Innate And Adaptive Immunity In The Tumor Microenvironment
DOWNLOAD
Download Innate And Adaptive Immunity In The Tumor Microenvironment PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Innate And Adaptive Immunity In The Tumor Microenvironment book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Innate And Adaptive Immunity In The Tumor Microenvironment
DOWNLOAD
Author : Eitan Yefenof
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-20
Innate And Adaptive Immunity In The Tumor Microenvironment written by Eitan Yefenof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-20 with Medical categories.
Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.
Innate And Adaptive Immunity In The Tumor Microenvironment
DOWNLOAD
Author : Eitan Yefenof
language : en
Publisher: Springer
Release Date : 2009-09-03
Innate And Adaptive Immunity In The Tumor Microenvironment written by Eitan Yefenof and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Medical categories.
Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.
Nkt Cells In Cancer Immunotherapy 2nd Edition
DOWNLOAD
Author : Tonya J. Webb
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-20
Nkt Cells In Cancer Immunotherapy 2nd Edition written by Tonya J. Webb and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Harnessing Oncolytic Virus Mediated Antitumor Immunity
DOWNLOAD
Author : Philippe Fournier
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-02
Harnessing Oncolytic Virus Mediated Antitumor Immunity written by Philippe Fournier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-02 with Cancer categories.
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus
DOWNLOAD
Author : Wantao Wu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus written by Wantao Wu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
The interplay between cancer cells and the immune system is a critical area of research, with recent advancements highlighting the potential of immunotherapy in offering durable responses across various cancer types. Immune checkpoint inhibitors, in particular, have emerged as a cornerstone of cancer therapy, transforming patient outcomes. However, the heterogeneity of tumor-immune interactions poses significant challenges, with a considerable fraction of patients not responding to such treatments. This underscores the urgent need for a deeper understanding of the molecular and cellular underpinnings of these interactions, to harness the full potential of immunotherapy. This Research Topic aims to address the complex landscape of tumor-immune interactions, focusing on identifying and leveraging novel biomarkers and mechanisms that can predict and enhance the efficacy of immunotherapy. Given the pivotal role of the immune system in controlling and eradicating cancer, understanding these interactions at a granular level could lead to more personalized and effective treatment strategies. Recent advances in technologies such as next-generation sequencing, single-cell RNA sequencing, and mass cytometry have opened new avenues for dissecting the complexity of the tumor microenvironment and immune evasion strategies. This collection seeks to compile cutting-edge research that employs these technologies to uncover new biomarkers, understand resistance mechanisms, and identify potential therapeutic targets within the immune contexture of tumors. By bridging gaps in knowledge and fostering innovation, this topic aims to propel the field towards more predictive and responsive immunotherapy approaches.
Tumor Microenvironments In Organs
DOWNLOAD
Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2021-06-29
Tumor Microenvironments In Organs written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Medical categories.
Revealing essential roles of the tumor microenvironment components in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in several organs, including brain, neck, tongue, larynges, esophagus, carotid body, breast, prostate, ovary, endometrium, liver, pancreas, bladder, penis, seminal vesicle, retina, and pituitary, pineal and sweat glands, and more. Taken alongside its companion volumes, Tumor Microenvironments in Organs: From the Brain to the Skin – Part B updates us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Tumor Ecosystem
DOWNLOAD
Author : Erwei Song
language : en
Publisher: Springer Nature
Release Date : 2023-07-20
Tumor Ecosystem written by Erwei Song and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-20 with Medical categories.
This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
Tissue Resident Immune Cells In Tumor Immunity And Immunotherapy
DOWNLOAD
Author : Wu Qi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-22
Tissue Resident Immune Cells In Tumor Immunity And Immunotherapy written by Wu Qi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-22 with Science categories.
Tumor Micro Environment And Drug Resistance
DOWNLOAD
Author : Wei Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-16
Tumor Micro Environment And Drug Resistance written by Wei Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
DOWNLOAD
Author : Patrik Andersson
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy written by Patrik Andersson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.