Computational And Experimental Studies In Alzheimer S Disease
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Computational And Experimental Studies In Alzheimer S Disease
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Author : Kunal Bhattacharya
language : en
Publisher: CRC Press
Release Date : 2024-03-29
Computational And Experimental Studies In Alzheimer S Disease written by Kunal Bhattacharya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-29 with Science categories.
This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer’s disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer’s disease. Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer’s agents Explains the role of phytomolecules and natural products in Alzheimer’s therapy Reviews preclinical ways to assess drugs focusing on Alzheimer’s disease Covers biomarker analysis for Alzheimer’s disease Discusses the onset and progression of Alzheimer’s disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.
Computational And Experimental Simulations In Engineering
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Author : Shaofan Li
language : en
Publisher: Springer Nature
Release Date : 2023-11-30
Computational And Experimental Simulations In Engineering written by Shaofan Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-30 with Technology & Engineering categories.
This book gathers the latest advances, innovations, and applications in the field of computational engineering, as presented by leading international researchers and engineers at the 29th International Conference on Computational & Experimental Engineering and Sciences (ICCES), held in Shenzhen, China on May 26-29, 2023. ICCES covers all aspects of applied sciences and engineering: theoretical, analytical, computational, and experimental studies and solutions of problems in the physical, chemical, biological, mechanical, electrical, and mathematical sciences. As such, the book discusses highly diverse topics, including composites; bioengineering & biomechanics; geotechnical engineering; offshore & arctic engineering; multi-scale & multi-physics fluid engineering; structural integrity & longevity; materials design & simulation; and computer modeling methods in engineering. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerousexciting ideas that will spur novel research directions and foster multidisciplinary collaborations.
Biophysical And Computational Tools In Drug Discovery
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Author : Anil Kumar Saxena
language : en
Publisher: Springer Nature
Release Date : 2021-10-18
Biophysical And Computational Tools In Drug Discovery written by Anil Kumar Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-18 with Science categories.
This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.
The Alzheimer S Disease Challenge Volume Ii
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Author : Mohammad Amjad Kamal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
The Alzheimer S Disease Challenge Volume Ii written by Mohammad Amjad Kamal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.
Alzheimer S Disease From Molecular Mechanisms To Clinical Practices
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Author : Dildar Konukoğlu
language : en
Publisher: Nobel Tıp Kitabevi
Release Date :
Alzheimer S Disease From Molecular Mechanisms To Clinical Practices written by Dildar Konukoğlu and has been published by Nobel Tıp Kitabevi this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
“Alzheimer’s Disease: From Molecular Mechanisms to Clinical Practices” explores the extensive perspective from the molecular foundations to the clinical diagnosis and treatment of Alzheimer’s disease. The book serves as a fundamental resource for understanding the neurobiological basis and molecular pathogenesis of Alzheimer’s, while also discussing the challenges and opportunities of transitioning from the laboratory to clinical settings. The initial sections of the book comprehensively examine the fundamental molecular characteristics of Alzheimer’s disease; these include the accumulation of amyloid-beta peptide, hyperphosphorylation of tau protein, and how these processes lead to synaptic dysfunction and neuronal death. These chapters provide strategies on how to understand the pathology of the disease at a molecular level and how this knowledge can be translated into clinical practice. Subsequent parts focus on the development and use of biomarkers for the early diagnosis of Alzheimer’s disease. In addition to the role of genetic predispositions, the effects of environmental factors and lifestyle choices on Alzheimer’s disease are discussed, highlighting the multifactorial nature of the disease. In conclusion, this book is a valuable resource for clinicians, researchers, and medical students specializing in the field. It provides essential scientific and practical information necessary for a better understanding and management of Alzheimer’s disease, offering a comprehensive perspective on the integration of molecular mechanisms with clinical applications.
Alzheimer S Disease
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Author : Philippe Derreumaux
language : en
Publisher: World Scientific
Release Date : 2013
Alzheimer S Disease written by Philippe Derreumaux and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of brain lesions in dead and dying neurons, and by elevated numbers of amyloid deposits in the walls of cerebral blood vessels. This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of oligomerisation and fibril formation.
Biosensors Nanotechnology
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Author : Inamuddin
language : en
Publisher: John Wiley & Sons
Release Date : 2023-09-13
Biosensors Nanotechnology written by Inamuddin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Technology & Engineering categories.
BIOSENSORS NANOTECHNOLOGY The second edition of Biosensors Nanotechnology comprises 20 chapters and discusses a wide range of applications exploited by biosensors based on nanoparticles including new domains of bionics, power production and computing. The biosensor industry began as a small, niche activity in the 1980s and has since developed into a large, global industry. Nanomaterials have substantially improved not only non-pharmaceutical and healthcare uses, but also telecommunications, paper, and textile manufacturing. Biological sensing assists in the understanding of living systems and is used in a variety of sectors, including medicine, drug discovery, process control, environmental monitoring, food safety, military and personal protection. It allows for new opportunities in bionics, power generation and computing, all of which will benefit from a greater understanding of the bio-electronic relationship, as advances in communications and computational modeling enable us to reconsider how healthcare is offered and R&D and manufacturing are enhanced. In this fast-evolving discipline, the combination of nanoscale materials with biosensor technology has gained a lot of traction. Nanostructures have been used to increase the adherence of biosensor materials to electrode surfaces, print nano barcodes on biomaterials, increase the pace of bio-responses, and amplify the electric signal. Some of the topics discussed in the book include: Bioreceptors for Cells; Bioreceptors for Enzymatic Interactions; Dendrimer-Based Nanomaterials for Biosensors; Biosensors in 2D Photonic Crystals; Bioreceptors for Affinity Binding in Theranostic Development; Biosensors for Glucose Monitoring; Metal-Free Quantum Dots-Based Nanomaterials for Biosensors; Bioreceptors for Microbial Biosensors; Plasmonic Nanomaterials in Sensors; Magnetic Biosensors; Biosensors for Salivary Biomarker Detection of Cancer and Neurodegenerative Diseases; Design and Development of Fluorescent Chemosensors for the Recognition of Biological Amines and Their Cell Imaging Studies; Application of Optical Nanoprobes for Supramolecular Biosensing; In Vivo Applications for Nanomaterials in Biosensors; Biosensor and Nanotechnology for Diagnosis of Breast Cancer; Bioreceptors for Antigen–Antibody Interactions; Biosensors for Paint and Pigment Analysis; Bioreceptors for Tissue; Biosensors for Pesticide Detection; and Advances in Biosensor Applications for Agroproducts Safety. Audience The book is written for a large and broad readership including researchers, industry engineers, and university graduate students from diverse backgrounds such as chemistry, materials science, physics, pharmacy, medical science, biomedical engineering, electronics engineering, and nanotechnology.
Alzheimer S Disease
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Author : Thimmaiah Govindaraju
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-01-12
Alzheimer S Disease written by Thimmaiah Govindaraju and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-12 with Medical categories.
Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.
Alzheimer S Disease Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments Molecular Basis Of Amyloid Beta Protein Aggregation And Fibril Formation
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Author : Philippe Derreumaux
language : en
Publisher: World Scientific
Release Date : 2012-12-31
Alzheimer S Disease Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments Molecular Basis Of Amyloid Beta Protein Aggregation And Fibril Formation written by Philippe Derreumaux and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease./a
Computational Approaches For Ageing And Age Related Diseases
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Author : Stanley Durrleman
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-11
Computational Approaches For Ageing And Age Related Diseases written by Stanley Durrleman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Science categories.