Current Topics In Innate Immunity Ii
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Current Topics In Innate Immunity Ii
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Author : John D. Lambris
language : en
Publisher: Springer
Release Date : 2011-09-18
Current Topics In Innate Immunity Ii written by John D. Lambris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-18 with Medical categories.
Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
Current Topics In Innate Immunity Ii
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Author : John D. Lambris
language : en
Publisher: Springer
Release Date : 2011-09-23
Current Topics In Innate Immunity Ii written by John D. Lambris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-23 with Medical categories.
Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
Current Topics In Complement Ii
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Author : John D. Lambris
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-04
Current Topics In Complement Ii written by John D. Lambris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-04 with Medical categories.
Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.
Hot Topics In Infection And Immunity In Children Ii
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Author : Andrew J. Pollard
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-27
Hot Topics In Infection And Immunity In Children Ii written by Andrew J. Pollard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-27 with Medical categories.
Hot Topics in Infection and Immunity II provides a current view from leading experts concerning the hottest topics of concern to clinicians caring for children with infections. The book brings together a collection of manuscripts from a faculty of authors of international standing who contributed to a course in Paediatric Infection and Immunity in Oxford, UK in June 2004.
Epstein Barr Virus Volume 2
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Author : Christian Münz
language : en
Publisher: Springer
Release Date : 2015-10-01
Epstein Barr Virus Volume 2 written by Christian Münz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-01 with Medical categories.
Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.
Current Topics In Nonclinical Drug Development
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Author : Philip Bentley
language : en
Publisher: CRC Press
Release Date : 2023-11-09
Current Topics In Nonclinical Drug Development written by Philip Bentley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-09 with Science categories.
The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, study directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.
The Present And Future Of Immunology Education
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Author : Andrea Bottaro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-24
The Present And Future Of Immunology Education written by Andrea Bottaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-24 with Medical categories.
The explosion of basic and applied immunology in the first decades of the 21st century has brought forth new opportunities and challenges for immunology education at all academic levels, from professional to undergraduate, medical, graduate and post-graduate instruction. Moreover, developing methods and techniques for educating general audiences on the importance and benefits of immunology will be critical for increasing public awareness and support. One major immediate challenge consists in accommodating, within the confines of traditional immunology curricula, a body of knowledge that continues to grow exponentially in both size and complexity. Furthermore, the practical toolbox of immunological research has vastly expanded, and even in the present environment of highly interdisciplinary and collaborative science, future immunologists will likely need to be at least conversant in, for instance, computational, structural and system biology, nanotechnology and tissue engineering. At the same time, our perspective of the immune system has progressively developed from primarily a host defense mechanism to a fundamental homeostatic system with organism-wide physiological and clinical significance, and with potentially transformative biotechnological and therapeutic applications. As a consequence, in addition to stand-alone courses, immunology is increasingly integrated into other courses, or distributed longitudinally, throughout a multi-year curriculum. This necessitates inter-disciplinary approaches to reach an expanding range of disciplines, as diverse as neurobiology, cancer biology/ oncology, infectious diseases, pharmacology, orthopedics and bioengineering. Creative approaches and pedagogical flexibility will be needed to avoid the pitfall of “one-size-fits-all” instruction, and to tailor level- and discipline-appropriate content to different types of students using multiple teaching formats. Finally, like most other disciplines, immunology education is also under strong pressure to introduce new didactic strategies that are relevant and meaningful to a generation of students who are “digital natives”, comfortable with and expect on-demand and multi-modal learning, diversified sources, and active engagement. Thankfully, the dynamic and interactive behavior of immune system cells, now visualized with striking immediacy by in vivo imaging, has the ability to capture and hold the interest of even the most jaded learner. The need for an increasingly immunology-knowledgeable workforce – not just academic and industry scientists, but also clinical and research lab technicians, biomedical engineers, and physicians in a growing array of specialties - will also expand job opportunities for immunologists as educators, and for content creators dedicated to generating new didactic tools in this field. Acknowledgement: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).
In The Shadow Of Animals
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Author : Michael Hehenberger
language : en
Publisher: CRC Press
Release Date : 2024-10-03
In The Shadow Of Animals written by Michael Hehenberger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-03 with Medical categories.
What differentiates humans from other living beings is our ability to communicate, our complex reasoning, and our use of skilled hands and smart brains to build houses, cities, and societies. We are able to learn. We penetrate into the unknown. We dominate our planet. For thousands of years, we have lived close to animals. As we are gaining a more complete understanding of our physiology, we are observing that we are not so different from them and other life forms. By studying them, we can sharpen our senses, treat diseases, and overcome some of our weaknesses. By observing their unique capabilities, we invent ways to emulate their performances in areas where evolution has helped them excel. Animals have helped us build our human culture and civilization. We still take advantage of them, even push them back into ever more restricted habitats. We are now at risk of forgetting that Sapiens’ only way to thrive, and planet Earth to survive, will be to humbly accept our place in the “shadow of animals.” This book explains how various animals have adapted to extreme conditions, and why humans need to study animals and should protect them. It helps us to understand how “life on our planet” evolved. It is a popular presentation of the human–animal relationship for curious readers of all ages. It will hopefully stimulate scientific discussions among high school and university students.
Influenza Pathogenesis And Control Volume Ii
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Author : Michael B. A. Oldstone
language : en
Publisher: Springer
Release Date : 2014-11-06
Influenza Pathogenesis And Control Volume Ii written by Michael B. A. Oldstone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-06 with Medical categories.
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Our Animal Connection
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Author : Michael Hehenberger
language : en
Publisher: CRC Press
Release Date : 2020-12-09
Our Animal Connection written by Michael Hehenberger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Medical categories.
This book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on the planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. The authors discuss the strengths and weaknesses of Homo sapiens, and how the study of animals can make us stronger and healthier. To deepen our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve human performance, we can study the animal kingdom’s top performers and learn from their successes. Considering these important pointers, the authors review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance. Finally, they discuss the challenges associated with our animal connection: the history of pandemics caused by bacterial and viral pathogens demonstrates that there is a risk for transmission of diseases that can disrupt human societies. The recent COVID-19 outbreak is covered in detail as an example.