbro) Readership: Undergraduate and graduate students, and researchers in molecular pharmacology, pharmacy, medicinal chemistry, molecular and structural biology, drug discovery, genomics, bioinformatics. Key Features:Provides a unique overview of state-of-the-art chemogenomics knowledge-based approaches for target and drug identificationWritten by leading scientists in the various disciplines involved in chemogenomicsKeywords:Chemogenomics;Drug Discovery;Medicinal Chemistry;Knowledge-Based Approaches;Design of Compound Screening Collections;Natural Products;Target Families;Chemoinformatics;Bioinformatics;Mode of Action Profiling
Chemogenomics
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Author : Edgar Jacoby
language : en
Publisher: Methods in Molecular Biology
Release Date : 2009-09-17
Chemogenomics written by Edgar Jacoby and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-17 with Medical categories.
The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular BiologyTM series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.
Computational Chemogenomics
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Author : Edgar Jacoby
language : en
Publisher: CRC Press
Release Date : 2013-12-03
Computational Chemogenomics written by Edgar Jacoby and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-03 with Medical categories.
This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analys
Genomics In Drug Discovery And Development
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Author : Dimitri Semizarov
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-03
Genomics In Drug Discovery And Development written by Dimitri Semizarov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-03 with Medical categories.
Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.
Pharmacogenomics In Drug Discovery And Development
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Author : Qing Yan
language : en
Publisher: Springer Nature
Release Date : 2022-09-06
Pharmacogenomics In Drug Discovery And Development written by Qing Yan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-06 with Medical categories.
This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.
Chemical Genomics
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Author : Stefan Jaroch
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-26
Chemical Genomics written by Stefan Jaroch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-26 with Science categories.
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Enabling Precision Medicine
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-11-17
Enabling Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-17 with Medical categories.
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.
Chemical Genomics
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Author : Dr. Anil Sehgal
language : en
Publisher: D&MD Publications
Release Date : 2004-01-01
Chemical Genomics written by Dr. Anil Sehgal and has been published by D&MD Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-01 with Chemogenomics categories.
Chemical Genomics
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Author : Stefan Jaroch
language : en
Publisher: Springer
Release Date : 2009-09-02
Chemical Genomics written by Stefan Jaroch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Science categories.
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.