Computational Methods In Cardiac Electrophysiology

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Computational Methods In Cardiac Electrophysiology

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Author : Matthijs Cluitmans
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-06

Computational Methods In Cardiac Electrophysiology written by Matthijs Cluitmans and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Science categories.

Mathematical Cardiac Electrophysiology

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Author : Piero Colli Franzone
language : en
Publisher: Springer
Release Date : 2014-10-30

Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-30 with Mathematics categories.

This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

Computational And Mathematical Methods In Cardiovascular Physiology

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Author : Liang Zhong
language : en
Publisher: World Scientific
Release Date : 2019-04-26

Computational And Mathematical Methods In Cardiovascular Physiology written by Liang Zhong and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-26 with Medical categories.

Cardiovascular diseases (CVD) including heart diseases, peripheral vascular disease and heart failure, account for one-third of deaths throughout the world. CVD risk factors include systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and diabetic status. Clinical trials have demonstrated that when modifiable risk factors are treated and corrected, the chances of CVD occurring can be reduced. This illustrates the importance of this book's elaborate coverage of cardiovascular physiology by the application of mathematical and computational methods.This book has literally transformed Cardiovascular Physiology into a STEM discipline, involving (i) quantitative formulations of heart anatomy and physiology, (ii) technologies for imaging the heart and blood vessels, (iii) coronary stenosis hemodynamics measure by means of fractional flow reserve and intervention by grafting and stenting, (iv) fluid mechanics and computational analysis of blood flow in the heart, aorta and coronary arteries, and (v) design of heart valves, percutaneous valve stents, and ventricular assist devices.So how is this mathematically and computationally configured landscape going to impact cardiology and even cardiac surgery? We are now entering a new era of mathematical formulations of anatomy and physiology, leading to technological formulations of medical and surgical procedures towards more precise medicine and surgery. This will entail reformatting of (i) the medical MD curriculum and courses, so as to educate and train a new generation of physicians who are conversant with medical technologies for applying into clinical care, as well as (ii) structuring of MD-PhD (Computational Medicine and Surgery) Program, to train competent medical and surgical specialists in precision medical care and patient-specific surgical care.This book provides a gateway for this new emerging scenario of (i) science and engineering based medical educational curriculum, and (ii) technologically oriented medical and surgical procedures. As such, this book can be usefully employed as a textbook for courses in (i) cardiovascular physiology in both the schools of engineering and medicine of universities, as well as (ii) cardiovascular engineering in biomedical engineering departments worldwide.

Cardiac Electrophysiology Methods And Models

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Author : Daniel C. Sigg
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-11

Cardiac Electrophysiology Methods And Models written by Daniel C. Sigg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-11 with Medical categories.

Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Computational Methods In Systems Biology

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Author : Jun Pang
language : en
Publisher: Springer Nature
Release Date : 2023-09-08

Computational Methods In Systems Biology written by Jun Pang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-08 with Science categories.

This book constitutes the refereed proceedings of the 21st International Conference on Computational Methods in Systems Biology, CMSB 2023, held in Luxembourg City, Luxembourg, during September 13–15, 2023. The 14 full papers and 3 tool papers presented in this book were carefully reviewed and selected from 28 submissions. CMSB focuses on modeling, simulation, analysis, design and control of biological systems and covers the broad field of computational methods and tools in systems and synthetic biology and their applications.

Exploring Mechanisms Of Cardiac Rhythm Disturbances Using Novel Computational Methods Prediction Classification And Therapy

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Author : Xin Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-16

Exploring Mechanisms Of Cardiac Rhythm Disturbances Using Novel Computational Methods Prediction Classification And Therapy written by Xin Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Science categories.

Computational Cardiology

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Author : Frank B. Sachse
language : en
Publisher: Springer
Release Date : 2005-01-12

Computational Cardiology written by Frank B. Sachse and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-12 with Medical categories.

This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.

Computational Methods For The Atmosphere And The Oceans

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Author : Roger Temam
language : en
Publisher: Elsevier
Release Date : 2009-06-16

Computational Methods For The Atmosphere And The Oceans written by Roger Temam and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-16 with Computers categories.

This book provides a survey of the frontiers of research in the numerical modeling and mathematical analysis used in the study of the atmosphere and oceans. The details of the current practices in global atmospheric and ocean models, the assimilation of observational data into such models and the numerical techniques used in theoretical analysis of the atmosphere and ocean are among the topics covered.• Truly interdisciplinary: scientific interactions between specialties of atmospheric and ocean sciences and applied and computational mathematics • Uses the approach of computational mathematicians, applied and numerical analysts and the tools appropriate for unsolved problems in the atmospheric and oceanic sciences• Contributions uniquely address central problems and provide a survey of the frontier of research

Computing The Electrical Activity In The Heart

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Author : Joakim Sundnes
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-26

Computing The Electrical Activity In The Heart written by Joakim Sundnes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-26 with Mathematics categories.

The heart is a fantastic machine; during a normal lifetime it beats about 2.5 billion times and pumps 200.000 tons of blood through an enormous system of vessels extending 160.000 kilometres throughout the body. For centuries, man has tried to understand how the heart works, but there remain many unsolved problems, problems that have captured the attention of thousands of researchers worldwide. There is, for example, a huge amount of research being devoted to the analysis of single heart cells. Other areas of research include trying to understand how it works as a complete muscle, and how blood ows through the heart. The entire process is extremely complex. The history of bioelectricity can be traced back to the late eighteenth century and the experiments of Luigi Galvani. A century later, in 1887, Augustus Wallers managed to measure the electrical signal generated by the heart at the surface of the body [142]. His dog Jimmy earned a place in history by being the rst to have his heart measured in this way; see Figure 1.1. In 1903 Willem Einthoven [34] - veloped the rst commercial device for recording electrocardiograms (ECGs); see Figure 1.2.

Artificial Intelligence For Computational Modeling Of The Heart

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Author : Tommaso Mansi
language : en
Publisher: Academic Press
Release Date : 2019-11-25

Artificial Intelligence For Computational Modeling Of The Heart written by Tommaso Mansi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with Science categories.

Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. - Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications - Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data - Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation