Computational Modeling In Tissue Engineering
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Computational Modeling In Tissue Engineering
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Author : Liesbet Geris
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-30
Computational Modeling In Tissue Engineering written by Liesbet Geris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-30 with Technology & Engineering categories.
One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.
Advances On Modeling In Tissue Engineering
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Author : Paulo R. Fernandes
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-21
Advances On Modeling In Tissue Engineering written by Paulo R. Fernandes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-21 with Computers categories.
This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.
Modelling Organs Tissues Cells And Devices
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Author : Socrates Dokos
language : en
Publisher: Springer
Release Date : 2017-03-08
Modelling Organs Tissues Cells And Devices written by Socrates Dokos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-08 with Technology & Engineering categories.
This book presents a theoretical and practical overview of computational modeling in bioengineering, focusing on a range of applications including electrical stimulation of neural and cardiac tissue, implantable drug delivery, cancer therapy, biomechanics, cardiovascular dynamics, as well as fluid-structure interaction for modelling of organs, tissues, cells and devices. It covers the basic principles of modeling and simulation with ordinary and partial differential equations using MATLAB and COMSOL Multiphysics numerical software. The target audience primarily comprises postgraduate students and researchers, but the book may also be beneficial for practitioners in the medical device industry.
Computational Modeling In Biomedical Engineering And Medical Physics
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Author : Alexandru Morega
language : en
Publisher: Academic Press
Release Date : 2020-09-18
Computational Modeling In Biomedical Engineering And Medical Physics written by Alexandru Morega and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-18 with Science categories.
Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies.
Advances On Modeling In Tissue Engineering
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Author : Paulo Rui Fernandes
language : en
Publisher: Springer
Release Date : 2011-05-22
Advances On Modeling In Tissue Engineering written by Paulo Rui Fernandes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-22 with Computers categories.
This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.
Tissue Engineering
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Author : Paulo Rui Fernandes
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-31
Tissue Engineering written by Paulo Rui Fernandes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-31 with Technology & Engineering categories.
This book describes the state of the art on computational modeling and fabrication in Tissue Engineering. It is inspired by the ECCOMAS thematic conference, the European Committee on Computational Methods in Applied Sciences, on Tissue Engineering, held in Lisbon, Portugal, June 2-4, 2011. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. Emphasis is put on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.
Uncertainty In Biology
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Author : Liesbet Geris
language : en
Publisher: Springer
Release Date : 2015-11-11
Uncertainty In Biology written by Liesbet Geris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-11 with Technology & Engineering categories.
Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Advances In Ceramic Biomaterials
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Author : Paola Palmero
language : en
Publisher: Woodhead Publishing
Release Date : 2017-09-15
Advances In Ceramic Biomaterials written by Paola Palmero and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-15 with Technology & Engineering categories.
Bioceramics are an important class of biomaterials. Due to their desirable attributes such as biocompatibility and osseointegration, as well as their similarity in structure to bone and teeth, ceramic biomaterials have been successfully used in hard tissue applications. In this book, a team of materials research scientists, engineers, and clinicians bridge the gap between materials science and clinical commercialization providing integrated coverage of bioceramics, their applications and challenges. The book is divided into three parts. The first part is a review of classes of medical-grade ceramic materials, their synthesis and processing as well as methods of property assessment. The second part contains a review of ceramic medical products and devices developed, their evolution, their clinical applications and some of the lessons learned from decades of clinical use. The third part outlines the challenges to improve performance and the directions that novel approaches and advanced technologies are taking, to meet these challenges. With a focus on the dialogue between surgeons, engineers, material scientists, and biologists, this book is a valuable resource for researchers and engineers working toward long-lasting, reliable, customized biomedical ceramic and composites devices. - Edited by a team of experts with expertise in industry and academia - Compiles the most relevant aspects on regulatory issues, standards and engineering of bioceramic medical devices as inspired by commercial and clinical needs - Introduces bioceramics, their evolution and applications in hard tissue engineering and medical devices
Principles Of Tissue Engineering
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Author : Robert Lanza
language : en
Publisher: Elsevier
Release Date : 2000-05-16
Principles Of Tissue Engineering written by Robert Lanza and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-16 with Science categories.
The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others
Tissue Engineered Vascular Grafts
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Author : Beat H. Walpoth
language : en
Publisher: Springer
Release Date : 2020-08-21
Tissue Engineered Vascular Grafts written by Beat H. Walpoth and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-21 with Science categories.
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.