Conjugates And Malignant Disease
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Conjugates And Malignant Disease
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Author : Michael Magerstadt
language : en
Publisher: CRC Press
Release Date : 1991-01-03
Conjugates And Malignant Disease written by Michael Magerstadt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-03 with Medical categories.
This book provides a comprehensive overview of antibody conjugates for in vivo applications. It discusses each of the major classes of antibody conjugates used in cancer diagnosis and therapy, as well as the major chemical and biological aspects of antibody selection, conjugate preparation, characterization, and application. The book is designed to close the information gap that exists regarding these compounds between such diverse disciplines as radiochemists, immunochemists, oncologists, clinicians and immunologists. It also provides a thorough overview for newcomers to the field.
Antibody Drug Conjugates And Immunotoxins
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Author : Gail Lewis Phillips
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-13
Antibody Drug Conjugates And Immunotoxins written by Gail Lewis Phillips and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-13 with Medical categories.
This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Antibody Drug Conjugates
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Author : Laurent Ducry
language : en
Publisher: Humana Press
Release Date : 2013-08-03
Antibody Drug Conjugates written by Laurent Ducry and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-03 with Medical categories.
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Immunoconjugates
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Author : Carl-Wilhelm Vogel
language : en
Publisher: Oxford University Press, USA
Release Date : 1987
Immunoconjugates written by Carl-Wilhelm Vogel and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Immunoconjugate research aims to develop improved methods of cancer detection and more effective, efficient drugs to combat cancer. This book contains contributions from virtually all established research groups in the immunotoxin field and offers a comprehensive discussion of current and potential applications of immunoconjugates, covering all pertinent topics from chemical synthesis to clinical trial.
Antibody Drug Conjugates
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Author : Kenneth J. Olivier, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2016-11-14
Antibody Drug Conjugates written by Kenneth J. Olivier, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Medical categories.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Immunology Of Malignant Diseases
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Author : V.S. Byers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunology Of Malignant Diseases written by V.S. Byers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Over the past 5 years, clinical immunology, as a whole, has advanced more rapidly than over the past 20 years. Many of these advances have been que to monoclonal antibody technology with its ability to identify antigens on tumour cells with a precision never before available. Monoclonal antibodies have the ability to identify subsets of human T-Iymphocytes and aid in diagnosis of both immunodeficiency disorders such as AIDS, or autoimmune diseases, and they can be adapted as drug targeting agents. Additionally, however, major advances have been made in identifying immunomodulating agents, and the last year has seen two such agents, IL-2 and OKT3, made available commercially for such intervention. Furthermore, another immuno modulating technique, bone marrow transplantation, ha~ now been established as a curative modality in leukaemia treatment. A central issue in tumour immunology is whether human tumours express antigens which can be termed tumour-specific. This has important implications for both tumour immunity as well as drug targeting. This issue is considered in detail by R. A. Robins in the introductory chapter in which the expression of antigens in human tumours is compared with that in experimentally induced animal tumours. This controversial issue is also considered in later chapters by Bast in breast carcinoma, Riimke and de Vries in melanoma, V{mky in lung cancer, Armitage in colorectal cancer, and Paulie and Perlmann in bladder carcinoma.
Cytotoxic Payloads For Antibody Drug Conjugates
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Author : David E Thurston
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-07-15
Cytotoxic Payloads For Antibody Drug Conjugates written by David E Thurston and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-15 with Medical categories.
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.
Antibody Drug Conjugates
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Author : Jeffrey Wang
language : en
Publisher: Springer
Release Date : 2015-03-05
Antibody Drug Conjugates written by Jeffrey Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-05 with Medical categories.
This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.
Antibody Drug Conjugates And Immunotoxins
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Author : Gail Lewis Phillips
language : en
Publisher: Springer
Release Date : 2012-12-12
Antibody Drug Conjugates And Immunotoxins written by Gail Lewis Phillips and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-12 with Medical categories.
This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Her2 Positive Breast Cancer
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Author : Sara Hurvitz
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-07-26
Her2 Positive Breast Cancer written by Sara Hurvitz and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-26 with Medical categories.
Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.