Computational Drug Discovery For Emerging Viral Infections
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Computational Drug Discovery For Emerging Viral Infections
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Author : Sinosh Skariyachan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-05
Computational Drug Discovery For Emerging Viral Infections written by Sinosh Skariyachan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-05 with Science categories.
Human Herpesviruses
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Author : Ann Arvin
language : en
Publisher: Cambridge University Press
Release Date : 2007-08-16
Human Herpesviruses written by Ann Arvin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Antiviral Drug Discovery And Development
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Author : Xinyong Liu
language : en
Publisher: Springer Nature
Release Date : 2021-07-13
Antiviral Drug Discovery And Development written by Xinyong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Medical categories.
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Drug Repurposing And Computational Drug Discovery
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Author : Mithun Rudrapal
language : en
Publisher: CRC Press
Release Date : 2023-10-27
Drug Repurposing And Computational Drug Discovery written by Mithun Rudrapal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-27 with Medical categories.
Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates. This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases. With contributions from a global team of experts (academicians, scientists, and researchers), it explores the sophisticated tools and techniques of drug repurposing and computational drug discovery. It delivers valuable information on computational techniques, tools, and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases. Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial, fungal, viral, COVID-19), parasitic diseases and neglected tropical diseases (NTDs), malignant diseases (cancer), inflammatory diseases, cardiovascular disorders, diabetes, and aging and neurological (CNS) disorders. In addition, the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at, offering perspectives for future directions.
Emerging And Re Emerging Viral Diseases
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Author : Srijan Goswami
language : en
Publisher: CRC Press
Release Date : 2025-07-21
Emerging And Re Emerging Viral Diseases written by Srijan Goswami and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-21 with Science categories.
This reference book offers an in-depth analysis of the fundamental aspects, causative agents, and clinical manifestations of emerging and re-emerging infectious diseases of viral origin (EID-REID). It elucidates the role of evolutionary processes in the emergence, adaptation, and dissemination of pathogens. The initial chapter explores the causative agents behind EID-REID, providing a comprehensive overview of their origins, characteristics, and modes of transmission. The book further presents the structure, pathophysiology, and clinical presentation of various viral pathogens, including notable viruses such as the Crimean-Congo hemorrhagic fever Orthonairovirus (CCHFV), Rift Valley fever virus, Lassa virus, Nipah virus (NiV), Filoviridae, and coronaviruses (MERS, SARS, SARS-CoV-2). Additionally, the book elucidates the multifaceted landscape of treatment strategies, highlighting the pivotal role of pharmacological strategies, investigational drugs, vaccines, and immunomodulatory approaches. It also underscores the importance of clinical examination, immunoassays, and molecular diagnostic techniques for the early detection and accurate diagnosis of viral EID-REID. Toward the end, the book sheds light on the pivotal role of the Ayurveda, homoeopathic system of medicine, medical nutrition therapy, computational biology, bioinformatics, and systems biology in advancing disease management paradigms. This book is intended for epidemiologists, virologists, infectious disease specialists, and other healthcare practitioners who seek in-depth knowledge about emerging and re-emerging infectious diseases.
Drug Repurposing
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Author : Farid A. Badria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-12-02
Drug Repurposing written by Farid A. Badria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Medical categories.
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.
New Drug Development For Known And Emerging Viruses
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Author : Helga Rübsamen-Schaeff
language : en
Publisher: John Wiley & Sons
Release Date : 2021-11-30
New Drug Development For Known And Emerging Viruses written by Helga Rübsamen-Schaeff and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.
Computational Genomics And Structural Bioinformatics In Personalized Medicines
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26
Computational Genomics And Structural Bioinformatics In Personalized Medicines written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Medical categories.
Frontiers In Computational Chemistry Volume 7
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Author : Zaheer Ul-Haq
language : en
Publisher: Bentham Science Publishers
Release Date : 2024-11-20
Frontiers In Computational Chemistry Volume 7 written by Zaheer Ul-Haq and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-20 with Science categories.
Frontiers in Computational Chemistry (Volume 7) offers a comprehensive overview of the latest advances in molecular modeling techniques for drug discovery and development. This book focuses on key computational approaches such as rational drug design, adsorption studies, quantum mechanical calculations, and molecular interactions in drug development. It provides insights into lead generation, optimization, and the creation of novel chemical entities targeting various biological mechanisms, including inflammation. The chapters explore modern computational tools and their applications, particularly in low and middle-income countries (LMICs). The book is essential for researchers, academics, and professionals in computational chemistry, molecular modeling, and pharmaceutical sciences.Students and researchers.
New Topics In Vaccine Development
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-10-23
New Topics In Vaccine Development written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-23 with Medical categories.
New Topics in Vaccine Development explores the latest advancements and future directions in vaccinology across 11 chapters, each addressing a different and specific facet. This book is an essential resource for clinicians, researchers, scientists, and students in immunology aiming to deepen their understanding of this crucial field.