Cardiac Electrophysiology Methods And Models
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Cardiac Electrophysiology Methods And Models
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Author : Daniel C. Sigg
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-11
Cardiac Electrophysiology Methods And Models written by Daniel C. Sigg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-11 with Medical categories.
Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.
Cardiac Electrophysiology Methods And Models
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Author : Paul A. Iaizzo
language : en
Publisher: Springer Nature
Release Date : 2024-12-24
Cardiac Electrophysiology Methods And Models written by Paul A. Iaizzo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Medical categories.
Cardiovascular disease is the major cause of mortality and morbidity around the world. While significant progress has been made in treating a major sub-category of cardiac disease and arrhythmias, significant unmet needs remain. Every day, thousands of patients die due to arrhythmias in the U.S. alone, and atrial fibrillation is the most common arrhythmia that affects millions of Americans at any given time. Therefore, there is an urgent public need to continue to develop new and better therapies for arrhythmias. This book reviews key research methods and protocols in cardiac electrophysiology with a focus on advantages and pitfalls. It will discuss new developments as well as traditional treatments and methods. Chapters will focus on practical implementation and collaborative cross-functional research methods. The book will contain contributions from scientists and clinicians from various academic and industrial research institutions. The inclusion of industrial experts expands the scope and potential audience of this book, and provides important perspective beyond basic science. Contributors will include researchers and clinicians from academic institutions such as the University of Minnesota, Harvard, Washington University, Case Western, Indiana University, and Manchester University. Methods and Models in Cardiac Electrophysiology will be a must-have resource for clinical academic scientists, engineers from industry (Biotech, Pharma, and Medical Device), undergraduate and graduate students, physicians, biomedical engineers, and high school and college teachers interested in studying cardiac electrophysiology and cardiac function. The book may also be of interest to students in the fields of physiology, molecular biology, cellular biology, biomedical engineering, mechanical engineering, electrical engineering, and related areas.
Mathematical Cardiac Electrophysiology
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Author : Piero Colli Franzone
language : en
Publisher: Springer
Release Date : 2014-10-30
Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-30 with Mathematics categories.
This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.
Advanced Hpc Based Computational Modeling In Biomechanics And Systems Biology
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Author : Mariano Vázquez
language : en
Publisher: Frontiers Media SA
Release Date : 2019-04-04
Advanced Hpc Based Computational Modeling In Biomechanics And Systems Biology written by Mariano Vázquez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-04 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Computational Methods In Cardiac Electrophysiology
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Author : Matthijs Cluitmans
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-06
Computational Methods In Cardiac Electrophysiology written by Matthijs Cluitmans and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Science categories.
Zipes And Jalife S Cardiac Electrophysiology From Cell To Bedside E Book
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Author : Jose Jalife
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-12-16
Zipes And Jalife S Cardiac Electrophysiology From Cell To Bedside E Book written by Jose Jalife and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-16 with Medical categories.
Fully updated from cover to cover, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. - Packs each chapter with the latest information necessary for optimal basic research as well as patient care. - Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. - Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. - Includes 47 new chapters covering both basic science and clinical topics. - Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. - Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. - Recipient of a 2018 Highly Commended award from the British Medical Association. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Experimental Models And Model Organisms In Cardiac Electrophysiology Opportunities And Challenges
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Author : Ruben Coronel
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-05
Experimental Models And Model Organisms In Cardiac Electrophysiology Opportunities And Challenges written by Ruben Coronel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-05 with Science categories.
Patient Specific Modeling Of The Cardiovascular System
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Author : Roy C.P. Kerckhoffs
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-03
Patient Specific Modeling Of The Cardiovascular System written by Roy C.P. Kerckhoffs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-03 with Science categories.
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Artificial Intelligence In Heart Modelling
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Author : Rafael Sebastian
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-11
Artificial Intelligence In Heart Modelling written by Rafael Sebastian and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-11 with Science categories.
Artificial Intelligence For Computational Modeling Of The Heart
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Author : Tommaso Mansi
language : en
Publisher: Academic Press
Release Date : 2019-11-25
Artificial Intelligence For Computational Modeling Of The Heart written by Tommaso Mansi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with Science categories.
Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. - Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications - Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data - Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation