Community Series In Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis Volume Ii
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Community Series In Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis Volume Ii
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Author : Jialin C. Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-31
Community Series In Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis Volume Ii written by Jialin C. Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-31 with Medical categories.
This Research Topic is the second volume of the "Inflammation in Respiratory and Neurological Diseases and the immune-interaction of the lung-brain axis" Community Series. Please see volume I here. Despite great advances in diagnosis and treatment that we have witnessed in the last decades, over a billion people suffer from both respiratory and neurological diseases each year, which poses great threats to public health and economic burden worldwide. In many instances, the underlying pathogenic mechanisms are still poorly understood, which significantly limits the efficacy of therapeutic methods. In this regard, lines of evidence pinpoint the important role of immunity and inflammation in both respiratory disorders (e.g., pulmonary hypertension, chronic obstructive pulmonary disease, asthma, etc.) and neurological ones (e.g., neurodegenerative diseases, stroke, depression, etc.). The accumulation of inflammatory cells and an excess of cytokines and chemokines at the inflammatory site would result from the disturbance of the body's delicate balance between immunity and tolerance. Therefore, it gives rise to chronic inflammation and autoimmunity underlying the development of both lung and neurological diseases. Furthermore, the inflammation interaction between lung and brain has been identified, suggesting the existence and importance of the lung-brain axis in the regulation of immune responses in the lung and brain that contribute to the onset and progression of both respiratory and neurological diseases. Nevertheless, inflammatory or immunity related risk factors as well as novel targets and therapies against inflammation or immunity help early diagnosis and treatment of respiratory and neurological diseases. At present, the full picture of the molecular mechanisms of how immuno-inflammatory activation and the immune cells orchestrate the tissue remodeling leading to respiratory and neurological diseases remains unclear. The identification of inflammatory molecules as therapeutic targets or biomarkers are worth further scrutiny to halt the disease progression and monitor the therapeutic interventions. The goal of this Research Topic is to provide an overview of the immunomodulatory mechanisms, novel targets, and therapies against the inflammatory mediators, the inflammatory interaction between lung and brain as well as inflammation-related risk factors in respiratory and neurological diseases. It will enhance our comprehension of immunity as a crucial player in the crosstalk between the lung and brain under physiological and pathological conditions. We welcome the submission of Review, Original Research articles, and Clinical Trial data that cover, but are not limited to, the following topics: (1) Immunity and inflammation related mechanisms in respiratory and neurological diseases. (2) Novel targets against inflammation or immunity in respiratory and neurological diseases. (3) Novel therapies (e.g., exosomes, engineered immunomodulatory agents, nanomaterials) against inflammation or immunity in respiratory and neurological disorders. (4) The inflammatory interactions of lung and brain under physiological and pathological conditions. (5) The identification of inflammation- or immunity-related risk factors (traditional and genetic) contributing to respiratory and neurological diseases for the development of novel biomarkers for disease diagnosis and prognosis.
Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis
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Author : Xiaohuan Xia
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-18
Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis written by Xiaohuan Xia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-18 with Medical categories.
Despite great advances in diagnosis and treatment that we witnessed in the last decades, over a billion people suffer from both respiratory and neurological diseases each year, which poses great threats to the public health and economic burden worldwide. In many instances, the underlying pathogenic mechanisms are still poorly understood, which significantly limits the efficacy of therapeutic methods. In this regard, lines of evidence pinpoint the important role of immunity and inflammation in both respiratory disorders (e.g., pulmonary hypertension, chronic obstructive pulmonary disease, asthma, etc.) and neurological ones (e.g., neurodegenerative diseases, stroke, depression, etc.). The accumulation of inflammatory cells and an excess of cytokines and chemokines at the inflammatory site would result from the disturbance of the body's delicate balance between immunity and tolerance. Therefore, it gives rise to chronic inflammation and autoimmunity underlying the development of both lung and neurological diseases. Furthermore, the inflammation interaction between lung and brain has been identified, suggesting the existence and importance of the lung-brain axis in the regulation of immune responses in the lung and brain that contribute to the onset and progression of both respiratory and neurological diseases. Nevertheless, inflammatory or immunity related risk factors as well novel targets and therapies against inflammation or immunity help early diagnosis and treatment of respiratory and neurological diseases. At present, the full picture of the molecular mechanisms of how immuno-inflammatory activation and the immune cells orchestrate the tissue remodeling leading to respiratory and neurological diseases remains unclear. The identification of inflammatory molecules as therapeutic targets or biomarkers are worth further scrutiny to halt the disease progression and monitor the therapeutic interventions.
Lung Inflammation In Health And Disease Volume I
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Author : Yong-Xiao Wang
language : en
Publisher: Springer Nature
Release Date : 2021-03-31
Lung Inflammation In Health And Disease Volume I written by Yong-Xiao Wang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-31 with Medical categories.
Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
Interactions Of The Gut Microbiota And The Innate Immune System
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Author : Daniel Erny
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-19
Interactions Of The Gut Microbiota And The Innate Immune System written by Daniel Erny and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-19 with Science categories.
The Lung Microbiome
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Author : Michael J. Cox
language : en
Publisher: European Respiratory Society
Release Date : 2019-03-01
The Lung Microbiome written by Michael J. Cox and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-01 with Medical categories.
Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Pediatric And Neonatal Mechanical Ventilation
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Author : Peter C. Rimensberger
language : en
Publisher: Springer
Release Date : 2014-11-12
Pediatric And Neonatal Mechanical Ventilation written by Peter C. Rimensberger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-12 with Medical categories.
Written by outstanding authorities from all over the world, this comprehensive new textbook on pediatric and neonatal ventilation puts the focus on the effective delivery of respiratory support to children, infants and newborns. In the early chapters, developmental issues concerning the respiratory system are considered, physiological and mechanical principles are introduced and airway management and conventional and alternative ventilation techniques are discussed. Thereafter, the rational use of mechanical ventilation in various pediatric and neonatal pathologies is explained, with the emphasis on a practical step-by-step approach. Respiratory monitoring and safety issues in ventilated patients are considered in detail, and many other topics of interest to the bedside clinician are covered, including the ethics of withdrawal of respiratory support and educational issues. Throughout, the text is complemented by numerous illustrations and key information is clearly summarized in tables and lists.
Sleep Disorders And Sleep Deprivation
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-10-13
Sleep Disorders And Sleep Deprivation written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-13 with Medical categories.
Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Immune Biology Of Allogeneic Hematopoietic Stem Cell Transplantation
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Author : Gerard Socie
language : en
Publisher: Academic Press
Release Date : 2018-11-22
Immune Biology Of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-22 with Science categories.
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Causes Of Sleep Complaints An Issue Of Sleep Medicine Clinics E Book
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Author : Keith Aguilera
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-03-02
Causes Of Sleep Complaints An Issue Of Sleep Medicine Clinics E Book written by Keith Aguilera and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-02 with Medical categories.
In this issue of Sleep Medicine Clinics, guest editors Keith Aguilera and Agnes Remulla bring their considerable expertise to the topic of Causes of Sleep Complaints. Their team at St. Luke's Sleep Medicine and Research Center is skilled in the diagnosis and treatment of all types of sleep disorders in patients of all ages. In this issue, experts share their knowledge on insomnia; sleep disturbances related to genetic disorders, COPD, heart failure, obesity, and dementia; sleep health and road safety, and more. - Contains 13 relevant, practice-oriented topics including disrupted sleep during a pandemic; sleep disturbances during shift work; sleep disturbances in pregnancy; snoring: evaluation and management; sleep complaints among school children; and more. - Provides in-depth clinical reviews on causes of sleep complaints, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Functional Illness Of The Head And Neck
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Author : Brian W. Blakley
language : en
Publisher: Springer Nature
Release Date : 2023-03-02
Functional Illness Of The Head And Neck written by Brian W. Blakley and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-02 with Medical categories.
This book uniquely discusses an approach to illnesses for which the causes are unknown. It fills the gaps in the literature by relaying research on functional illness, identifying and assessing various options, and indicating some decision-making suggestions that should help clinicians and patients think about therapy. Special considerations for functional illness include “probability” explanations based on the experience of others, serious consideration of the severity of symptoms before treatments are applied, and balancing the risks, costs, and consequences of treatment; including the patient’s thoughts and attitudes is critical for success in treating functional illness. Unique and comprehensive, Functional Illness is an invaluable reference for medical physicians of all specialties who wish to understand better and identify functional illness symptoms.