Cytokine And Chemokine Networks In Cancer
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Cytokine And Chemokine Networks In Cancer
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Author : Manzoor Ahmad Mir
language : en
Publisher: Springer Nature
Release Date : 2023-10-19
Cytokine And Chemokine Networks In Cancer written by Manzoor Ahmad Mir and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-19 with Medical categories.
Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
The Inflammatory Milieu Of Tumors
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Author : Adit Ben-Baruch
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-06-29
The Inflammatory Milieu Of Tumors written by Adit Ben-Baruch and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.
"Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious micro-environmental factors. The tumor microenvironment contains stroma cel"
The Cytokine Network In Colorectal Cancer Implications For New Treatment Strategies
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Author : Heidi Braumüller
language : en
Publisher:
Release Date : 2022
The Cytokine Network In Colorectal Cancer Implications For New Treatment Strategies written by Heidi Braumüller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Abstract: Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only limited therapeutic options. CRC is not only a genetic disease with several mutations in specific oncogenes and/or tumor suppressor genes such as APC, KRAS, PIC3CA, BRAF, SMAD4 or TP53 but also a multifactorial disease including environmental factors. Cancer cells communicate with their environment mostly via soluble factors such as cytokines, chemokines or growth factors to generate a favorable tumor microenvironment (TME). The TME, a heterogeneous population of differentiated and progenitor cells, plays a critical role in regulating tumor development, growth, invasion, metastasis and therapy resistance. In this context, cytokines from cancer cells and cells of the TME influence each other, eliciting an inflammatory milieu that can either enhance or suppress tumor growth and metastasis. Additionally, several lines of evidence exist that the composition of the microbiota regulates inflammatory processes, controlled by cytokine secretion, that play a role in carcinogenesis and tumor progression. In this review, we discuss the cytokine networks between cancer cells and the TME and microbiome in colorectal cancer and the related treatment strategies, with the goal to discuss cytokine-mediated strategies that could overcome the common therapeutic resistance of CRC tumors
Systems Biology Of Cancer
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Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09
Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Inflammation Driven Pro Malignant Networks In Breast Cancer Tnf And Il 1 As Regulators Of Inflammatory Chemokines Emt And Tumor Progression
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Author : Tal Leibovich-Rivkin
language : en
Publisher:
Release Date : 2015
Inflammation Driven Pro Malignant Networks In Breast Cancer Tnf And Il 1 As Regulators Of Inflammatory Chemokines Emt And Tumor Progression written by Tal Leibovich-Rivkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Chemokines
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Author : Keith J. Walker
language : en
Publisher: Nova Biomedical Books
Release Date : 2011
Chemokines written by Keith J. Walker and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Chemokines categories.
Chemokines are a family of small cytokines, or proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. The major role of chemokines is to act as a chemoattractant to guide the migration of cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. This book presents current research in the study of chemokines from across the globe, including such topics as development of chemokine network targeting agents for the treatment of allergic, autoimmune and inflammatory diseases and cancers; chemokines in teleost fish species; gene regulation of chemokines in response to bacterial enterotoxins; and the role of chemokines in colorectal cancer and metastasis.
Chemokine Receptors In Cancer
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Author : Amy Fulton
language : en
Publisher: Humana Press
Release Date : 2009-05-27
Chemokine Receptors In Cancer written by Amy Fulton and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-27 with Medical categories.
Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.
Cytokine Networks And Immunosurveillance In Cancer
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Author : Timothy Chao
language : en
Publisher:
Release Date : 2017
Cytokine Networks And Immunosurveillance In Cancer written by Timothy Chao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
The cytokine milieu in the tumor microenvironment plays a key role in modulating the immune response either in favor of or against tumorigenesis. For many tumors, this complex network of cytokine and immune interactions represent a formidable means of escape from immune surveillance. These cytokine networks are particularly important in pancreatic ductal adenocarcinoma (PDA), where a prominent infiltration of immunosuppressive immune populations could be found. Myeloid-derived suppressor cells (MDSCs) have previously been shown to be potent suppressors of anti-tumor immunity in PDA, but the cytokine networks regulating their recruitment to the tumor microenvironment remain incompletely understood. Here, I found that CXCR2 ligand expression is specifically correlated with enrichment of the granulocytic subset of MDSCs (G-MDSCs) in human PDAs. Using a genetically engineered mouse model of PDA, I showed that CXCR2 is required for G-MDSC trafficking to the tumor microenvironment, but not necessary for their systemic differentiation and expansion. The specific lack of G-MDSCs in the tumor microenvironment led to a T cell-dependent inhibition of tumor growth. Expression of CXCR2 ligands in PDA tumor cells can be potently induced by NF-?B activation. These findings describe a cytokine network in PDA where inflammatory signals in the tumor microenvironment drive the expression of CXCR2 ligands and the recruitment of immunosuppressive G-MDSCs. To discover other potentially important cytokine networks, I developed a novel analysis pipeline to reconstruct and compare cytokine networks from whole tumor gene expression data. Using expression of cytolytic genes as a gauge for anti-tumor immune activity, I found that PDA patients with high cytolytic activity have a slight survival advantage compared to those with lower activity. While macrophages were the most influential in tumors with low cytolytic activity, tumors with high cytolytic activity were characterized by increased activity of NK cells, recruitment of B cells, and increased importance of CD8 T cells, CD4 T helper cells, and B cells, among others. I further highlighted the cytokines that might be associated with these immune populations. Therefore, my analysis identified potentially important components of the cytokine network associated with high and low cytolytic activity. Collectively, the work in this thesis suggests that cytokine networks are crucial for maintaining an immunosuppressive microenvironment in cancer. Furthermore, disrupting key components of these networks can tip the balance in favor of cancer immunosurveillance.
Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Chemokines And Cancer
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Author : Barrett Rollins
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04-09
Chemokines And Cancer written by Barrett Rollins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-09 with Medical categories.
Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.