Chromosome Studies In First Polar Bodies From Hamster And Human Oocytes
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Chromosome Studies In First Polar Bodies From Hamster And Human Oocytes
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Author : Mercè Durban
language : en
Publisher:
Release Date : 1998
Chromosome Studies In First Polar Bodies From Hamster And Human Oocytes written by Mercè Durban and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Human Oocytes And Their Chromosomes
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Author : B.-M. Uebele-Kallhardt
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Oocytes And Their Chromosomes written by B.-M. Uebele-Kallhardt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The last decade has seen remarkable advances in human ge netics. Once the correct chromosome number of the human genome was ascertained, a wide variety of diseases was rec ognized as due to numerical chromosome anomalies. There followed the discovery that spontaneous abortions are the result of chromosome errors, and specific band patterns of chromosomes allowed identification of minute lesions. The techniques of cell hybridization now allow specific gene assign ment to chromosomes and even to distinct loci on their arms. All this was possible because of the ease with which metaphase chromosomes can be obtained and manipulated. The much older technique of analysis of meiotic chromosomes has taken a back seat in this exciting era. Being much less readily accessi ble, spermatogonial analysis is much less frequently under taken and is less successful. Even more difficult for study is the female meiotic process. Not only is meiosis extraordinar ily long, spanning from before birth to ovulation, the tech niques for its study and the patience required for detailed inquiry have been significant obstacles. At the same time, the suspicion that female meiotic analysis should not only be rewarding but that it may be mandatory has been with us ever since it was recognized that a positive correlation exists between chromosomal nondisjunction and maternal age. Before the intricacies of chromosomal behavior that are re sponsible for nondisjunction are understood, however, it is necessary that we comprehend the normalcy of the process.
Aneuploidy Study Of Human Oocytes First Polar Body Comparative Genomic Hybridization And Metaphase Ii Fluorescence In Situ Hybridization Analysis
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Author : Cristina Mercedes Gutiérrez Mateo
language : en
Publisher:
Release Date : 2004
Aneuploidy Study Of Human Oocytes First Polar Body Comparative Genomic Hybridization And Metaphase Ii Fluorescence In Situ Hybridization Analysis written by Cristina Mercedes Gutiérrez Mateo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Analysis Of Nine Chromosome Probes In First Polar Bodies And Metaphase Ii Oocytes For The Detection Of Aneuploidies
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Author : Aïda Pujol Masana
language : en
Publisher:
Release Date : 2003
Analysis Of Nine Chromosome Probes In First Polar Bodies And Metaphase Ii Oocytes For The Detection Of Aneuploidies written by Aïda Pujol Masana and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Textbook Of Assisted Reproduction For Scientists In Reproductive Technology
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Author :
language : en
Publisher: Vivid Publishing
Release Date : 2009
Textbook Of Assisted Reproduction For Scientists In Reproductive Technology written by and has been published by Vivid Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Human reproductive technology categories.
Aneuploidy In Health And Disease
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Author : Zuzana Storchova
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-05-16
Aneuploidy In Health And Disease written by Zuzana Storchova and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-16 with Medical categories.
Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies.
Fluorescence In Situ Hybridization Fish Application Guide
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Author : Thomas Liehr
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-26
Fluorescence In Situ Hybridization Fish Application Guide written by Thomas Liehr and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-26 with Science categories.
This book is a unique source of information on the present state of the exciting field of molecular cytogenetics and how it can be applied in research and diagnostics. The basic techniques of fluorescence in situ hybridization and primed in situ hybridization (PRINS) are outlined, the multiple approaches and probe sets that are now available for these techniques are described, and applications of them are presented in 36 chapters by authors from ten different countries around the world. The book not only provides the reader with basic and background knowledge on the topic, but also gives detailed protocols that show how molecular cytogenetics is currently performed by specialists in this field. The FISH Application Guide initially provides an overview of the (historical) development of molecular cytogenetics, its basic procedures, the equipment required, and probe generation. The book then describes tips and tricks for making different tissues available for molecular cytogenetic studies. These are followed by chapters on various multicolor FISH probe sets, their availability, and their pot- tial for use in combination with other approaches. The possible applications that are shown encompass the characterization of marker chromosomes, cryptic cytogenetic aberrations and epigenetic changes in humans by interphase and metaphase cyto- netics, studies of nuclear architecture, as well as the application of molecular cytogenetics to zoology, botany and microbiology.
Chromosomal Complements In Human Immature And Mature Oocytes In Relation To Maternal Age
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Author : Wagdan Alenizy
language : en
Publisher:
Release Date : 2015
Chromosomal Complements In Human Immature And Mature Oocytes In Relation To Maternal Age written by Wagdan Alenizy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
"Numerical chromosome abnormalities significantly contribute to the high incidence of spontaneous abortions, stillbirths, and live births with congenital defects. The vast majority of these abnormalities are maternally related and attributed to meiotic errors occurring during oogenesis. The clinical relevance of these errors, the contribution to the overall rate of chromosome abnormalities, and the association with advanced maternal age are well documented. Maternally related chromosome abnormalities can also be attributed to errors occurring prior to meiosis. Select studies have estimated the incidence of pre-meiotic mitotic errors, though the prevalence, clinical relevance, and association with maternal age remain unknown. Therefore, we aimed to investigate the incidence of pre-meiotic mitotic errors in human immature and mature oocytes derived from women who underwent controlled ovarian hyperstimulation (COH) treatment cycles in relation to maternal age. FISH-based analysis for chromosomes most frequently involved in pregnancy loss (13, 15, 16, 18, 21, 22, and X) was applied to analyze the chromosomal complements in human oocytes. We pioneered a method in developing and validating the FISH signals scoring criteria of chromosomally normal immature oocytes at different maturation stages (in relation to maternal age) by plotting histograms of FISH signals per tested chromosome. These distributions allowed us to determine the possibility of sample variation, as well as confirmed our FISH signals scoring criteria for chromosomally normal oocytes. The overall rates of chromosomally normal immature oocytes at all different maturation stages were comparable between both maternal age groups, suggesting that pre-meiotic mitotic errors are not maternal-age dependent. We re-analyzed the data to estimate the incidence of chromosomally normal immature oocytes at the different maturation stages (in relation to maternal age) when each patient donated "sibling oocytes" for eliminating patient bias. These results confirmed that pre-meiotic mitotic errors are not associated with maternal age. Our findings indicate that the incidence of pre-meiotic mitotic errors in human mature oocytes with the corresponding first polar bodies in relation to maternal age is considerably low compared to first meiotic errors. As previously reported, the overall rate of first meiotic errors is directly related to maternal age. Our data suggest that although the contribution of pre-meiotic mitotic errors to the overall rate of maternally related chromosome abnormalities is relatively low, consequences of these errors have clinical relevance to human fertility, at least in our study population. " --
The Perinatal Medicine Of The New Millenium
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Author : José María Carrera
language : en
Publisher:
Release Date : 2001
The Perinatal Medicine Of The New Millenium written by José María Carrera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.