Computational Methods For 3d Genome Analysis
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Computational Methods For 3d Genome Analysis
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Author : Ryuichiro Nakato
language : en
Publisher: Springer Nature
Release Date : 2024-09-16
Computational Methods For 3d Genome Analysis written by Ryuichiro Nakato and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-16 with Science categories.
This volume covers the latest methods and analytical approaches used to study the computational analysis of three-dimensional (3D) genome structure. The chapters in this book are organized into six parts. Part One discusses different NGS assays and the regulatory mechanism of 3D genome folding by SMC complexes. Part Two presents analysis workflows for Hi-C and Micro-C in different species, including human, mouse, medaka, yeast, and prokaryotes. Part Three covers methods for chromatin loop detection, sub-compartment detection, and 3D feature visualization. Part Four explores single-cell Hi-C and the cell-to-cell variability of the dynamic 3D structure. Parts Five talks about the analysis of polymer modelling to simulate the dynamic behavior of the 3D genome structure, and Part Six looks at 3D structure analysis using other omics data, including prediction of 3D genome structure from the epigenome, double-strand break-associated structure, and imaging-based 3D analysis using seqFISH. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Methods for 3D Genome Analysis: Methods and Protocols is a valuable resource for researchers interested in using computational methods to further their studies in the nature of 3D genome organization.
Bioinformatics Methods
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Author : Shili Lin
language : en
Publisher: CRC Press
Release Date : 2022-09-16
Bioinformatics Methods written by Shili Lin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-16 with Mathematics categories.
The past three decades have witnessed an explosion of what is now referred to as high-dimensional `omics' data. Bioinformatics Methods: From Omics to Next Generation Sequencing describes the statistical methods and analytic frameworks that are best equipped to interpret these complex data and how they apply to health-related research. Covering the technologies that generate data, subtleties of various data types, and statistical underpinnings of methods, this book identifies a suite of potential analytic tools, and highlights commonalities among statistical methods that have been developed. An ideal reference for biostatisticians and data analysts that work in collaboration with scientists and clinical investigators looking to ensure rigorous application of available methodologies. Key Features: Survey of a variety of omics data types and their unique features Summary of statistical underpinnings for widely used omics data analysis methods Description of software resources for performing omics data analyses
Computational Methods In Molecular Biology
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Author : S.L. Salzberg
language : en
Publisher: Elsevier
Release Date : 1998-06-19
Computational Methods In Molecular Biology written by S.L. Salzberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-19 with Science categories.
Computational biology is a rapidly expanding field, and the number and variety of computational methods used for DNA and protein sequence analysis is growing every day. These algorithms are extremely valuable to biotechnology companies and to researchers and teachers in universities.This book explains the latest computer technology for analyzing DNA, RNA, and protein sequences. Clear and easy to follow, designed specifically for the non-computer scientist, it will help biologists make better choices on which algorithm to use. New techniques and demonstrations are elucidated, as are state-of-the-art problems, and more advanced material on the latest algorithms.The primary audience for this volume are molecular biologists working either in biotechnology companies or academic research environments, individual researchers and the institutions they work for, and students. Any biologist who relies on computers should want this book.A secondary audience will be computer scientists developing techniques with applications in biology.An excellent reference for leading techniques, it will also help introduce computer scientists to the biology problems. This is an outstanding work which will be ideal for the increasing number of scientists moving into computational biology.
Computational Methods In Molecular Biology
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-07-09
Computational Methods In Molecular Biology written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-09 with Science categories.
EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels.
Gene Regulation And Epigenetics
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Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2024-10-04
Gene Regulation And Epigenetics written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-04 with Science categories.
This book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix “epi” (meaning “upon,” “above,” or “beyond”) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 μm. This protein-DNA complex is known as chromatin. The content of this book is linked to the “Molecular Medicine and Genetics” course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks “Mechanisms of Gene Regulation” and “Human Epigenomics.” It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms.
Research In Computational Molecular Biology
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Author : Itsik Pe'er
language : en
Publisher: Springer Nature
Release Date : 2022-05-11
Research In Computational Molecular Biology written by Itsik Pe'er and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-11 with Computers categories.
This book constitutes the proceedings of the 26th Annual Conference on Research in Computational Molecular Biology, RECOMB 2022, held in San Diego, CA, USA in May 2022. The 17 regular and 23 short papers presented were carefully reviewed and selected from 188 submissions. The papers report on original research in all areas of computational molecular biology and bioinformatics.
Bibliography Of Agriculture With Subject Index
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Author :
language : en
Publisher:
Release Date : 1993-05
Bibliography Of Agriculture With Subject Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-05 with Agriculture categories.
Management For Scientists
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Author : Robert B. Mellor
language : en
Publisher: Emerald Group Publishing
Release Date : 2019-03-19
Management For Scientists written by Robert B. Mellor and has been published by Emerald Group Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-19 with Business & Economics categories.
Management for Scientists explores the core theories and practices in management studies today in a context applicable to those working in the scientific industries. Chapters feature a range of real-world examples presented by experienced scientists with strategic and economic business expertise.
Genome Analysis And Human Health
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Author : Leena Rawal
language : en
Publisher: Springer
Release Date : 2017-06-08
Genome Analysis And Human Health written by Leena Rawal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-08 with Medical categories.
This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.
Challenges In Delivery Of Therapeutic Genomics And Proteomics
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Author : Aliasgar Shahiwala
language : en
Publisher: Academic Press
Release Date : 2025-03-06
Challenges In Delivery Of Therapeutic Genomics And Proteomics written by Aliasgar Shahiwala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-06 with Medical categories.
Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented. - Includes genomics and proteomics delivery in one single volume - Highlights what's currently known and where further research is necessary - Covers topics from academic and corporate R&D perspectives - Includes new chapters on regulation, CRISPR/Cas9, and computational tools