Chromosome Structural Analysis
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Chromosome Structural Analysis
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Author : Wendy Bickmore
language : en
Publisher: OUP Oxford
Release Date : 1999-05-20
Chromosome Structural Analysis written by Wendy Bickmore and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-20 with Science categories.
The DNA of eukaryotes is packaged into chromosomes - each chromosome consisting of a very long molecule of DNA and various proteins (e.g. histones), and the number of chromosomes being characteristic for the species concerned. Chromosome analysis can provide a great deal of information for many aspects of cellular genetics such as DNA replication, protein:DNA interactions and genetic manipulation. The book is structured in a methodical fashion - the introductory chapters are centred around analysis of chromatin with chapters on the mapping of protein:DNA interactions in vivo using ligation-mediated PCR and the mapping of chromatin-associated proteins by formaldehyde cross-linking. The next chapters concentrate on the study of whole chromosome structure, including: fission yeast chromosome analysis using FISH and CHIP, isolation of vertebrate metaphase chromosomes and their analysis by FISH, the study of vertebrate chromosome progression through mitosis, and the analysis of mammalian interphase chromosomes by immunofluorescence and FISH. There then follow chapters on FISH in whole-mount tissues and the analysis of the sub-structure of mammalian nuclei in vitro. The final two chapters deal with the experimental manipulation of chromosome structure, including: chromosome assembly in vitro using Xenopus egg extracts and chromosome fragmentation in vertebrate cell lines. This comprehensive and informative laboratory manual includes a diverse range of experimental models for the analysis of chromosomes - such as vertebrates, Drosophila, yeast and Xenopus. Fully illustrated, it focuses on modern techniques and approaches to the study of chromosome structure and will be invaluable to researchers and academic staff in genetics, biomedical science and molecular biology.
Human Chromosome Atlas
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Author : Claudia Behrend
language : en
Publisher: Springer
Release Date : 2017-07-06
Human Chromosome Atlas written by Claudia Behrend and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-06 with Medical categories.
This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.
Chromosome Structure And Function
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Author : Andreas Houben
language : en
Publisher: Springer My Copy UK
Release Date : 2009
Chromosome Structure And Function written by Andreas Houben and has been published by Springer My Copy UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Aufsatzsammlung categories.
Our understanding of the function and structure of chromosomes and their interrelationship has grown in recent years. The chapters in this issue describe the advances that have been made possible by combining microscope techniques with sophisticated biochemical and genetic approaches to unlock the secrets of chromosomes. The authors look at many aspects of chromosome biology, such as protein, DNA and RNA composition of chromosomes, defined chromosome structures, unusual chromosome structures and specialized chromosomes and microscope tools for chromosome analysis. 'Chromosome Structure and Function' will be an invaluable resource for undergraduate and postgraduate students in fields such as plant and animal sciences, genetics, and molecular biology. In fact, any student, teacher or researcher interested in chromosome biology will find this special issue indispensable.
Chromosome Structure And Aberrations
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Author : Tariq Ahmad Bhat
language : en
Publisher: Springer
Release Date : 2017-02-08
Chromosome Structure And Aberrations written by Tariq Ahmad Bhat and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
This book is a compilation of various chapters contributed by a group of leading researchers from different countries and covering up to date information based on published reports and personal experience of authors in the field of cytogenetics. Beginning with the introduction of chromosome, the subsequent chapters on organization of genetic material, karyotype evolution, structural and numerical variations in chromosomes, B-chromosomes and chromosomal aberrations provide an in-depth knowledge and easy understanding of the subject matter. A special feature of the book is the inclusion of a series of chapters on various types of chromosomal aberrations and their impact on breeding behaviour and crop improvement. The possible mechanism, their consequences and role in genetic analysis has been emphasized in these chapters. A few chapters have also been dedicated on various techniques routinely used in the laboratory by students and researchers. Each chapter ends with an extensive bibliography so that the students and researchers may find it relevant to consult more literature on the subject than a book of this size can offer. The book is intended to fulfill the needs of undergraduate and post graduate students of botany, zoology and agriculture besides, teachers and researchers engaged in the field of genetics, cytogenetics, and molecular genetics. In general the readers will find each chapter of the book informative and easy to understand.
Eukaryotic Chromosomes
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Author : R. C. Sobti
language : en
Publisher:
Release Date : 1991
Eukaryotic Chromosomes written by R. C. Sobti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Chromosome abnormalities categories.
Some Aspects Of Chromosome Structure And Function
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Author : R.C. Sobti
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Some Aspects Of Chromosome Structure And Function written by R.C. Sobti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the carriers of genetic information. Subsequent studies, especially by Morgan and Bridges, established unequivocally the chromosome theory of inheritance. Today, the structure of chromosome is well established. At the physical level, eukaryotic chromosomes are composed of a single, linear, double helix of DNA. The elementary helical structure involves nucleosomes, comprised of histones around which the DNA is wrapped. A hierarchy of higher order of chromosomal architecture may possibly be responsible for the regulation of gene helical structures expression. The localized condensations of DNA constitute chromomeres. Uncoiled structures sometimes extending from chromomeres, which form loops, is the result of discontinuities in the regular coiling of the DNA in the chromosome.
Chromosome Analysis
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Author : Eisuke Gotoh
language : en
Publisher: Springer Nature
Release Date : 2022-09-06
Chromosome Analysis written by Eisuke Gotoh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-06 with Science categories.
This volume provides essential and fundamental protocols on manipulation chromosome. Chapters details methods on the preparation of mitotic chromosome, chromosome aberration, micronucleus (MN), comet assay, karyotyping, Fluorescent in situ hybridization (FISH), premature chromosome condensation (PCC), immunohistochemistry (IHC) staining, new generation sequencing technology and new chromosome concepts, such as epigenetic and its cause of cancer are presented. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chromosome Analysis: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Structural Analysis Of Dna Sequences
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Author : Armin Schmitt
language : de
Publisher:
Release Date : 1995
Structural Analysis Of Dna Sequences written by Armin Schmitt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with DNA categories.
Chromosome Structure And Function
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Author : Rudi Appels
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chromosome Structure And Function written by Rudi Appels and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A Historical Perspective on the Study of Chromosome Structure and Function R. Appels Division of Plant Industry CSIRO P.O. Box 1600 A.C.T. AUSTRALIA "Modern physical science gives us no model to explain the re duplication of the gene-string in each cell generation, or to ex plain the production of effective quantities of specific enzymes or other agents by specific genes. The precise pairing and inter change of segments by homologous gene-strings at meiosis also suggest novel physical properties of this form of matter". Stadler (1954) The very strong influence of reductionism in the history of understanding chromosome structure and function is evident in the above quotation from Stadler's 1954 paper, "The gene". Earlyob servations on the constancy of the cytological appearance of chromo somes and their regular behaviour in cell division led to specula tion on their biological importance. As genetics became more refined in the early decades of the 20th century the genes-on-a string model of chromosomes developed and greater emphasis was placed on the further dissection of these structures. As a result, in the 1980's the reductionist approach is reaching a crest as extensive regions of the genetic material are being sequenced.
Human Chromosomes
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Author : Eeva Therman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Chromosomes written by Eeva Therman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book provides an introduction to human cytogenetics. It is also suitable for use as a text in a general cytogenetics course, since the basic features of chromosome structure and behavior are shared by all eukar yotes. Because my own background includes plant and animal cytoge netics, many of the examples are taken from organisms other than man. Since the book is written from a cytogeneticist's point of view, human syndromes are described only as illustrations of the effects of abnormal chromosome constitutions on the phenotype. The selection of the phe nomena to be discussed and of the photographs to illustrate them is, in many cases, subjective and arbitrary and is naturally influenced by my interests and the work done in our laboratory. The approach to citations is the exact opposite of that usually used in scientific papers. Whenever possible, the latest and/or most comprehen sive review has been cited, instead of the original publication. Thus the reader is encouraged to delve deeper into any question of interest to him or her. I am greatly indebted to many colleagues for suggestions and criticism. However, my special thanks are due to Dr. JAMES F. CROW, Dr. TRAUTE M. SCHROEDER, and Dr. CARTER DENNISTON for their courage in reading the entire manuscript. I wish to express my gratitude also to the cytogeneticists and editors who have generously permitted the use of published and unpublished photographs.