From Ecology To Cancer Biology And Back Again
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From Ecology To Cancer Biology And Back Again
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Author : Frederick R. Adler
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-08
From Ecology To Cancer Biology And Back Again written by Frederick R. Adler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-08 with Science categories.
Cancer Through The Lens Of Evolution And Ecology
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Author : Jason A. Somarelli
language : en
Publisher: CRC Press
Release Date : 2024-05-29
Cancer Through The Lens Of Evolution And Ecology written by Jason A. Somarelli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with Medical categories.
Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.
Ecology And Evolution Of Cancer
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Author : Beata Ujvari
language : en
Publisher: Academic Press
Release Date : 2017-02-08
Ecology And Evolution Of Cancer written by Beata Ujvari and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
The Cheating Cell
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Author : Athena Aktipis
language : en
Publisher: Princeton University Press
Release Date : 2020-03-24
The Cheating Cell written by Athena Aktipis and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with Medical categories.
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Cancer Ecosystems
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Author : Ubaldo E. Martinez-Outschoorn
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-27
Cancer Ecosystems written by Ubaldo E. Martinez-Outschoorn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-27 with categories.
The Emperor Of All Maladies
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Author : Siddhartha Mukherjee
language : en
Publisher: Simon and Schuster
Release Date : 2011-08-09
The Emperor Of All Maladies written by Siddhartha Mukherjee and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Health & Fitness categories.
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
The Ecological Theater And The Evolutionary Play
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Author : George Evelyn Hutchinson
language : en
Publisher: New Haven : Yale University Press
Release Date : 1965
The Ecological Theater And The Evolutionary Play written by George Evelyn Hutchinson and has been published by New Haven : Yale University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Biology categories.
In this delightful collection of essays, the author of The Enchanted Voyage and The Itinerant Ivory Tower turns his attention to the influence of environment on evolution. His discussion of the nature of the terrestrial environment we know leads to an account of possible ecological conditions on other bodies in the universe. Mr. Hutchinson also deals specifically with some influences on man's evolution, emphasizing the extremely recondite nature of these forces. One of the other pieces looks at the relationship of natural beauty to works of art, particularly in the context of comparisons between natural history museums and art galleries. The final essay, "The Cream in the Gooseberry Fool," is an entertaining account of an English country clergyman's work with the European magpie moth, which resulted in one of the most significant early discoveries in genetics. The treatment throughout requires no technical learning, though the most important and modern theoretical results are cited in the footnotes.
Explaining Cancer
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Author : Anya Plutynski
language : en
Publisher: Oxford University Press
Release Date : 2018-07-18
Explaining Cancer written by Anya Plutynski and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-18 with Science categories.
In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.
Veer Ecology
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Author : Jeffrey Jerome Cohen
language : en
Publisher: U of Minnesota Press
Release Date : 2017-12-15
Veer Ecology written by Jeffrey Jerome Cohen and has been published by U of Minnesota Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-15 with Philosophy categories.
The words most commonly associated with the environmental movement—save, recycle, reuse, protect, regulate, restore—describe what we can do to help the environment, but few suggest how we might transform ourselves to better navigate the sudden turns of the late Anthropocene. Which words can help us to veer conceptually along with drastic environmental flux? Jeffrey Jerome Cohen and Lowell Duckert asked thirty brilliant thinkers to each propose one verb that stresses the forceful potential of inquiry, weather, biomes, apprehensions, and desires to swerve and sheer. Each term is accompanied by a concise essay contextualizing its meaning in times of resource depletion, environmental degradation, and global climate change. Some verbs are closely tied to natural processes: compost, saturate, seep, rain, shade, sediment, vegetate, environ. Many are vaguely unsettling: drown, unmoor, obsolesce, power down, haunt. Others are enigmatic or counterintuitive: curl, globalize, commodify, ape, whirl. And while several verbs pertain to human affect and action—love, represent, behold, wait, try, attune, play, remember, decorate, tend, hope—a primary goal of Veer Ecology is to decenter the human. Indeed, each of the essays speaks to a heightened sense of possibility, awakening our imaginations and inviting us to think the world anew from radically different perspectives. A groundbreaking guide for the twenty-first century, Veer Ecology foregrounds the risks and potentialities of living on—and with—an alarmingly dynamic planet. Contributors: Stacy Alaimo, U of Texas at Arlington; Joseph Campana, Rice U; Holly Dugan, George Washington U; Lara Farina, West Virginia U; Cheryll Glotfelty, U of Nevada, Reno; Anne F. Harris, DePauw U; Tim Ingold, U of Aberdeen; Serenella Iovino, U of Turin; Stephanie LeMenager, U of Oregon; Scott Maisano, U of Massachusetts, Boston; Tobias Menely, U of California, Davis; Steve Mentz, St. John’s U; J. Allan Mitchell, U of Victoria; Timothy Morton, Rice U; Vin Nardizzi, U of British Columbia; Laura Ogden, Dartmouth College; Serpil Opperman, Hacettepe U, Ankara; Daniel C. Remein, U of Massachusetts, Boston; Margaret Ronda, U of California, Davis; Nicholas Royle, U of Sussex; Catriona Sandilands, York U; Christopher Schaberg, Loyola U; Rebecca R. Scott, U of Missouri; Theresa Shewry, U of California, Santa Barbara; Mick Smith, Queen’s U; Jesse Oak Taylor, U of Washington; Brian Thill, Golden West College; Coll Thrush, U of British Columbia, Vancouver; Cord J. Whitaker, Wellesley College; Julian Yates, U of Delaware.
Introduction To Mathematical Oncology
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Author : Yang Kuang
language : en
Publisher: CRC Press
Release Date : 2018-09-03
Introduction To Mathematical Oncology written by Yang Kuang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Mathematics categories.
Introduction to Mathematical Oncology presents biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of the models. They also develop new mathematical tools and look to future improvements on dynamical models. After introducing the general theory of medicine and exploring how mathematics can be essential in its understanding, the text describes well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. It continues the topic of avascular tumor growth in the context of partial differential equation models by incorporating the spatial structure and physiological structure, such as cell size. The book then focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. It also examines more mechanistically formulated models, including cell quota-based population growth models, with applications to real tumors and validation using clinical data. The remainder of the text presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts. Extensively classroom-tested in undergraduate and graduate courses, this self-contained book allows instructors to emphasize specific topics relevant to clinical cancer biology and treatment. It can be used in a variety of ways, including a single-semester undergraduate course, a more ambitious graduate course, or a full-year sequence on mathematical oncology.