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Chemokines And Cancer


Chemokines And Cancer
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Chemokine Receptors In Cancer


Chemokine Receptors In Cancer
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Author : Amy M. Fulton
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-12

Chemokine Receptors In Cancer written by Amy M. Fulton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.


Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.



Tumor Microenvironment


Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher: Springer
Release Date : 2020-02-15

Tumor Microenvironment written by Alexander Birbrair and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-15 with Science categories.


Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part A updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking a comprehensive update on research in the tumor microenvironment.



Chemokines And Cancer


Chemokines And Cancer
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Author : Barrett Rollins
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04-09

Chemokines And Cancer written by Barrett Rollins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-09 with Medical categories.


Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.



The Inflammatory Milieu Of Tumors


The Inflammatory Milieu Of Tumors
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Author : Adit Ben-Baruch
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-06-29

The Inflammatory Milieu Of Tumors written by Adit Ben-Baruch and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.


"Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious micro-environmental factors. The tumor microenvironment contains stroma cel"



Chemokines And Skin


Chemokines And Skin
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Author : Kownatzki
language : en
Publisher: Birkhäuser
Release Date : 2012-10-13

Chemokines And Skin written by Kownatzki and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-13 with Medical categories.


The accumulation of white blood cells is a hallmark of inflammation. The penetra tion through the vessel walls and the infiltration around the inflammatory stimulus is a complex process which involves active adherence and directed migration of the inflammatory cells. Chemotactic factors stimulate both adherence and migration. Technical tools such as the Boyden chamber [1] made it possible to study leukocyte migration in vitro. This technique allows differentiation between migration direct ed towards a chemotactic stimulus and non-directed migration. Until a decade ago only two naturally occurring molecules had been clearly iden tified as potent chemotactic attractants of neutrophilic granulocytes. They were the split product of the fifth complement component C5a [2] and the arachidonic acid metabolite leukotriene B4 [3]. In 1986, a novel human monocyte-derived chemo taxin attracting neutrophilic granulocytes with a similar potency was found [4]. This report was quickly confirmed by several groups [5-8]. The new factor was purified, cloned and sequenced [9, 10]. The term "interleukin 8" (IL-8) replaced the various names proposed previously [4-8]. Sequence data revealed that IL-8 belonged to a large family of chemotactic cytokines, now called "chemokines" [11]. Four subfamilies were distinguished on the basis of the number and position of the first cysteine residues. They are desig nated accordingly as C, CC, CXC and CX C chemokines [11-13]. The number of 3 human chemokines identified so far is close to 40 [11-13].



Chemokines Chemokine Receptors And Disease


Chemokines Chemokine Receptors And Disease
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Author : Lisa M. Schwiebert
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-09-02

Chemokines Chemokine Receptors And Disease written by Lisa M. Schwiebert and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-02 with Medical categories.


This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research



The Role Of Chemoattractants In The Tumor Microenvironment


The Role Of Chemoattractants In The Tumor Microenvironment
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Author : Giovanni Bernardini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-27

The Role Of Chemoattractants In The Tumor Microenvironment written by Giovanni Bernardini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-27 with categories.




Chemokine Biology Basic Research And Clinical Application


Chemokine Biology Basic Research And Clinical Application
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Author : Bernhard Moser
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-16

Chemokine Biology Basic Research And Clinical Application written by Bernhard Moser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-16 with Medical categories.


Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.



Understanding The Crosstalk Between Immune Cells And The Tumor Microenvironment In Cancer And Its Implications For Immunotherapy


Understanding The Crosstalk Between Immune Cells And The Tumor Microenvironment In Cancer And Its Implications For Immunotherapy
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Author : Noha Mousaad Elemam
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13

Understanding The Crosstalk Between Immune Cells And The Tumor Microenvironment In Cancer And Its Implications For Immunotherapy written by Noha Mousaad Elemam and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Medical categories.


One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.



Cytokine And Chemokine Networks In Cancer


Cytokine And Chemokine Networks In Cancer
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Author : Manzoor Ahmad Mir
language : en
Publisher: Springer Nature
Release Date : 2023-10-19

Cytokine And Chemokine Networks In Cancer written by Manzoor Ahmad Mir and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-19 with Medical categories.


Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.