Computing Characterizations Of Drugs For Ion Channels And Receptors Using Markov Models
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Computing Characterizations Of Drugs For Ion Channels And Receptors Using Markov Models
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Author : Aslak Tveito
language : en
Publisher: Springer
Release Date : 2016-04-19
Computing Characterizations Of Drugs For Ion Channels And Receptors Using Markov Models written by Aslak Tveito and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Computers categories.
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.
Perspectives On Antiarrhythmic Drug Therapy Disappointing Past Current Efforts And Faint Hopes
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Author : Peter P. Nanasi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-09-08
Perspectives On Antiarrhythmic Drug Therapy Disappointing Past Current Efforts And Faint Hopes written by Peter P. Nanasi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-08 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Scientific Computing
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Author : John A. Trangenstein
language : en
Publisher: Springer
Release Date : 2018-05-14
Scientific Computing written by John A. Trangenstein and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-14 with Mathematics categories.
This is the second of three volumes providing a comprehensive presentation of the fundamentals of scientific computing. This volume discusses more advanced topics than volume one, and is largely not a prerequisite for volume three. This book and its companions show how to determine the quality of computational results, and how to measure the relative efficiency of competing methods. Readers learn how to determine the maximum attainable accuracy of algorithms, and how to select the best method for computing problems. This book also discusses programming in several languages, including C++, Fortran and MATLAB. There are 49 examples, 110 exercises, 66 algorithms, 24 interactive JavaScript programs, 77 references to software programs and 1 case study. Topics are introduced with goals, literature references and links to public software. There are descriptions of the current algorithms in LAPACK, GSLIB and MATLAB. This book could be used for a second course in numerical methods, for either upper level undergraduates or first year graduate students. Parts of the text could be used for specialized courses, such as nonlinear optimization or iterative linear algebra.
Finite Difference Computing With Pdes
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Author : Hans Petter Langtangen
language : en
Publisher: Springer
Release Date : 2017-06-21
Finite Difference Computing With Pdes written by Hans Petter Langtangen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-21 with Computers categories.
This book is open access under a CC BY 4.0 license. This easy-to-read book introduces the basics of solving partial differential equations by means of finite difference methods. Unlike many of the traditional academic works on the topic, this book was written for practitioners. Accordingly, it especially addresses: the construction of finite difference schemes, formulation and implementation of algorithms, verification of implementations, analyses of physical behavior as implied by the numerical solutions, and how to apply the methods and software to solve problems in the fields of physics and biology.
Scientific Computing
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Author : Bertil Gustafsson
language : en
Publisher: Springer
Release Date : 2018-10-03
Scientific Computing written by Bertil Gustafsson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-03 with Mathematics categories.
This book explores the most significant computational methods and the history of their development. It begins with the earliest mathematical / numerical achievements made by the Babylonians and the Greeks, followed by the period beginning in the 16th century. For several centuries the main scientific challenge concerned the mechanics of planetary dynamics, and the book describes the basic numerical methods of that time. In turn, at the end of the Second World War scientific computing took a giant step forward with the advent of electronic computers, which greatly accelerated the development of numerical methods. As a result, scientific computing became established as a third scientific method in addition to the two traditional branches: theory and experimentation. The book traces numerical methods’ journey back to their origins and to the people who invented them, while also briefly examining the development of electronic computers over the years. Featuring 163 references and more than 100 figures, many of them portraits or photos of key historical figures, the book provides a unique historical perspective on the general field of scientific computing – making it a valuable resource for all students and professionals interested in the history of numerical analysis and computing, and for a broader readership alike.
Multiscale Models In Mechano And Tumor Biology
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Author : Alf Gerisch
language : en
Publisher: Springer
Release Date : 2018-03-16
Multiscale Models In Mechano And Tumor Biology written by Alf Gerisch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-16 with Mathematics categories.
This book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.
Numerical Geometry Grid Generation And Scientific Computing
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Author : Vladimir A. Garanzha
language : en
Publisher: Springer Nature
Release Date : 2021-09-25
Numerical Geometry Grid Generation And Scientific Computing written by Vladimir A. Garanzha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-25 with Mathematics categories.
The focus of these conference proceedings is on research, development, and applications in the fields of numerical geometry, scientific computing and numerical simulation, particularly in mesh generation and related problems. In addition, this year’s special focus is on Delaunay triangulations and their applications, celebrating the 130th birthday of Boris Delaunay. In terms of content, the book strikes a balance between engineering algorithms and mathematical foundations. It presents an overview of recent advances in numerical geometry, grid generation and adaptation in terms of mathematical foundations, algorithm and software development and applications. The specific topics covered include: quasi-conformal and quasi-isometric mappings, hyperelastic deformations, multidimensional generalisations of the equidistribution principle, discrete differential geometry, spatial and metric encodings, Voronoi-Delaunay theory for tilings and partitions, duality in mathematical programming and numerical geometry, mesh-based optimisation and optimal control methods. Further aspects examined include iterative solvers for variational problems and algorithm and software development. The applications of the methods discussed are multidisciplinary and include problems from mathematics, physics, biology, chemistry, material science, and engineering.
Software For Exascale Computing Sppexa 2016 2019
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Author : Hans-Joachim Bungartz
language : en
Publisher: Springer Nature
Release Date : 2020-07-30
Software For Exascale Computing Sppexa 2016 2019 written by Hans-Joachim Bungartz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-30 with Computers categories.
This open access book summarizes the research done and results obtained in the second funding phase of the Priority Program 1648 "Software for Exascale Computing" (SPPEXA) of the German Research Foundation (DFG) presented at the SPPEXA Symposium in Dresden during October 21-23, 2019. In that respect, it both represents a continuation of Vol. 113 in Springer’s series Lecture Notes in Computational Science and Engineering, the corresponding report of SPPEXA’s first funding phase, and provides an overview of SPPEXA’s contributions towards exascale computing in today's sumpercomputer technology. The individual chapters address one or more of the research directions (1) computational algorithms, (2) system software, (3) application software, (4) data management and exploration, (5) programming, and (6) software tools. The book has an interdisciplinary appeal: scholars from computational sub-fields in computer science, mathematics, physics, or engineering will find it of particular interest.
Recent Advances In Computational Engineering
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Author : Michael Schäfer
language : en
Publisher: Springer
Release Date : 2018-08-21
Recent Advances In Computational Engineering written by Michael Schäfer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Mathematics categories.
This book comprises the proceedings of the 4th International Conference on Computational Engineering (ICCE 2017), held in Darmstadt, Germany on September 28-29, 2017. The conference is intended to provide an interdisciplinary meeting place for researchers and practitioners working on computational methods in all disciplines of engineering, applied mathematics and computer science. The aims of the conference are to discuss the state of the art in this challenging field, exchange experiences, develop promising perspectives for future research and initiate further cooperation. Computational Engineering is a modern and multidisciplinary science for computer-based modeling, simulation, analysis, and optimization of complex engineering applications and natural phenomena. The book contains an overview of selected approaches from numerics and optimization of Partial Differential Equations as well as uncertainty quantification techniques, typically in multiphysics environments. Where possible, application cases from engineering are integrated. The book will be of interest to researchers and practitioners of Computational Engineering, Applied Mathematics, Engineering Sciences and Computer Science.
Boundary And Interior Layers Computational And Asymptotic Methods Bail 2018
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Author : Gabriel R. Barrenechea
language : en
Publisher: Springer Nature
Release Date : 2020-08-11
Boundary And Interior Layers Computational And Asymptotic Methods Bail 2018 written by Gabriel R. Barrenechea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-11 with Mathematics categories.
This volume gathers papers presented at the international conference BAIL, which was held at the University of Strathclyde, Scotland from the 14th to the 22nd of June 2018. The conference gathered specialists in the asymptotic and numerical analysis of problems which exhibit layers and interfaces. Covering a wide range of topics and sharing a wealth of insights, the papers in this volume provide an overview of the latest research into the theory and numerical approximation of problems involving boundary and interior layers.