Community Series In Progress Of Allo And Xeno Transplantation Facilitating The Initial Xeno Kidney And Islet Clinical Trials Volume Ii
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Community Series In Progress Of Allo And Xeno Transplantation Facilitating The Initial Xeno Kidney And Islet Clinical Trials Volume Ii
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Author : Lisha Mou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-21
Community Series In Progress Of Allo And Xeno Transplantation Facilitating The Initial Xeno Kidney And Islet Clinical Trials Volume Ii written by Lisha Mou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-21 with Medical categories.
Owing to the availability of more advanced genetically engineered pigs, more immunological and physiological barriers have been overcome. With the results of pig organ xenotransplantation steadily improving, consideration is now given to the first clinical trials of xenotransplantation. The first step is kidneys, but possibilities also exist in pig islet transplantation for patients with diabetes.
Progress Of Allo And Xeno Transplantation Facilitating The Initial Xeno Kidney And Islet Clinical Trials
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Author : Burcin Ekser
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-11
Progress Of Allo And Xeno Transplantation Facilitating The Initial Xeno Kidney And Islet Clinical Trials written by Burcin Ekser and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-11 with Medical categories.
Transplantation Surgery
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Author : Nadey Hakim
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-03-10
Transplantation Surgery written by Nadey Hakim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-10 with Medical categories.
It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.
Small Animal Imaging
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Author : Fabian Kiessling
language : en
Publisher: Springer
Release Date : 2017-05-22
Small Animal Imaging written by Fabian Kiessling and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Cryopreservation And Freeze Drying Protocols
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Author : John G. Day
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-05
Cryopreservation And Freeze Drying Protocols written by John G. Day and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-05 with Science categories.
In addition to outlining the fundamental principles associated with the conservation of biological resources, freeze-drying and cryopreservation, this text is a compilation of cryptopreservation and freeze-drying methodologies applicable to different biological materiels, developed by expert laboratories.
Applied Basic Science For Basic Surgical Training E Book
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Author : Andrew T Raftery
language : en
Publisher: Elsevier Health Sciences
Release Date : 2011-12-22
Applied Basic Science For Basic Surgical Training E Book written by Andrew T Raftery and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-22 with Medical categories.
This title is directed primarily towards health care professionals outside of the United States. It has been written to encompass the basic anatomy, physiology and pathology required by the syllabus of the UK Royal Colleges and the Intercollegiate Surgical Curriculum Project. For this Second Edition many of the chapters have been updated, especially the chapters on immunology, basic microbiology, the endocrine and locomotor systems and the breast. An attempt has been made throughout to indicate the clinical relevance of the facts and the reason for learning them. There are several new contributors to the author team, all of whom are experts in their field and many of them are, or have been, experienced examiners at the various UK Royal Colleges. Brings together three basic sciences in one book and presents them in an integrated format. Presents the sciences at the right level for surgical trainees. Written in a straightforward and readable style. Thoroughly revised to take account of latest changes in basic surgical training, especially the chapters on immunology, basic microbiology, the endocrine and locomotor systems and the breast
Natural Bio Active Compounds
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Author : Mallappa Kumara Swamy
language : en
Publisher: Springer Nature
Release Date : 2019-09-19
Natural Bio Active Compounds written by Mallappa Kumara Swamy and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-19 with Science categories.
Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.
Biotechnology In Surgery
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Author : Alfonso Barbarisi
language : en
Publisher: Springer
Release Date : 2012-12-01
Biotechnology In Surgery written by Alfonso Barbarisi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-01 with Medical categories.
The 20th century has finished, the century when surgery took huge steps forward thanks to progress in technology. Now we have entered the "century of biotechnologies", which will not only generate progress in surgery, but also lead to a real "cultural revolution" that will completely change approaches to solving different problems in medicine. The aim of this book is to bring surgeons closer to biotechnologies and to overcome the cultural gap dividing them from these new approaches. Biotechnologies are already proposed and used at different levels in surgical practice: in diagnostic technique, enabling practitioners to identify diseases at an early stage and follow their molecular modification over time; and in tissue engineering, where the use of "smart scaffolds" offers a possible answer to increasing demand for biocompatible tissues and organs in transplantation surgery. This volume focuses on the emerging field of stem cells, analyzing both their role as possible players in originating and perpetuating cancer – "cancer stem cells" – and, conversely, their extraordinary therapeutical potential. An additional section is dedicated to the evaluation and application of derived molecular factors that can enhance the physiological processes that are fundamentally important in surgery, such as hemostasis and wound healing. Surgeons have always been technologists, in the sense that since surgery began they have always needed technology, beginning with a scalpel and surgical instruments. They have always cooperated with technologists. However, in the new century, the first one of the millennium, a rapid increase in knowledge that is outside the realm of the surgeon’s traditional technological training is imposing itself – hence the aim of this book. It is now urgent to encourage surgeons to embrace this knowledge (biotechnology) with confidence. By its very nature, biotechnology is completely different from the technologies used so far, because it escapes the senses of sight and touch, which up to now have been the essence of the surgeon’s work. The cellular and molecular dimensions of biotechnologies are still far removed from most of the recent advances in modern surgical techniques. A common language between surgeons and biotechnologists will create further, revolutionary, progress in surgical sciences in the twenty-first century.
Clinical Xenotransplantation
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Author : David K. C. Cooper
language : en
Publisher: Springer Nature
Release Date : 2020-09-08
Clinical Xenotransplantation written by David K. C. Cooper and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-08 with Medical categories.
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
Xenotransplantation
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Author : Shuji Miyagawa
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Xenotransplantation written by Shuji Miyagawa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Technology & Engineering categories.
Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.