Copper Catalyzed Multi Component Reactions
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Copper Catalyzed Multi Component Reactions
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Author : Yusuke Ohta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-20
Copper Catalyzed Multi Component Reactions written by Yusuke Ohta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-20 with Science categories.
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Copper Catalyzed Multi Component Reactions
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Author : Yusuke Ohta
language : en
Publisher: Springer
Release Date : 2011-03-30
Copper Catalyzed Multi Component Reactions written by Yusuke Ohta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-30 with categories.
As the concept of Green Chemistry becomes ever more important, the findings presented in this book may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure.
Copper Catalysis In Organic Synthesis
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Author : Gopinathan Anilkumar
language : en
Publisher: John Wiley & Sons
Release Date : 2020-06-24
Copper Catalysis In Organic Synthesis written by Gopinathan Anilkumar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-24 with Technology & Engineering categories.
The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products.
Synthesis Of Heterocycles Via Multicomponent Reactions Ii
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Author : Romano V. A. Orru
language : en
Publisher: Springer
Release Date : 2010-07-26
Synthesis Of Heterocycles Via Multicomponent Reactions Ii written by Romano V. A. Orru and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-26 with Science categories.
Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery
Multi Component Reactions In Molecular Diversity
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Author : Jean-Philippe Goddard
language : en
Publisher: John Wiley & Sons
Release Date : 2020-04-28
Multi Component Reactions In Molecular Diversity written by Jean-Philippe Goddard and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-28 with Science categories.
While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.
Synthesis Of Heterocycles Via Multicomponent Reactions Ii
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Author :
language : en
Publisher:
Release Date : 2010
Synthesis Of Heterocycles Via Multicomponent Reactions Ii written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Chemical reactions categories.
Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery.
Multicomponent Reactions Towards Heterocycles
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Author : Erik Van der Eycken
language : en
Publisher: John Wiley & Sons
Release Date : 2022-03-21
Multicomponent Reactions Towards Heterocycles written by Erik Van der Eycken and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-21 with Science categories.
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.
Multicomponent Reactions
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Author : Raquel P. Herrera
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-01
Multicomponent Reactions written by Raquel P. Herrera and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with Science categories.
Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms
Multicomponent Reactions
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Author : Jieping Zhu
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Multicomponent Reactions written by Jieping Zhu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.
Multicomponent Reactions
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Author : Raquel P. Herrera
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-30
Multicomponent Reactions written by Raquel P. Herrera and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-30 with Science categories.
Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms