Genetic Dissection Of Complex Traits

DOWNLOAD

Download Genetic Dissection Of Complex Traits PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Genetic Dissection Of Complex Traits book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Genetic Dissection Of Complex Traits

DOWNLOAD
Author : D.C. Rao
language : en
Publisher: Academic Press
Release Date : 2008-04-23

Genetic Dissection Of Complex Traits written by D.C. Rao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-23 with Medical categories.

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more

Molecular Dissection Of Complex Traits

DOWNLOAD
Author : Andrew H. Paterson
language : en
Publisher: CRC Press
Release Date : 2019-09-17

Molecular Dissection Of Complex Traits written by Andrew H. Paterson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-17 with Science categories.

In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi

Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants

DOWNLOAD
Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26

Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.

Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.

The Genetic Dissection Of Complex Traits

DOWNLOAD
Author : Christy Myrick
language : en
Publisher:
Release Date : 1998

The Genetic Dissection Of Complex Traits written by Christy Myrick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.

The Oil Palm Genome

DOWNLOAD
Author : Maizura Ithnin
language : en
Publisher: Springer Nature
Release Date : 2020-06-12

The Oil Palm Genome written by Maizura Ithnin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-12 with Science categories.

This book compiles the fundamental advances resulting from of oil-palm genome and transcriptome sequencing, and describes the challenges faced and strategies applied in sequencing, assembling and annotating oil palm genome sequences. The availability of genome and transcriptome data has made the mining of a high number of new molecular markers useful for genetic diversity as well as marker-trait association studies and the book presents high-throughput genotyping platforms, which allow the detection of QTL regions associated with interesting oil palm traits such as oil unsaturation and yield components using classical genetic and association mapping approaches. Lastly, it also presents the discovery of major genes governing economically important traits of the oil palm. Covering the history of oil palm expansion, classical and molecular cytogenetics, improvements based on wild and advanced genetic materials, and the science of oil palm breeding, the book is a valuable resource for scientists involved in plant genetic research.

Genetic Dissection Of Complex Traits

DOWNLOAD
Author : Pankaj Sharma
language : en
Publisher:
Release Date : 1998

Genetic Dissection Of Complex Traits written by Pankaj Sharma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.

Aquatic Genomics

DOWNLOAD
Author : N. Shimizu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Aquatic Genomics written by N. Shimizu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.

In a scientific pursuit there is continual food for discovery and wonder. M. Shelley (1818) Genomic analysis of aquatic species has long been overshadowed by the superb activity of the human genome project. However, aquatic genomics is now in the limelight as evidenced by the recent accomplishment of fugu genome sequencing, which provided a significant foundation for comparative fish genomics. Undoubt edly, such progress will provide an exciting and unparalleled boost to our knowl edge of the genetics of aquatic species. Thus, aquatic genomics research has become a promising new research field with an impact on the fishery industry. It is notewor thy that the Food and Agriculture Organization (FAO) of the United Nations has projected that current global fisheries production will soon become insufficient to supply the increasing world population and that aquaculture has a great potential to fulfill that demand. This book, Aquatic Genomic. ~: Steps Toward a Great Future, was designedas a collection of advanced knowledge in aquatic genomics and biological sciences. It covers a variety of aquatic organisms including fish, crustaceans, and shellfish, and describes various advanced methodologies, including genome analysis, gene map ping, DNA markers, and EST analysis. Also included are discussions of many sub jects such as regulation of gene expression, stress and immune responses, sex differ entiation, hormonal control, and transgenic fishes.

The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits

DOWNLOAD
Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2019-06-19

The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with categories.

Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.

Genetic Dissection Of Important Traits In Aquaculture Genome Scale Tools Development Trait Localization And Regulatory Mechanism Exploration

DOWNLOAD
Author : Peng Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-31

Genetic Dissection Of Important Traits In Aquaculture Genome Scale Tools Development Trait Localization And Regulatory Mechanism Exploration written by Peng Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with categories.

Making Sense Of Genes

DOWNLOAD
Author : Kostas Kampourakis
language : en
Publisher: Cambridge University Press
Release Date : 2017-03-30

Making Sense Of Genes written by Kostas Kampourakis and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-30 with Science categories.

What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.