Chromatin Proteins And Transcription Factors As Therapeutic Targets
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Chromatin Proteins And Transcription Factors As Therapeutic Targets
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-02-17
Chromatin Proteins And Transcription Factors As Therapeutic Targets written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-17 with Medical categories.
Chromatin Proteins and Transcription Factors as Therapeutic Targets, the latest volume in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in the field Contains chapters written by authorities Targeted to a wide audience of researchers, specialists, and students
Targets For Cancer Chemotherapy
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Author : Nicholas B. La Thangue
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-04-03
Targets For Cancer Chemotherapy written by Nicholas B. La Thangue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-03 with Medical categories.
In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
Eukaryotic Transcription Factors
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Author : David Latchman
language : en
Publisher: Academic Press
Release Date : 2010-07-28
Eukaryotic Transcription Factors written by David Latchman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-28 with Science categories.
Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. Potential of transcription factors as therapeutic targets in human disease Importance of histone modifications Use of genome-based sequence analysis and high-throughput methods Applications of the chromatin immunoprecipitation (ChIP) assay Transcriptional elongation Regulation by post-translational modifications Regulatory networks and bioinformatics
Chromosomal Translocations And Oncogenic Transcription Factors
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Author : Frank J. III Rauscher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chromosomal Translocations And Oncogenic Transcription Factors written by Frank J. III Rauscher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.
The Secret Lives Of Transcription Factors
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Author : Willis X. Li
language : en
Publisher: Springer Nature
Release Date : 2023-04-25
The Secret Lives Of Transcription Factors written by Willis X. Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-25 with Science categories.
This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Nuclear Signaling Pathways And Targeting Transcription In Cancer
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Author : Rakesh Kumar
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-23
Nuclear Signaling Pathways And Targeting Transcription In Cancer written by Rakesh Kumar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-23 with Medical categories.
At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.
Epigenomics From Chromatin Biology To Therapeutics
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2012
Epigenomics From Chromatin Biology To Therapeutics written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Epigenetics categories.
Experts from academia, the biotechnology and pharmaceutical industries introduce biological, medical and methodological aspects of the emerging field of epigenomics.
The Histone Code And Beyond
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Author : Shelley L. Berger
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19
The Histone Code And Beyond written by Shelley L. Berger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Science categories.
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Transcription Factors
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Author : S. Akira
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-27
Transcription Factors written by S. Akira and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Medical categories.
With contributions by numerous experts
Introduction To Epigenetics
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Author : Renato Paro
language : en
Publisher: Springer Nature
Release Date : 2021-03-23
Introduction To Epigenetics written by Renato Paro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Science categories.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease