Cpp Cell Penetrating Peptides
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Cpp Cell Penetrating Peptides
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Author : Ülo Langel
language : en
Publisher: Springer
Release Date : 2019-06-03
Cpp Cell Penetrating Peptides written by Ülo Langel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-03 with Science categories.
In this book, a summary and update of the most important areas of CPP research are presented, whilst raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. The monograph is written for researchers and students in the field.
Cell Penetrating Peptides
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Author : Ülo Langel
language : en
Publisher:
Release Date : 2015
Cell Penetrating Peptides written by Ülo Langel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Cytology categories.
Divided into three parts this volume summarizes the most important areas of Cell-Penetrating Peptides (CPP) research . Partone briefly presents the historical background of CPP studies and the classifications of the available CPPs, and then summarizes the approaches for prediction of novel CPPs. Parttwo mainly describes the methods for studies of naked CPPs, that is, CPPs without conjugated cargos. Last but not least part threepresents a representative and brief summary of functionality issues of CPPs, both in vitro and in vivo. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, Cell-Penetrating Peptides: Methods and Protocols, Second Edition hopes to raise relevant questions for further development..
Cell Penetrating Peptides
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Author : Ulo Langel
language : en
Publisher: CRC Press
Release Date : 2002-05-29
Cell Penetrating Peptides written by Ulo Langel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-29 with Medical categories.
One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a
Handbook Of Cell Penetrating Peptides
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Author : Ulo Langel
language : en
Publisher: CRC Press
Release Date : 2006-08-15
Handbook Of Cell Penetrating Peptides written by Ulo Langel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-15 with Medical categories.
Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of new information on the use of these peptides as transport systems has in fact served to confound the field. The constant internal change in the field of cell-penetrating peptides (CPPs) is due to recent research uncovering apparent ambiguities in cellular upta
Cell Penetrating Peptides
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Author : Ülo Langel
language : en
Publisher: Humana
Release Date : 2015-07-24
Cell Penetrating Peptides written by Ülo Langel and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-24 with Science categories.
Divided into three parts this volume summarizes the most important areas of Cell-Penetrating Peptides (CPP) research . Part one briefly presents the historical background of CPP studies and the classifications of the available CPPs, and then summarizes the approaches for prediction of novel CPPs. Part two mainly describes the methods for studies of “naked” CPPs, that is, CPPs without conjugated cargos. Last but not least part three presents a representative and brief summary of functionality issues of CPPs, both in vitro and in vivo. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, Cell-Penetrating Peptides: Methods and Protocols, Second Edition hopes to raise relevant questions for further development.
Cell Penetrating Peptides
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Author : Sonia Aroui
language : en
Publisher:
Release Date : 2019
Cell Penetrating Peptides written by Sonia Aroui and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Computers categories.
Cell-penetrating peptide (CPP) is a term that describes relatively short amphipathic and cationic peptides (7,Äì30 amino acid residues) with rapid translocation across the cell membrane. They can be used to deliver molecular bioactive cargoes due to their efficacy in cellular internalization and also to their low cytotoxicity. In this review we provide an overview of the current approaches and describe the potential of CPP-based drug delivery systems and indicate their powerful promise for clinical efficacy.
Developments And Applications Of Cyclic Cell Penetrating Peptides
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Author : Ziqing Qian
language : en
Publisher:
Release Date : 2014
Developments And Applications Of Cyclic Cell Penetrating Peptides written by Ziqing Qian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Cell penetrating peptides (CPP) have been featured as a powerful delivery vector for the intracellular delivery of membrane-impermeable cargoes. This dissertation primarily focuses on the development, characterization, and application of a new class of CPP: cyclic cell penetrating peptides. Prompted by long-standing interests of the Pei group in developing cyclic peptides as biological tools and potential therapeutics, I describe our exploration of the permeability properties of the cyclic peptides, leading to the discovery that cyclic peptides with a short sequence motif rich in arginine and hydrophobic residues display significantly higher cellular permeability than their linear counterparts. The resulting cyclic CPP also translocated into the mammalian cell interior at significantly higher efficiencies than canonical arginine-rich linear CPPs. Subsequent internalization mechanistic investigations involving model lipid vesicles and pharmacological inhibitors, as well as genetic mutations, which perturb individual internalization steps, have shown conclusively that cyclic CPPs enter cells through endocytosis and are capable of escaping from early endosomes. To explore the utilities of cyclic CPP as cytoplasmic delivery vehicles, we developed endocyclic, exocyclic, and bicyclic delivery methods to deliver monocyclic peptides, bicyclic peptides, and proteins into cells. Biologically active cargoes, such as fluorogenic phosphatase substrates, phosphatase inhibitors, green fluorescent protein, and protein tyrosine phosphatase 1B were efficiently delivered by cyclic CPP. Additionally, we explored a potentially general strategy to deliver linear peptidyl ligands into mammalian cells through reversible, disulfide bond mediated cyclization. Cell permeable fluorogenic caspase substrates and cell-permeable CAL-PDZ domain inhibitors were developed using this method.
Cell Penetrating Peptides
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Author :
language : en
Publisher:
Release Date : 2010
Cell Penetrating Peptides written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Cell Penetrating Peptides
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Author : Makoto Oba
language : en
Publisher: John Wiley & Sons
Release Date : 2023-02-13
Cell Penetrating Peptides written by Makoto Oba and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-13 with Science categories.
The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.
Characterization Of Cell Penetrating Peptide Complexation And Interaction With Plant Cells
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Author : Jordan Tan Pepper
language : en
Publisher:
Release Date : 2015
Characterization Of Cell Penetrating Peptide Complexation And Interaction With Plant Cells written by Jordan Tan Pepper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Cell penetrating peptides (CPPs) are short 8-30 amino acid polypeptides that are able to transit across the semi-permeable plasma membrane of living cells, and deliver bound cargoes to the cytoplasm and other subcellular locations (e.g. nucleus, plastid organelles etc). The use of CPPs in plant cells and tissues remains a small and little researched field compared with the greater body of animal based research imperatives. The present research describes firstly, the measured interaction of the chosen model CPP Tat¬2 with the cell wall of microspores (i.e. microspore exine), secondly the reduction of the size and increase in regularity (measured as polydispersity) of Tat2 nucleic acid polyplexes and the unique empirical derivation of pseudo-kinetic parameters of nucleic acid CPP aggregation. Additionally several attempts to apply the findings from this research in plant cells and tissues are presented and discussed throughout.