Cutaneous Drug Hypersensitivity

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Cutaneous Drug Hypersensitivity

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Author : Andreas J. Bircher
language : en
Publisher: Springer Nature
Release Date : 2022-07-09

Cutaneous Drug Hypersensitivity written by Andreas J. Bircher and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-09 with Medical categories.

This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivity is among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.

Adverse Cutaneous Drug Eruptions

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Author : Lars E. French
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012

Adverse Cutaneous Drug Eruptions written by Lars E. French and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.

An indispensable tool for understanding, diagnosing and managing this common clinical problem The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1-5% for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists.

Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions

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Author : Neil H. Shear
language : en
Publisher: Springer
Release Date : 2018-10-19

Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions written by Neil H. Shear and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-19 with Medical categories.

This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development. The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.

Adverse Cutaneous Drug Reactions To Cardiovascular Drugs

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Author : Esen Özkaya
language : en
Publisher: Springer
Release Date : 2014-11-15

Adverse Cutaneous Drug Reactions To Cardiovascular Drugs written by Esen Özkaya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-15 with Medical categories.

Adverse cutaneous drug reactions (ACDR) are among the most frequent events in patients receiving drug therapy. Cardiovascular (CV) drugs are an important group of drugs with potential risk of developing ACDR especially in elderly as marketing of more new drugs and their prescription continue to increase. However, like with most other drugs the exact incidence of cutaneous side effects from CV drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable designation of a certain drug as the cause of a certain type of reaction can rarely be made. Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. In this comprehensive review, the reported types of ACDR to CV drugs will be discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis.

Drug Hypersensitivity And Desensitizations An Issue Of Immunology And Allergy Clinics Of North America E Book

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Author : Mariana C. Castells
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-10-06

Drug Hypersensitivity And Desensitizations An Issue Of Immunology And Allergy Clinics Of North America E Book written by Mariana C. Castells and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-06 with Medical categories.

This issue of Immunology and Allergy Clinics, guest edited by Mariana Castells, is devoted to Drug Hypersensitivity and Desensitizations. Articles in this issue include: Principles and Practice of Drug Desensitization; Incidence and Prevalence of Drug Hypersensitivity; Drug-Induced Anaphylaxis; Penicillin and Beta Lactam Hypersensitivity; Platins Chemotherapy Hypersensitivity: Prevalence and Management; Monoclonal Antibodies Hypersensitivity: Prevalence and Management; Injectable Drugs and MoAbs Reactions and Management with Desensitization; Delayed Cutaneous Reactions to Antibiotics, Management with Desensitization; Management of Children with Hypersensitivity to Antibiotics and MoAbs; Taxenes Hypersensitivity and Management; Progesterone Autoimmune Dermatitis; Severe Delayed Drug Reaction: Role of Genetics and Viral Infections; andAspirin and NSAIDS Hypersensitivity and Management.

Drug Hypersensitivity

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Author : Werner J. Pichler
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2007-01-01

Drug Hypersensitivity written by Werner J. Pichler and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.

Approaches the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in this book. The book also covers clinical manifestations and new diagnostic methods, and introduces some recetly established animal models. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced.

Monographs In Contact Allergy Volume 4

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Author : Anton C. de Groot
language : en
Publisher: CRC Press
Release Date : 2022-03-09

Monographs In Contact Allergy Volume 4 written by Anton C. de Groot and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Medical categories.

This fourth volume in an exciting and detailed series on contact allergens and drug allergy provides monographs of all 507 systemic drugs which have caused delayed-type cutaneous drug hypersensitivity reactions and/or occupational allergic contact dermatitis. The monographs present: Identification section; Occupational allergic contact dermatitis; and Cutaneous adverse drug reactions from systemic drugs caused by type IV (delayed-type) hypersensitivity, as shown by positive patch tests (e.g. maculopapular eruption, acute generalized exanthematous pustulosis [AGEP], symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], fixed drug eruption, drug reaction with eosinophilia and systemic symptoms [DRESS], and photosensitivity). Separate chapters present an overview of the spectrum of allergic cutaneous drug reactions, diagnostic tests, immediate contact reactions (contact urticaria), and systemic drugs that have acquired delayed-type hypersensitivity only by cross-reactivity. Key Features: Presents monographs of all known systemic drugs which have caused delayed allergic cutaneous drug reactions and/or occupational allergic contact dermatitis Provides an extensive literature review of relevant topics of allergenic systemic drugs, part of which is hard or impossible to find in database searches Identifies IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing Presents immediate contact reactions (contact urticaria) from systemics drugs and delayed-type hypersensitivity in drugs caused only by cross-reactivity Covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy

Drug Allergy

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Author : Brian A. Baldo
language : en
Publisher: Springer Nature
Release Date : 2020-12-08

Drug Allergy written by Brian A. Baldo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Medical categories.

The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms. This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book’s mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies. The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.

Cutaneous Drug Eruptions

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Author : John C. Hall
language : en
Publisher: Springer
Release Date : 2015-08-21

Cutaneous Drug Eruptions written by John C. Hall and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Medical categories.

​The burden of cutaneous drug reactions is significant, in both outpatient and inpatient settings, and can result in morbidity and even mortality. This book is unique in its approach to this problem. This text is divided into basic principles, common drug reactions, skin conditions mimicked by drug reactions, drug reactions to the skin appendages, life-threatening drug reactions, less common drug reactions, and special groupings of drug reactions. For the clinician, the skin can only morphologically react in to many limited ways. This is also true for the pathologist. Combining these two forever linked specialties is a synergistic paradigm that greatly enhances diagnosis, and ultimately therapy, for these pernicious conditions. Drug reactions in the skin remain a common complication of therapy. True incidences of drug reactions are not available. For general discussion, the rule of 3% can be applied with reasonable assuredness. Approximately 3% of all hospitalized patients develop an adverse cutaneous drug reaction. Approximately 3% of these reactions are considered severe. Outpatient data is even more obscure, but at least 3% of dermatology clinic outpatient visits are due to a drug reaction. Cutaneous drug reactions compromise approximately 3% of all drug reactions. Even more challenging is the fact that the most vulnerable populations to drug reactions are increasing and include the elderly patients on prolonged drug therapy, and patients that use multiple drugs at the same time.

Drug Hypersensitivity An Issue Of Immunology And Allergy Clinics

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Author : Pascal Demoly
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-08-28

Drug Hypersensitivity An Issue Of Immunology And Allergy Clinics written by Pascal Demoly and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-28 with Medical categories.

This issue of Immunology and Allergy Clinics, edited by Dr. Pascal Demoly, is devoted to Drug Hypersensitivity. Articles in this issue include: Drug allergy diagnosis; Principles of drug allergy management: acute drug reactions, individual preventive measures, desensitization, general preventive measures; Antibiotics allergy; Non-steroidal anti-inflammatory drugs HS; Local and general anesthetics allergy; Radiocontrast media and dyes allergy; Chemotherapeutic agents allergy; Vaccine allergy; Biological agents HS; Anti-epileptic allergy; Iron and Vitamin Allergy; Antiviral drug allergy; Additive allergy; and Unmet needs in drug allergy.