The Role Of Chemoattractants In The Tumor Microenvironment
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The Role Of Chemoattractants In The Tumor Microenvironment
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Author : Giovanni Bernardini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-27
The Role Of Chemoattractants In The Tumor Microenvironment written by Giovanni Bernardini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-27 with categories.
Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2020-02-14
Tumor Microenvironment written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-14 with Science categories.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part A updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking a comprehensive update on research in the tumor microenvironment.
Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2021-07-21
Tumor Microenvironment written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-21 with Medical categories.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis.Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part B updates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher:
Release Date : 2021
Tumor Microenvironment written by Alexander Birbrair and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines - Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
Cancer Drug Delivery Systems Based On The Tumor Microenvironment
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Author : Yasuhiro Matsumura
language : en
Publisher: Springer Nature
Release Date : 2020-01-07
Cancer Drug Delivery Systems Based On The Tumor Microenvironment written by Yasuhiro Matsumura and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Medical categories.
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
The Role Of The Tumor Microenvironment In Modulating The Behavior Of Cancer Cells
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Author : Doctor Liron Berger
language : en
Publisher:
Release Date : 2014
The Role Of The Tumor Microenvironment In Modulating The Behavior Of Cancer Cells written by Doctor Liron Berger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Tumor Microenvironment
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Author :
language : en
Publisher:
Release Date : 2020
Tumor Microenvironment written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Cancer categories.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines - Part A updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking a comprehensive update on research in the tumor microenvironment. --
Tumor Microenvironment Regulation Of Tumor Expansion
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Author : Domenico Ribatti
language : en
Publisher: Academic Press
Release Date : 2021-04-04
Tumor Microenvironment Regulation Of Tumor Expansion written by Domenico Ribatti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-04 with Science categories.
Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs. Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment
Defining The Role Of Neutrophil Subsets In Breast Cancer Liver Metastases
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Author : Brian Hsu
language : en
Publisher:
Release Date : 2019
Defining The Role Of Neutrophil Subsets In Breast Cancer Liver Metastases written by Brian Hsu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
"Breast cancer is the most common cancer diagnosed among women and the emergence of metastatic breast cancer, the most advanced stage of the disease, is largely incurable. Upon dissemination from the primary tumor, breast cancer spreads primarily to the bone, lung, liver and brain. The liver represents a site of metastasis with poor prognosis and low survival rates. Despite its clinical relevance, little is known regarding the cellular and molecular mechanisms promoting breast cancer metastasis to the liver. We have recently identified that neutrophils, which account for the majority of circulating leukocytes and are typically the first responders at the site of inflammation, have been implicated in promoting breast cancer liver metastasis. The work presented in this thesis is focused on identifying the role of pro-metastatic neutrophils and how they are generated, recruited to the tumor microenvironment and promote the growth of liver metastases. Using well-characterized breast cancer cell lines with different metastatic potential to the lung or the liver, we identified G-CSF, as an important cytokine that is required, but not sufficient, to promote the mobilization of immature low density neutrophils (LDNs) in breast cancer liver metastasis. We show that circulating immature LDNs promote the growth of liver metastasis whereas mature high-density neutrophils (HDNs) were anti-metastatic. Additionally, immature LDNs display increased metabolic flexibility, which facilitates their ability to undergo NETosis (neutrophil extracellular traps) under glucose-deprivation and contribute to the establishment and growth of liver metastases.To investigate the ability of the neutrophil subpopulations to migrate to the liver microenvironment, we utilized both in vitro and in vivo experiments to demonstrate that immature LDNs preferentially infiltrate the liver microenvironment due to tumor-derived chemoattractants. Using shRNA-mediated approaches and pharmacological inhibitors, we show that C3a is a novel chemoattractant that preferentially promotes the recruitment of immature LDNs, with no effect on HDN recruitment.Finally, to determine the role of neutrophils in mediating the growth of liver metastases, we used various immunocompromised mice to determine whether additional immune cells are impacted by pro-metastatic neutrophil functions. We show that immature low-density neutrophils mediate immune suppression of NK-cells, but not T-cells, through the neutrophil-specific expression of CD155. CD155 interacts with an inhibitory receptor, TIGIT, expressed on NK cells, thereby inhibiting NK-mediated tumor cell clearance.Altogether, the body of thesis demonstrates that immature LDNs, a subset of neutrophils that are enriched in mice and humans during cancer progression, are pro-metastatic and have unique mechanisms to migrate to the tumor microenvironment and promote immune suppression"--
The Heterogeneity Of Cancer Metabolism
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Author : Anne Le
language : en
Publisher: Springer
Release Date : 2018-06-26
The Heterogeneity Of Cancer Metabolism written by Anne Le and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Medical categories.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.