Ecology And Evolution Of Cancer
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Ecology And Evolution Of Cancer
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Author : Beata Ujvari
language : en
Publisher: Academic Press
Release Date : 2017-02-08
Ecology And Evolution Of Cancer written by Beata Ujvari and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
From Ecology To Cancer Biology And Back Again
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Author : Frederick R. Adler
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-08
From Ecology To Cancer Biology And Back Again written by Frederick R. Adler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-08 with Science categories.
Cancer And Evolution
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Author : Jason A Somarelli
language : en
Publisher:
Release Date : 2024-06-03
Cancer And Evolution written by Jason A Somarelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-03 with categories.
New cancer cells exist an ever-changing "ecology" and are subject to evolutionary pressures just like any species in nature. The book is resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.
Frontiers In Cancer Research
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Author : Carlo C. Maley
language : en
Publisher: Springer
Release Date : 2016-11-21
Frontiers In Cancer Research written by Carlo C. Maley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Medical categories.
This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
Evolution By Tumor Neofunctionalization
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Author : Andrei P. Kozlov
language : en
Publisher: Academic Press
Release Date : 2014-02-15
Evolution By Tumor Neofunctionalization written by Andrei P. Kozlov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-15 with Science categories.
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology. Covers the role that tumors might play in evolution. Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more
The Cheating Cell
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Author : Athena Aktipis
language : en
Publisher: Princeton University Press
Release Date : 2021-09-07
The Cheating Cell written by Athena Aktipis and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-07 with Medical categories.
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Cancer Selection
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Author : James Graham
language : en
Publisher: Aculeus Pr
Release Date : 1992
Cancer Selection written by James Graham and has been published by Aculeus Pr this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
Conventional evolutionary theory cannot explain the existence of humans & other complex animals; another mechanism is needed, says James Graham, & it is none other than cancer. This radical theory, already published in a science journal, is aimed at amateurs & professionals. "I think I agree with him... a good idea," John W. Galloway, Nature. "Intriguing...resolves many outstanding problems," SciTech Book News. Literary reviewers like it too: "absorbing...provocative." The Small Press Book Review. "fascinating...sheer intellectual virtuosity." West Coast Review of Books. "distinguished." The Book Reader. Order from: James Graham, PO Box 142, Lexington Virginia 24450 telephone 540 464 4554. Also available from Amazon.com, Barnes & Noble and other retailers.
Cancer Ecosystems
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Author : Ubaldo E. Martinez-Outschoorn
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-27
Cancer Ecosystems written by Ubaldo E. Martinez-Outschoorn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-27 with categories.
Cancer Evolution
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Author : Charles Swanton
language : en
Publisher: Perspectives Cshl
Release Date : 2017
Cancer Evolution written by Charles Swanton and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
The Selfish Cell
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Author : Matteo Conti
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-25
The Selfish Cell written by Matteo Conti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-25 with Medical categories.
A long time has passed since the war act on Cancer declared by former USA president Nixon, almost half a century ago. Today, after so many years of feverish research and uncountable efforts worldwide, the end of the war appears far as ever, whereas the fight is leading researchers to newer and newer battlefronts while frontiers in bioscience are continuously being surpassed. In this scenario, “The Selfish Cell” is a script record of the most important strategic points gathered during these years of war, with the goal to provide solid ground onto which to step ahead for future assaults against this terrible disease. At the same time, it is an attempt to shift the debate on cancer toward a more peaceful and possibly productive semantic terrain, where to reflect with the aid of superior wisdom to finally get out of that terrible chaos of fight and death dominating our days. In this perspective, “The selfish cell” becomes an occasion for reflecting the limits of our human selfishness and their consequences on both our social and natural environment.