Tumor Microenvironment
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Tumor Microenvironment
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Author : Jacinta Serpa
language : en
Publisher: Springer Nature
Release Date : 2020-03-04
Tumor Microenvironment written by Jacinta Serpa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Medical categories.
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2020-10-29
Tumor Microenvironment written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-29 with Medical categories.
This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Tumor Microenvironment Cellular Metabolic And Immunologic Interactions
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Author : Debabrata Banerjee
language : en
Publisher: Springer Nature
Release Date : 2021-12-09
Tumor Microenvironment Cellular Metabolic And Immunologic Interactions written by Debabrata Banerjee and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-09 with Medical categories.
Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Biomarkers Of The Tumor Microenvironment
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Author : Lars A. Akslen
language : en
Publisher: Springer Nature
Release Date : 2022-07-12
Biomarkers Of The Tumor Microenvironment written by Lars A. Akslen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with Medical categories.
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.
Manipulating The Immunological Tumor Microenvironment
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Author : Peng Qu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-31
Manipulating The Immunological Tumor Microenvironment written by Peng Qu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Medical categories.
The Extracellular Matrix And The Tumor Microenvironment
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Author : Ilona Kovalszky
language : en
Publisher: Springer Nature
Release Date : 2022-07-06
The Extracellular Matrix And The Tumor Microenvironment written by Ilona Kovalszky and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-06 with Medical categories.
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Innate And Adaptive Immunity In The Tumor Microenvironment
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Author : Eitan Yefenof
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-20
Innate And Adaptive Immunity In The Tumor Microenvironment written by Eitan Yefenof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-20 with Medical categories.
Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.
Autophagy In Tumor And Tumor Microenvironment
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Author : Sujit Kumar Bhutia
language : en
Publisher: Springer Nature
Release Date : 2020-10-24
Autophagy In Tumor And Tumor Microenvironment written by Sujit Kumar Bhutia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Medical categories.
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Role Of Tumor Microenvironment In Breast Cancer And Targeted Therapies
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Author : Manzoor Ahmad Mir
language : en
Publisher: Elsevier
Release Date : 2022-08-10
Role Of Tumor Microenvironment In Breast Cancer And Targeted Therapies written by Manzoor Ahmad Mir and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-10 with Computers categories.
Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumorigenicity and the development of therapeutic resistance, along with updates on recent advances. - Presents up-to-date knowledge on the interplays of stromal components surrounding breast tumor cells - Explores recent advances and trends in the molecular mechanisms of breast tumorigenesis and how to explore further molecular targets
Tumor Vessels As Directors Of The Tumor Microenvironment New Findings Current Challenges Perspectives
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Author : Lucas Treps
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-22
Tumor Vessels As Directors Of The Tumor Microenvironment New Findings Current Challenges Perspectives written by Lucas Treps and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-22 with Science categories.