Computational Methods For Genetics Of Complex Traits
DOWNLOAD
Download Computational Methods For Genetics Of Complex Traits PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Computational Methods For Genetics Of Complex Traits book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Computational Methods For Genetics Of Complex Traits
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2010-11-10
Computational Methods For Genetics Of Complex Traits written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-10 with Science categories.
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics reasearch. This thematic volume of Advances in Genetics looks at Computational Methods for Genetics of Complex traits. - Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models - Includes methods for testing with ethical, legal, and social implications - Critically analyzes future prospects
Molecular Dissection Of Complex Traits
DOWNLOAD
Author : Andrew H. Paterson
language : en
Publisher: CRC Press
Release Date : 2019-09-17
Molecular Dissection Of Complex Traits written by Andrew H. Paterson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-17 with Science categories.
In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Computational Methods For Disease Diagnosis And Understanding The Genetics Of Complex Traits
DOWNLOAD
Author : Lisa Gai
language : en
Publisher:
Release Date : 2021
Computational Methods For Disease Diagnosis And Understanding The Genetics Of Complex Traits written by Lisa Gai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
An ever increasing wealth of biological data has become available in recent years, and with it, the potential to understand complex traits and extract disease relevant information from these many forms of data through computational methods. Understanding the genetic architecture behind complex traits can help us understand disease risk and adverse drug reactions, and to guide the development of treatment strategies. Many variants identified by genome-wide association studies (GWAS) have been found to affect multiple traits, either directly or through shared pathways. Analyzing multiple traits at once can increase power to detect shared variant effects from publicly available GWAS summary statistics. Use of multiple traits may also improve accuracy when estimating variant effects, which can be used in polygenic scores to stratify individuals by disease risk. This dissertation presents a method, CONFIT, for combining GWAS in multiple traits for variant discovery, and explores a few potential multi-trait methods for estimating polygenic scores. Computational methods can also be used to identify patients already suffering from disease who would benefit from treatment. Towards this end, this dissertation also presents work on deep learning to detect patients with orbital disease from image data with high accuracy and recall.
Computational Methods For Understanding Complexity The Use Of Formal Methods In Biology
DOWNLOAD
Author : David A. Rosenblueth,
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-21
Computational Methods For Understanding Complexity The Use Of Formal Methods In Biology written by David A. Rosenblueth, and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with categories.
The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.
Computational Genetics And Genomics
DOWNLOAD
Author : Gary Peltz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-05
Computational Genetics And Genomics written by Gary Peltz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-05 with Medical categories.
Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial.
Genetics And Analysis Of Quantitative Traits
DOWNLOAD
Author : Michael Lynch
language : en
Publisher: Sinauer Associates Incorporated
Release Date : 1998-01
Genetics And Analysis Of Quantitative Traits written by Michael Lynch and has been published by Sinauer Associates Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01 with Science categories.
Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
Genetic Dissection Of Complex Traits
DOWNLOAD
Author : D.C. Rao
language : en
Publisher: Academic Press
Release Date : 2008-04-23
Genetic Dissection Of Complex Traits written by D.C. Rao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-23 with Medical categories.
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Human Genome Epidemiology 2nd Edition
DOWNLOAD
Author : Muin J. Khoury
language : en
Publisher: Oxford University Press
Release Date : 2010-01-20
Human Genome Epidemiology 2nd Edition written by Muin J. Khoury and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-20 with Medical categories.
The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace.With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.
Practical Applications Of Computational Biology Bioinformatics 15th International Conference Pacbb 2021
DOWNLOAD
Author : Miguel Rocha
language : en
Publisher: Springer Nature
Release Date : 2021-08-27
Practical Applications Of Computational Biology Bioinformatics 15th International Conference Pacbb 2021 written by Miguel Rocha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Technology & Engineering categories.
This book features novel research papers spanning many different subfields in bioinformatics and computational biology, presenting the latest research on the practical applications to promote fruitful interactions between young researchers in different areas related to the field. Clearly, biology is increasingly becoming a science of information, requiring tools from the computational sciences. To address these challenges, we have seen the emergence of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. PACBB'21 expects to contribute to this effort by encouraging a successful collaboration of researchers in different areas related to bioinformatics. The PACBB'21 technical program included 17 papers covering many different subfields in bioinformatics and computational biology. Therefore, this conference, held in Salamanca (Spain), definitely promotes the collaboration of scientists from different research groups and with different backgrounds (computer scientists, mathematicians, biologists) to reach breakthrough solutions for these challenges.
Biostatistical Methods In Genetics And Genetic Epidemiology An Introduction To Genetic Epidemiology Biostatistical Genetics
DOWNLOAD
Author : Lynn Decollblanc
language : en
Publisher: Lynn Decollblanc
Release Date : 2023-06-19
Biostatistical Methods In Genetics And Genetic Epidemiology An Introduction To Genetic Epidemiology Biostatistical Genetics written by Lynn Decollblanc and has been published by Lynn Decollblanc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-19 with Medical categories.
Biostatistical Methods in Genetics and Genetic Epidemiology offers a comprehensive exploration of the powerful intersection between biostatistics, genetics, and epidemiology. This authoritative book delves into the fundamental principles and advanced methodologies that drive genetic research and enable a deeper understanding of the complex relationship between genes, diseases, and population health. With a focus on practical applications and real-world examples, this book equips readers with the necessary tools to navigate the vast landscape of genomic analysis. From unraveling genetic variation to investigating disease risk factors and exploring the role of environmental factors, this book provides a solid foundation for researchers, practitioners, and students in the fields of biostatistics, genetics, epidemiology, and related disciplines. Key Features: Comprehensive Coverage: Explore the essential concepts, techniques, and study designs used in genetic research, including case-control studies, linkage analysis, genome-wide association studies, and more. Statistical Methods: Gain a deep understanding of the statistical principles and methodologies employed in genetic analysis, including statistical genetics, genetic risk prediction, and analysis of complex traits. Genetic Epidemiology: Examine the integration of genetics and epidemiology, uncovering how genetic factors interact with environmental and lifestyle factors to influence disease outcomes and population health. Practical Examples: Benefit from real-world examples and case studies that demonstrate the application of biostatistical methods in unraveling the genetic underpinnings of diseases, identifying genetic risk factors, and informing public health interventions. Ethical and Legal Considerations: Explore the ethical implications and challenges surrounding genetic research, genetic counseling, privacy, and data sharing. Emerging Trends: Stay up-to-date with the latest advancements in the field, including precision medicine, pharmacogenomics, epigenetics, and the integration of multi-omics data. Biostatistical Methods in Genetics and Genetic Epidemiology is an invaluable resource for researchers, practitioners, and students seeking to unravel the complexities of genetics and its impact on human health. Whether you are a biostatistician, geneticist, epidemiologist, or medical professional, this book will empower you to navigate the rapidly evolving field of genomics and make meaningful contributions to precision medicine, disease prevention, and public health initiatives.