Comparative Neuropathology Of Chronic Experimental Allergic Encephalomyelitis And Multiple Sclerosis
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Comparative Neuropathology Of Chronic Experimental Allergic Encephalomyelitis And Multiple Sclerosis
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Author : H. Lassmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Comparative Neuropathology Of Chronic Experimental Allergic Encephalomyelitis And Multiple Sclerosis written by H. Lassmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
For several decades the unsolved etiogenetic and therapeutic problems of multiple sclerosis have offered the strongest challenge to research in neu rology. The hope of decisive theoretical and practical progress increased when an experimental model presenting far-reaching conformity of structural and pathogenetic features was developed, namely chronic re lapsing experimental allergic encephalomyelitis (CREAE). During the past years, Dr. Lassmann has contributed substantially to the adaptation of this model with the aim of comprehensive evaluation, thoroughly fol lowing up his own ideas in numerous studies of individual aspects. The new possibility of continuous and detailed investigation of the clinical, morphological and immunological characteristics of temporal phase sequence of autoimmune demyelination has led to many new findings, corrections offormer hypotheses, and, from correlated studies of human multiple sclerosis, a series of important data concerning, for example, early manifestations of demyelination, the range of so-called acute mul tiple sclerosis and the incidence of remyelination. Moreover, Dr. Lass mann has analysed several special problems which became definable in the course of his own studies or in collaboration with other groups, in cluding the initial distribution of demyelinated foci, the cerebrospinal fluid phenomena and immunological findings in the nervous tissue. The results of these separate studies also led to a deeper understanding of demyelinating processes. This monograph integrates these studies and summarizes their re sults.
Comparative Neuropathology Of Chronic Experimental Allergic Encephalomyelitis And Multiple Sclerosis
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Author : H Lassmann
language : en
Publisher:
Release Date : 1983-07-01
Comparative Neuropathology Of Chronic Experimental Allergic Encephalomyelitis And Multiple Sclerosis written by H Lassmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983-07-01 with categories.
Multiple Sclerosis
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Author : G. Scarlato
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Multiple Sclerosis written by G. Scarlato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
This book is based on the papers delivered at an International Workshop on Multiple Sclerosis held in Erice, Italy from 29th August to 1st September 1983. The Meeting was organized with great efficiency in the delightful setting of the Centro di Cultura Scientifica Ettore Mahorana, by its Director, Antonino Zichichi, and was directed by the Editors of the Proceedings and by Professor C. Alvisi of the University of Bologna. The emphasis was deliberately on the contributions of laboratory science to the understanding of mUltiple sclerosis, its etiology, pathogenesis, diagnosis and treatment. Where so much is unknown, disagreement was expected and indeed welcome, and it is regrettable that it was not possible to publish verbatim the often animated and always interesting discussion. Differing views on the relevance of experimental allergic encephalomyelitis to multiple sclerosis were expressed by Dr. Wisniewski, Professor Seitelberger and Professor Alvord, who graphi cally illustrated his changing beliefs over the years. Professor Seitelberger laid much greater emphasis on remyelination in remission in mUltiple sclerosis than had previously been the accepted view. The disorder of both humoral and cellular immunity in multiple scler osis was discussed by Dr. Roos and Professor Link. Dr. Gilden described how recombinative techniques might be applied to the detec tion of a virus in multiple sclerosis. The continued inability to detect any antigen to match the oligoclonal IgG bands in the CSF in multiple sclerosis patients was disappointing and there was an increasing tendency to regard the bands as "nonsense" antibodies.
A Multidisciplinary Approach To Myelin Diseases
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Author : G. Crescenzi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
A Multidisciplinary Approach To Myelin Diseases written by G. Crescenzi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The present book is based on the papers presented during an inter disciplinary meeting which was held in Rome October 27-30, 1986, at the Istituto Superiore di Sanita under the sponsorship of NATO, and with a financial contribution of the Cassa di Risparmio di Roma. The meeting was of great interest because, for the first time, a group of highly qualified scientists specializing in different fields were gathered together to discuss the problem of demyelinating diseases. In thi. context molecular biologists, immunologists, virologists, and lipid chemists could discuss with clinicians for four days every aspect of demyelinating diseases. They shared results of the more recent research with the hope that more knowledge of the myelinating process will eventually succeed in finding new treatments for these diseases. The meeting was successful, perhaps in part because discussions during lunches and dinners provided an opportunity for the exchange of new ideas. This was apparent in the discussions held after the presen tation of each paper and was summarized in the very lively round table which was held on the last day. The editor wishes to express his thanks to the scientific committee members: N. Baumann, C. Fieschi, G. Macchi, J.M. Matthieu, K. Suzuki. It was their advice that made the choice of participants and subjects so successful. The organizer also acknowledge the organizing support of NATO in preparing these proceedings. Acknowledgments have to be offered to Dr. S. Salvati, Dr. A.M.
Multiple Sclerosis As A Neuronal Disease
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Author : Stephen Waxman
language : en
Publisher: Elsevier
Release Date : 2005-05-27
Multiple Sclerosis As A Neuronal Disease written by Stephen Waxman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-27 with Medical categories.
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced
Inflammation And Demyelination In The Central Nervous System
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Author : B. H. Waksman
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Inflammation And Demyelination In The Central Nervous System written by B. H. Waksman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso ciated with perivascular inflammatory infilrates and is dimin ished by immunosuppressive measures. Remyelination by oligo dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local ized within oligodendrocytes.
Multiple Sclerosis Research In Europe
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Author : O.R. Hommes
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Multiple Sclerosis Research In Europe written by O.R. Hommes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Multiple sclerosis is an unique disease with a tremendous impact on social life in countries with moderate climates. Its cause is unknown. In recent years however hopes have been raised that the disease might be fought, and possibly cured. With the disappearance of poliomyelitis as the main paralyzing disease multiple sclerosis has taken its place as the single disease that is responsible for paralyzing the young with an incurable affliction of long duration, for social disruption and for an 1 economic impact that is estimated to be higher than heart disease • A multi-national, mUlti-disciplinary approach to this extremely disabling disease is urgently needed in this phase of hopeful scientific developments. The Commission of the European Communities therefore sponsored a Con ference on Multiple Sclerosis Research in Europe on 29,30 and 31 January 1985 in Nijmegen, The Netherlands, with the aim of formulating practical proposals for such cooperation in the Communities. This volume contains the papers read at that conference.
Perspectives On Autoimmunity
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Author : Irun R. Cohen
language : en
Publisher: CRC Press
Release Date : 2020-04-15
Perspectives On Autoimmunity written by Irun R. Cohen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Health & Fitness categories.
First Published in 1988, this book offers a full, comprehensive guide to autoimmunity. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine, and other practitioners in their respective fields.
A Multidisciplinary Approach To Myelin Diseases Ii
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Author : S. Salvati
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
A Multidisciplinary Approach To Myelin Diseases Ii written by S. Salvati and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The diseases that fall under the generalized group of demyelinating diseases -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the focus of worldwide concern. This volume contains papers presented by leading scientists who attended the NATO Advanced Research Workshop held at the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This book is an update of the previous one published in 1987 of the research discussed at a similar meeting held in 1986. It was decided to hold this 2nd meeting since there has been great progress in the advances in understanding the myelinogenesis process in the last five years. The workshop gathered together scientists from many fields such as cellular and molecular biology, immunology, pathology, virology and of course clinical neurology. Stimulating ideas were exchanged in the hope that more knowledge of demyelinating diseases can lead to new theraupetic approaches. Although the workshop was on the whole similar to the previous one, this time there was more emphasis on experimental models and clinical aspects. In the former the use of animal and cellular models as tools for understanding the pathological mechanisms linked to human disease were discussed; in the latter the clinicians described the filtering down of basic research to clinical treatment The publication of this interdisciplinary exchange is to make known the results of the most recent research among the investigators from allover the world involved in these studies.
Neuronal Grafting And Alzheimer S Disease
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Author : F.H. Gage
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
Neuronal Grafting And Alzheimer S Disease written by F.H. Gage and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease.
