Cox 2 Blockade In Cancer Prevention And Therapy
DOWNLOAD
Download Cox 2 Blockade In Cancer Prevention And Therapy PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Cox 2 Blockade In Cancer Prevention And Therapy book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Cox 2 Blockade In Cancer Prevention And Therapy
DOWNLOAD
Author : Randall E. Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-10-03
Cox 2 Blockade In Cancer Prevention And Therapy written by Randall E. Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-03 with Medical categories.
The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.
Cox 2 Blockade In Cancer Prevention And Therapy
DOWNLOAD
Author : Randall E. Harris
language : en
Publisher:
Release Date : 2014-01-15
Cox 2 Blockade In Cancer Prevention And Therapy written by Randall E. Harris and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Cox 2
DOWNLOAD
Author : Joseph R. Bertino
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2003-01-01
Cox 2 written by Joseph R. Bertino and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-01 with Medical categories.
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both premalignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
Inflammation In The Pathogenesis Of Chronic Diseases
DOWNLOAD
Author : Randall E. Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-09
Inflammation In The Pathogenesis Of Chronic Diseases written by Randall E. Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-09 with Medical categories.
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Global Epidemiology Of Cancer
DOWNLOAD
Author : Randall E. Harris
language : en
Publisher: Jones & Bartlett Publishers
Release Date : 2016
Global Epidemiology Of Cancer written by Randall E. Harris and has been published by Jones & Bartlett Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Education categories.
In 28 chapters, Global Epidemiology of Cancer provides a basic overview of the most commonly occurring cancers, their worldwide incidence, and mortality. Designed for the health sciences, particularly those in epidemiology, public health, and medicine, this comprehensive resource is ideal as a primary text for an overview course or seminar on Cancer or Cancer epidemiology. Key Features: - Backed with research and draws upon worldwide information to address the global landscape of cancer. - Offers clear, concise descriptions of each specific type of oncologic disease as well as its epidemiology, etiology, risk factors and preventive factors - Includes a wealth of information on the pathogenesis of the disease as we currently understand it at the molecular level.
Ibuprofen
DOWNLOAD
Author : K. D. Rainsford
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-08
Ibuprofen written by K. D. Rainsford and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-08 with Medical categories.
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Oral Cancer And Precancer
DOWNLOAD
Author : Jens Jørgen Pindborg
language : en
Publisher: Butterworth-Heinemann
Release Date : 1980
Oral Cancer And Precancer written by Jens Jørgen Pindborg and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Cancer Chemoprevention
DOWNLOAD
Author : Gary J. Kelloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-04
Cancer Chemoprevention written by Gary J. Kelloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-04 with Medical categories.
Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.
Epidemiology Of Chronic Disease Global Perspectives
DOWNLOAD
Author : Randall E. Harris
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2019-04-15
Epidemiology Of Chronic Disease Global Perspectives written by Randall E. Harris and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-15 with Social Science categories.
Epidemiology of Chronic Disease: Global Perspectives is the most current and authoritative resource on the epidemiology, etiology, pathogenesis, risk factors and preventive factors of over 50 major chronic diseases and conditions. This comprehensive text provides readers with an excellent basis for examining current hypotheses regarding chronic disease epidemiology.
Progress In Cancer Prevention
DOWNLOAD
Author : Jakobe H. Bessiel
language : en
Publisher: Nova Publishers
Release Date : 2008
Progress In Cancer Prevention written by Jakobe H. Bessiel and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Cancer categories.
This book presents research on advances in genetics, molecular medicine, biotechnologies, and behavioural sciences that have an impact on primary, secondary and tertiary cancer prevention. It includes research on: Basic mechanisms of neoplastic diseases leading to the identification of molecular pathways that can be employed as targets for cancer prevention; Descriptive, analytical, and molecular epidemiology with emphasis on developing biomarkers of cancer risk assessment and response to cancer prevention; Laboratory and clinical procedures for prognostic evaluation of malignant tumour transformation, progression and response to treatment with cancer preventive agents; Discoveries of natural substances and synthetic agents that have promising cancer preventive potential and elucidating their mechanistic action; Development and assessment of cancer preventive approaches that have potential for being translated into the clinic; Cancer prevention pre-clinical studies and clinical trials; Patient management and education, management of curable lesions, education and lifestyle modification and the role of behavioural factors in cancer aetiology and prevention.