Chemotherapy Of Viral Infections
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Chemotherapy Of Viral Infections
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Author : P E. Came
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemotherapy Of Viral Infections written by P E. Came and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.
Chemotherapy Of Viral Infections
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Author : P E. Came
language : en
Publisher: Springer
Release Date : 2012-01-16
Chemotherapy Of Viral Infections written by P E. Came and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-16 with Medical categories.
" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.
Antiviral Chemotherapy 5
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Author : John Mills
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antiviral Chemotherapy 5 written by John Mills and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since. Two new classes of antiretrovirals have been licensed, the second-site RT inhibitors and the protease inhibitors; the long in cubation period of active HIV infection, when the infection is clinically latent, is now un derstood to be a period of intense viral replication and turnover of CD4 lymphocytes; measurements of HI V RNA concentration in plasma have been shown to be essential tools for monitoring the course of HIV infection, deciding when to treat, and assessing the re sults of treatment; and finally, combinations of antiretrovirals, particularly combinations including protease inhibitors, have been shown to have dramatically beneficial effects on patients with HIV infection. These advances, coupled with new drugs for the management of herpesvirus infections, have made dramatic differences in the quality and length of life of HIV-infected patients. Additional advances have been made since 1994 in the prevention or management of influenza virus (zanamavir), respiratory syncytial virus (palvizumab), hepatitis B virus (lamivudine and famciclovir), and enterovirus infections (pleconaril). It is difficult to re member that only slightly more than a decade ago there were only a handful of antiviral agents available (none of which were antiretrovirals), and a number of those were either highly toxic, of dubious efficacy, or both.
Antiviral Chemotherapy 4
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Author : John Mills
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Antiviral Chemotherapy 4 written by John Mills and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.
Chemotherapy Of Viral Infections
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Author : P E. Came
language : en
Publisher: Springer
Release Date : 1982-08-01
Chemotherapy Of Viral Infections written by P E. Came and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-08-01 with Medical categories.
" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.
Viral Chemotherapy
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Author : David Shugar
language : en
Publisher: Pergamon
Release Date : 1984
Viral Chemotherapy written by David Shugar and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.
Antiviral Chemotherapy
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Author : Hans W. Doerr
language : en
Publisher:
Release Date : 1998
Antiviral Chemotherapy written by Hans W. Doerr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Antiviral agents categories.
Antiviral chemotherapy is still far away from the high success rate of antibacterial therapy, but the situation is improving. In recent years, several new substances have been found to be active against a variety of viral infections. This special issue presents the current possibilities and the most promising new approaches for treatment of AIDS, hepatitis B and C, papillomas and infections by members of the Herpesviridae family. Most antiviral drugs continue to be nucleoside or nucleotide analogs. Lamivudine, e.g., originally developed against HIV, and famciclovir, developed against herpesviruses, have both turned out to be very effective against hepatitis B virus. Several new substances which have proven active against HIV, cytomegalovirus, varizella/zoster virus or herpes simplex virus, are described in detail. No adequate therapy currently exists against hepatitis C, but the expression of some potential target molecules of the virus opens up ways to search for specific inhibitors. Further topics considered are the use of immunostimulatory drugs, and the role of viral and cellular resistance mechanisms in long-term antiviral therapy. Providing the latest data on the usefulness and limitations of licensed and experimental drugs, this issue will be of interest to all medical virologists and infectious disease specialists as well as to hepatologists and transplantation specialists.
Antiviral Chemotherapy
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Author : Richard Challand
language : en
Publisher:
Release Date : 1997
Antiviral Chemotherapy written by Richard Challand and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
A textbook for an upper-level or graduate course for students with a background in chemistry or biochemistry. Traces the history of antivirals and presents the current understanding of viral biochemistry, the mechanisms of small molecules and their development as drugs, and the application of various types of chemical therapies. Includes a glossary without pronunciation. Annotation copyrighted by Book News, Inc., Portland, OR
Antiviral Drugs
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Author : Karl Lonberg-Holm
language : en
Publisher:
Release Date : 1974
Antiviral Drugs written by Karl Lonberg-Holm and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Antiviral agents categories.
Antiviral Chemotherapy Interferons And Vaccines
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Author : David O. White
language : en
Publisher:
Release Date : 1984
Antiviral Chemotherapy Interferons And Vaccines written by David O. White and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Antiviral agents categories.