Chirality From Dynamic Kinetic Resolution
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Chirality From Dynamic Kinetic Resolution
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Author : Helene Pellissier
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011-04-04
Chirality From Dynamic Kinetic Resolution written by Helene Pellissier and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-04 with Science categories.
The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
Dynamic Stereochemistry Of Chiral Compounds
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Author : Christian Wolf
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Dynamic Stereochemistry Of Chiral Compounds written by Christian Wolf and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Education categories.
A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.
Chirality From Dynamic Kinetic Resolution
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Author : Hélène Pellissier
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011
Chirality From Dynamic Kinetic Resolution written by Hélène Pellissier and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
Organocatalytic Dynamic Kinetic Resolution
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Author : Hélène Pellissier
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-05-06
Organocatalytic Dynamic Kinetic Resolution written by Hélène Pellissier and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-06 with Science categories.
In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.
Dynamic Kinetic Resolution Dkr And Dynamic Kinetic Asymmetric Transformations Dykat
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Author : Jan-E. Bäckvall
language : en
Publisher: Georg Thieme Verlag
Release Date : 2022-12-07
Dynamic Kinetic Resolution Dkr And Dynamic Kinetic Asymmetric Transformations Dykat written by Jan-E. Bäckvall and has been published by Georg Thieme Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Science categories.
Principles and applications of DKR and DYKAT DKR and DYKAT are of ever increasing importance in the synthesis of enantiomerically enriched compounds. The preparation of enantiomerically pure compounds is of great importance in society today, in particular in pharmaceutical chemistry and in the agrochemical sector. Kinetic resolution is a popular method for differentiating two enantiomers in a racemic mixture that react at different rates with a chiral catalyst or reagent. The drawback of kinetic resolution is that the yield of one pure enantiomer is limited to a maximum of 50%. To overcome this limitation, an in situ racemization of the starting material can be combined with a kinetic resolution. This combination leads to a so called “dynamic kinetic resolution” (DKR), where the two enantiomers are in equilibrium with one another. The slow-reacting enantiomer will continuously be converted into the fast-reacting one, when the latter is transformed into the enantiomerically pure product. Thus, a racemic starting material can be transformed in catalytic processes into a single isomer of a chiral compound in up to 100% yield. DKR only applies to the resolution of racemic mixtures and the involvement of enantiomers leads to simple kinetics. When diastereomers, either as starting materials or as diastereomeric intermediates, are involved in the resolution process under dynamic conditions (via equilibria between diastereomers), the kinetics is different from DKR. These reactions are classified as “dynamic kinetic asymmetric transformations” (DYKAT). This volume covers the principles of DKR and DYKAT and presents examples of organocatalytic, chemoenzymatic, and transition-metal catalyzed approaches, including applications in the synthesis of complex, biologically active compounds.
Chiral Drugs
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Author : Guo-Qiang Lin
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-08
Chiral Drugs written by Guo-Qiang Lin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-08 with Science categories.
An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.
Stereochemistry And Stereoselective Synthesis
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Author : Mihály Nógrádi
language : en
Publisher: John Wiley & Sons
Release Date : 2016-06-22
Stereochemistry And Stereoselective Synthesis written by Mihály Nógrádi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-22 with Science categories.
Written by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.
Discrimination Of Mobile Supramolecular Chirality
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Author : Ayumi Imayoshi
language : en
Publisher: Springer Nature
Release Date : 2021-11-18
Discrimination Of Mobile Supramolecular Chirality written by Ayumi Imayoshi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-18 with Science categories.
This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
Catalytic Asymmetric Synthesis
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Author : Iwao Ojima
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-14
Catalytic Asymmetric Synthesis written by Iwao Ojima and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
Praise for the previous editions "An excellent text . . . will no doubt provide the benchmark for comparative works for many years." —Journal of the American Chemical Society "An excellent state-of-the-art compilation of catalytic asymmetric chemistry . . . should be included in any chemistry reference collection." —Choice "This is a tremendous resource and an excellent read. I recommend immediate purchase." —Perkin Transactions Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields—from medicine to materials science. Catalytic Asymmetric Synthesis, Third Edition addresses these rapid changes through contributions from highly recognized world leaders in the field. This seminal text presents detailed accounts of the most important catalytic asymmetric reactions known today, and discusses recent advances and essential information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Third Edition features: Six entirely new chapters focusing on novel approaches to catalytic asymmetric synthesis including non-conventional media/conditions, organocatalysis, chiral Lewis and Bronsted acids, CH activation, carbon-heteroatom bond-forming reactions, and enzyme-catalyzed asymmetric synthesis A new section focusing on the important new reaction, asymmetric metathesis, in carbon-carbon bond-forming reactions Updated chapters on hydrogenation, carbon-carbon bond-forming reactions, hydrosilylations, carbonylations, oxidations, amplifications and autocatalysis, and polymerization reactions Retaining the best of its predecessors but now thoroughly up to date, Catalytic Asymmetric Synthesis, Third Edition serves as an excellent desktop reference and text for researchers and students from the upper-level undergraduates through experienced professionals in industry or academia.
Non Metal Catalyzed Synthesis
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Author : Yunfei Du
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2023-12-04
Non Metal Catalyzed Synthesis written by Yunfei Du and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-04 with Science categories.
Non-metal catalysis may provide new and green methods for obtaining bioactive heterocycles. Many catalysts contain metals, which can be toxic, energy intensive to remove, and require mining of the source materials. By utilizing metal-free catalysts we avoid these issues. This book explores the use of non-metal catalysts when synthesizing various heterocyclic structures with bioactivity.