Genetic Dissection Of Complex Traits
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Genetic Dissection Of Complex Traits
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Author : Dabeeru C. Rao
language : en
Publisher:
Release Date : 2001
Genetic Dissection Of Complex Traits written by Dabeeru C. Rao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Gene mapping categories.
Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants
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Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.
The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits
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Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2019-06-19
The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with categories.
Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.
Molecular Dissection Of Complex Traits
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Author : Andrew H. Paterson
language : en
Publisher: CRC Press
Release Date : 2019-09-17
Molecular Dissection Of Complex Traits written by Andrew H. Paterson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-17 with Science categories.
In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
An Integrated Approach For The Genetic Dissection Of Complex Traits In Yeast
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Author : Gal-Hagit Romano
language : en
Publisher:
Release Date : 2009
An Integrated Approach For The Genetic Dissection Of Complex Traits In Yeast written by Gal-Hagit Romano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Genetic Dissection Of Complex Traits
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Author : D.C. Rao
language : en
Publisher: Academic Press
Release Date : 2008-04-23
Genetic Dissection Of Complex Traits written by D.C. Rao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-23 with Science categories.
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Five sections on the latest advances in complex traits * Methods for testing with ethical, legal, and social implications * Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
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Author : Sagiv Shifman
language : en
Publisher:
Release Date : 2004
written by Sagiv Shifman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Bioinformatics Tools For The Genetic Dissection Of Complex Traits In Chickens
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Author : Claudia Paola Cabrera Cárdenas
language : en
Publisher:
Release Date : 2009
Bioinformatics Tools For The Genetic Dissection Of Complex Traits In Chickens written by Claudia Paola Cabrera Cárdenas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
This thesis explores the genetic characterization of the mechanisms underlying complex traits in chicken through the use and development of bioinformatics tools. The characterization of quantitative trait loci controlling complex traits has proven to be very challenging. This thesis comprises the study of experimental designs, annotation procedures and functional analyses. These represent some of the main 'bottlenecks' involved in the integration of QTLs with the biological interpretation of high-throughput technologies. The thesis begins with an investigation of the bioinformatics tools and procedures available for genome research, briefly reviewing microarray technology and commonly applied experimental designs. A targeted experimental design based on the concept of genetical genomics is then presented and applied in order to study a known functional QTL responsible for chicken body weight. This approach contrasts the gene expression levels of two alternative QTL genotypes, hence narrowing the QTL-phenotype gap, and, giving a direct quantification of the link between the genotypes and the genetic responses. Potential candidate genes responsible for the chicken body weight QTL are identified by using the location of the genes, their expression and biological significance. In order to deal with the multiple sources of information and exploit the data effectively, a systematic approach and a relational database were developed to improve the annotation of the probes of the ARK-Genomics G. gallus 13K v4.0 cDNA array utilized on the experiment. To follow up the investigation of the targeted genetical genomics study, a detailed functional analysis is performed on the dataset. The aim is to identify the downstream effects through the identification of functional variation found in pathways, and secondly to achieve a further characterization of potential candidate genes by using comparative genomics and sequence analyses. Finally the investigation of the body weight QTL syntenic regions and their reported QTLs are presented.
Oryza From Molecule To Plant
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Author : Takuji Sasaki
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Oryza From Molecule To Plant written by Takuji Sasaki and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Recent studies have shown that despite gross differences in genome size, the gene order in the cereal genomes has remained remarkably similar. This observation implies that the small genome of rice will reflect the basic structure of the cereal genomes. Rice will therefore become an important tool for all cereal geneticists/molecular biologists as information generated by rice breeders/geneticists/molecular biologists becomes combined in databases with that generated by researchers studying other cereals. Rice research will therefore be of interest to all cereal breeders/geneticists/molecular biologists. This Edition reviews the current state of knowledge of its genome, genes, germplasm collections, trait analysis, breeding systems, mutator systems, transformation and diseases.
Molecular Genetic Dissection Of Complex Immunocompetence Traits In Broilers
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Author : United States-Israel Binational Agricultural Research and Development Fund
language : en
Publisher:
Release Date : 2003
Molecular Genetic Dissection Of Complex Immunocompetence Traits In Broilers written by United States-Israel Binational Agricultural Research and Development Fund and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.