Tumor Ecosystem
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Tumor Ecosystem
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Author : Erwei Song
language : en
Publisher: Springer Nature
Release Date : 2023-07-20
Tumor Ecosystem written by Erwei Song and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-20 with Medical categories.
This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
Cancer Ecosystems
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Author : Ubaldo E. Martinez-Outschoorn
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-27
Cancer Ecosystems written by Ubaldo E. Martinez-Outschoorn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-27 with categories.
Individualized Patient Derived Tumor Organoids Model Brain Tumor Ecosystem
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Author : Xiujian Ma
language : en
Publisher:
Release Date : 2023
Individualized Patient Derived Tumor Organoids Model Brain Tumor Ecosystem written by Xiujian Ma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Ecology And Evolution Of Cancer
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Author : Beata Ujvari
language : en
Publisher: Academic Press
Release Date : 2017-02-08
Ecology And Evolution Of Cancer written by Beata Ujvari and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
From Ecology To Cancer Biology And Back Again
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Author : Frederick R. Adler
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-08
From Ecology To Cancer Biology And Back Again written by Frederick R. Adler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-08 with Science categories.
Head And Neck Cancer Hallmarks Of The Inflammation Ecosystem
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Author : Norhafiza Mat Lazim
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-03-31
Head And Neck Cancer Hallmarks Of The Inflammation Ecosystem written by Norhafiza Mat Lazim and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-31 with Medical categories.
This reference comprehensively covers the clinical aspects of head and neck neoplasms while also highlighting the relationship that exists between inflammation and these cancers. This relationship is critical as it dictates the risks, assessment, treatment, and prognosis of head and neck cancer patients. The book starts with an introduction to the inflammation ecosystem in head and neck malignancy, followed by detailed discussions on the types of head and neck malignancy and their histological classification. The book then provides information about specialized topics relevant to the specialty of head and neck oncology. Key Features: - Comprehensive coverage of head and neck cancers with topic-based chapters - Introductory text explaining the basics of inflammation - Detailed information on the relationship between inflammation and head and neck neoplasms - Information about the classification of head and neck cancers - Methods for diagnosis and treatment - Special topics such as complications caused by HPV infections, chemoradiation, immune-targeted therapy, and inflammatory biomarkers - References for further reading The combination of basic and advanced topics makes this book an informative reference for medical students and professionals at all levels. Residents specializing in otolaryngology, oncology, and surgery as well as researchers studying inflammation will also gain an understanding of the subject in relation to oncogenesis.
Mechanisms Of Invasion And Metastasis
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Author : Marc M. Mareel
language : en
Publisher: CRC Press
Release Date : 1991-04-23
Mechanisms Of Invasion And Metastasis written by Marc M. Mareel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-04-23 with Medical categories.
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
Cancer Through The Lens Of Evolution And Ecology
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Author : Jason A. Somarelli
language : en
Publisher: CRC Press
Release Date : 2024-05-29
Cancer Through The Lens Of Evolution And Ecology written by Jason A. Somarelli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with Medical categories.
Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.
Liquid Biopsy A Tool For Better Understanding Of The Metastatic Process Ecosystem
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Author : Elisabetta Rossi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-21
Liquid Biopsy A Tool For Better Understanding Of The Metastatic Process Ecosystem written by Elisabetta Rossi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-21 with Medical categories.
Cancer Microenvironment And Therapeutic Implications
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Author : Gianfranco Baronzio
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-10
Cancer Microenvironment And Therapeutic Implications written by Gianfranco Baronzio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-10 with Medical categories.
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.