Cholesterol Modulation Of Protein Function
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Cholesterol Modulation Of Protein Function
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Author : Avia Rosenhouse-Dantsker
language : en
Publisher: Springer
Release Date : 2019-01-16
Cholesterol Modulation Of Protein Function written by Avia Rosenhouse-Dantsker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-16 with Science categories.
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Direct Mechanisms In Cholesterol Modulation Of Protein Function
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Author : Avia Rosenhouse-Dantsker
language : en
Publisher: Springer
Release Date : 2019-05-16
Direct Mechanisms In Cholesterol Modulation Of Protein Function written by Avia Rosenhouse-Dantsker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-16 with Science categories.
In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Cholesterol And Pi 4 5 P2 In Vital Biological Functions
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Author : Avia Rosenhouse- Dantsker
language : en
Publisher: Springer Nature
Release Date : 2023-03-29
Cholesterol And Pi 4 5 P2 In Vital Biological Functions written by Avia Rosenhouse- Dantsker and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-29 with Science categories.
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other’s levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others. Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI(4,5) P2 Provides an overview of the emerging relationship between cholesterol and PI(4,5)P2 in biological systems and processes Discusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk
Structural And Dynamic Aspects Of Protein Function And Allostery
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Author : George Lisi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-28
Structural And Dynamic Aspects Of Protein Function And Allostery written by George Lisi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.
Bioactive Lipids And Lipidomics 2018
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Author : Mario Ollero
language : en
Publisher: MDPI
Release Date : 2020-12-15
Bioactive Lipids And Lipidomics 2018 written by Mario Ollero and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-15 with Science categories.
After the coming of age of lipidomics, the science of global lipid analysis has broadened its contribution to the understanding of biological processes. This volume represents a transversal view on the state of the art of research on lipid biology and bioactive lipid molecules. It includes research and review articles on the role of bioactive lipids in diverse domains like cell signaling, neuromuscular transmission, cancer pathophysiology, cardiovascular and rare diseases, antibacterial activity, the emergency of biomaterials, and associated technological and analytical developments. It provides an instantaneous picture of the place of lipidomics and its fields of application, as well as hints about the directions that lipid research may follow in the near future.
The Perplexing Physiology Of The Nociceptive System
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Author : Istvan Nagy
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-11
The Perplexing Physiology Of The Nociceptive System written by Istvan Nagy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-11 with Science categories.
Impacts that threaten or indeed compromise the integrity of tissues trigger the development of a defence response, which through the activity of the nociceptive system includes pain. If the noxious impact does not induce tissue damage, the pain, called “nociceptive” pain, ceases within seconds after the impact is withdrawn. In contrast, if tissue damage does occur, a pain experience that usually persists until the injury is resolved and includes two major pathological sensory experiences, hypersensitivity to heat stimuli (i.e. heat hyperalgesia) and/or hypersensitivity to mechanical stimuli (i.e. mechanical allodynia) develop. The cellular and molecular mechanisms underlying the development of nociceptive pain are fairly well understood. Our understanding of the development of pain associated with tissue injury has also significantly improved in the last decades. Hence, two fundamental mechanisms, interactions between the nervous and immune systems both within and without the central nervous system and sensitization that is a use-dependent increase in the sensitivity and activity of neurons involved in nociceptive processing have been identified being pivotal for the development of tissue injury-associated pain. However, important details of the cellular and molecular mechanisms, which account for the development of the pathological sensory experiences and those experiences becoming persistent, still await elucidation.
The Membranes Of Cells
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Author : Philip L. Yeagle
language : en
Publisher: Academic Press
Release Date : 2016-02-17
The Membranes Of Cells written by Philip L. Yeagle and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-17 with Science categories.
The Membranes of Cells, Third Edition, provides a basic guide to biomembranes, connecting researchers to the numerous fields of biology. The new edition offers a complete update of content based on new understandings in the field. Foundational content for graduate students, researchers, professors, and undergraduate students across the sciences is provided, succinctly covering all of the basic information needed for lipids and membranes. - Connects membrane research to numerous fields of biology - Provides a basic guide to the interdisciplinary studies of membranes - Offers a companion website with recommended readings and dynamic visual representations of the content - Includes four color illustrations to offer the best visual representation of concepts
The Structure Of Biological Membranes Third Edition
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Author : Philip L. Yeagle
language : en
Publisher: CRC Press
Release Date : 2011-07-18
The Structure Of Biological Membranes Third Edition written by Philip L. Yeagle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-18 with Medical categories.
Biological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition provides readers with an understanding of membrane structure and function that is rooted in the history of the field and brought to the forefront of current knowledge. The first part of the book focuses on the fundamentals of lipid bilayers and membrane proteins. Three introductory chapters supply those new to the field with the tools and conceptual framework with which to approach the state-of-the-art chapters that follow. The second part of the book presents in-depth analyses of focused subjects within the study of membranes, covering topics that include: Phase behavior of lipid bilayers Lipid bilayers as an isolated structure Cholesterol’s role in cell biology Lateral organization of membranes The role of membrane lipids in initial membrane protein folding Membrane protein synthesis and assembly of oligomeric membrane proteins Membrane protein stability with relationships to function and protein turnover Membrane protein function using a transport protein Interactions between membrane proteins and membrane lipids A final chapter pulls together many of the topics, examining in detail the complexity inherent in the synthesis and assembly of lipids and proteins in mitochondrial membranes. With contributions from leading researchers, this completely revised and updated third edition reflects recent advances in the field of biological membranes. It offers a valuable resource for students, as well as structural biologists, biophysicists, cell biologists, biochemists, and researchers in the pharmaceutical and biotechnology industries. What’s New in This Edition: Three accessible chapters introduce students to the field of biological membranes Completely revised and updated chapters present current topics in membrane research
The Structure Of Biological Membranes
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Author : Philip L. Yeagle
language : en
Publisher: CRC Press
Release Date : 2004-06-28
The Structure Of Biological Membranes written by Philip L. Yeagle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-28 with Medical categories.
Recent research has provided an abundance of new information on membrane biochemistry. Now more than ever, it is essential to update our current understanding of membrane structure and function to fully appreciate and apply these findings. Completely revised and updated to reflect advances in the field, The Structure of Biological Membranes,
Understanding Lung Acinar Micromechanics In Health And Disease Linking Quantitative Imaging And Organ Scale Mechanics By Computational Modeling
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Author : Matthias Ochs
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-26
Understanding Lung Acinar Micromechanics In Health And Disease Linking Quantitative Imaging And Organ Scale Mechanics By Computational Modeling written by Matthias Ochs and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-26 with Science categories.