Computational Epitranscriptomics Bioinformatic Approaches For The Analysis Of Rna Modifications

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Computational Epitranscriptomics Bioinformatic Approaches For The Analysis Of Rna Modifications

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Author : Mattia Pelizzola
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-02

Computational Epitranscriptomics Bioinformatic Approaches For The Analysis Of Rna Modifications written by Mattia Pelizzola and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-02 with Science categories.

Epitranscriptomics The Novel Rna Frontier

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Author : Giovanni Nigita
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-31

Epitranscriptomics The Novel Rna Frontier written by Giovanni Nigita and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-31 with categories.

Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.

Computational Epigenomics And Epitranscriptomics

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Author : Pedro H. Oliveira
language : en
Publisher: Springer Nature
Release Date : 2023-02-01

Computational Epigenomics And Epitranscriptomics written by Pedro H. Oliveira and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-01 with Science categories.

This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.

Encyclopedia Of Bioinformatics And Computational Biology

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Author :
language : en
Publisher: Elsevier
Release Date : 2018-08-21

Encyclopedia Of Bioinformatics And Computational Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Computational Resources For Understanding Biomacromolecular Covalent Modifications

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Author : Dong Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-14

Computational Resources For Understanding Biomacromolecular Covalent Modifications written by Dong Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-14 with Science categories.

Omics Approaches And Technologies In Covid 19

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Author : Debmalya Barh
language : en
Publisher: Academic Press
Release Date : 2022-12-01

Omics Approaches And Technologies In Covid 19 written by Debmalya Barh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-01 with Medical categories.

The COVID-19 pandemic has affected the entire world in an unprecedented way since 2019. However, novel and innovative applications of various omics, computational, and smart technologies have helped manage the pandemic of the 21st century in a very effective manner. Omics approaches and technologies in COVID-19 presents up-to-date knowledge on omics, genetic engineering, mathematical and computational approaches, and advanced technologies in the diagnosis, prevention, monitoring, and management of COVID-19. This book contains 26 chapters written by academic and industry experts from more than 15 countries. Split into three sections (Omics; Artificial Intelligence and Bioinformatics; and Smart and Emerging Technologies), it brings an overview of novel technologies under omics such as, genomic, metagenomic, pangenomic, metabolomics and proteomics in COVID-19. In addition, it discusses hostpathogen interactions and interactomics, management options, application of genetic engineering, mathematical modeling andsimulations, systems biology, and bioinformatics approaches in COVID-19 drug discovery and vaccine development. This is a valuable resource for students, biotechnologists, bioinformaticians, virologists, clinicians, and pharmaceutical, biomedical, and healthcare industry people who want to understand the promising omics and other technologies used in combating COVID-19 from various aspects. - Provides novel technologies for rapid diagnostics, drug discovery, vaccine development, monitoring, prediction of future waves, etc. - Describes various omics applications including genomics, metagenomics, epigenomics, nutrigenomics, transcriptomics,miRNAomics, proteomics, metabolomics, phenomics, multiomics, etc., in COVID-19 - Presents applications of genetic engineering, CRISPR, artificial intelligence, mathematical and in silico modeling, systems biology,and other computational approaches in COVID-19 - Discusses emerging, digital, and smart technologies for the monitoring and management of COVID-19

Graph Embedding Methods For Multiple Omics Data Analysis

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Author : Chen Qingfeng
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-08

Graph Embedding Methods For Multiple Omics Data Analysis written by Chen Qingfeng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-08 with Science categories.

Handbook Of Statistical Bioinformatics

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Author : Henry Horng-Shing Lu
language : en
Publisher: Springer Nature
Release Date : 2022-12-08

Handbook Of Statistical Bioinformatics written by Henry Horng-Shing Lu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-08 with Science categories.

Now in its second edition, this handbook collects authoritative contributions on modern methods and tools in statistical bioinformatics with a focus on the interface between computational statistics and cutting-edge developments in computational biology. The three parts of the book cover statistical methods for single-cell analysis, network analysis, and systems biology, with contributions by leading experts addressing key topics in probabilistic and statistical modeling and the analysis of massive data sets generated by modern biotechnology. This handbook will serve as a useful reference source for students, researchers and practitioners in statistics, computer science and biological and biomedical research, who are interested in the latest developments in computational statistics as applied to computational biology.

Role Of Rna Modification In Disease

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Author : Emanuele Buratti
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-03

Role Of Rna Modification In Disease written by Emanuele Buratti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with categories.

Microbial Comparative Genomics And Pangenomics New Tools Approaches And Insights Into Gene And Genome Evolution

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Author : Paulo Jorge Dias
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-11

Microbial Comparative Genomics And Pangenomics New Tools Approaches And Insights Into Gene And Genome Evolution written by Paulo Jorge Dias and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-11 with Science categories.

Comparative Genomics is the field of knowledge dedicated to the analysis and comparison of genes and genomes. The scientific areas comprised in this field include subjects as diverse as (just naming a few): 1) the development of algorithms for the alignment of genes, whole genomes, short- and long sequencing reads, 2) the search for remote sequence similarity, 3) the discovery of motifs and sequence patterns, 4) the identification of gene families, 5) the detection of ortholog/paralog groups, 6) the reconstruction of evolutionary history of the genes, 7) the detection of signs of selective forces exerted over genes and genomes, 8) the reconstruction of ancestral DNA and genome sequences, 9) the detection and analysis of genome synteny, 10) the inference of ancestral gene order, among others. In addition, an important new sub-field of Comparative Genomics has emerged in the last decade, referred to as Pangenomics, making available improved tools to analyze the exponential genomic data accumulating since the development of Second- and Third-Generation Sequencing Technologies.