The Role Of The Tumor Microenvironment In Modulating The Behavior Of Cancer Cells
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The Role Of The Tumor Microenvironment In Modulating The Behavior Of Cancer Cells
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Author : Doctor Liron Berger
language : en
Publisher:
Release Date : 2014
The Role Of The Tumor Microenvironment In Modulating The Behavior Of Cancer Cells written by Doctor Liron Berger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The Extracellular Matrix And The Tumor Microenvironment
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Author : Ilona Kovalszky
language : en
Publisher: Springer Nature
Release Date : 2022-07-06
The Extracellular Matrix And The Tumor Microenvironment written by Ilona Kovalszky and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-06 with Medical categories.
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Analyzing The Role Of The Mammary Tumor Microenvironment In The Pro Angiogenic Behavior Of Adipose Derived Stem Cells
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Author : Young Hye Song
language : en
Publisher:
Release Date : 2016
Analyzing The Role Of The Mammary Tumor Microenvironment In The Pro Angiogenic Behavior Of Adipose Derived Stem Cells written by Young Hye Song and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Breast cancer is the leading cause of death of women worldwide, yet the cure for the disease remains elusive. Current therapies directly targeting cancer cells have been limited in effectiveness, partly due to increasing evidence suggesting that host stroma also plays a critical role in disease progression. Hence, studies increasingly focus on gaining a better understanding of the cellular and molecular mechanisms underlying cancer-stroma interactions. In breast cancer in particular, adipose-derived stem cells (ASCs) function as tissue-resident stromal cells that modulate the mammary microenvironment and thus, tumor progression. However, knowledge of the functional contributions of ASCs to tumor progression is relatively limited. Of importance is the effect of ASCs on tumor angiogenesis, or sprouting of new blood vessels by endothelial cells (ECs) in a tumor, a hallmark of cancer that renders tumors less susceptible to therapeutics. A majority of studies that discuss pro-angiogenic behavior of ASCs focuses on their pro-angiogenic factor secretion while cultured on a 2-D plastic substrate. However, this fails to fully recapitulate their behavior in the human body where 3-D heterotypic cell-matrix and cell-cell interactions occur. Additionally, host stromal cells in the tumor microenvironment such as ASCs have been shown to differentiate into myofibroblastic cells that remodel the surrounding extracellular matrix (ECM) extensively, which further promotes tumor progression, iii for example, via increased secretion of growth factors, enhancing cancer cell invasion, and promoting angiogenesis. Equally important are the microenvironmental factors that modulate stromal cell behavior. Of particular interest are tumor-secreted factors, such as tumor cell-derived extracellular vesicles (TEVs), and hypoxia. TEVs were once thought to be debris, but they are now understood to contain myriad bioactive signaling molecules and to transform normal host stromal cells into tumorassociated ones, such as myofibroblasts. Additionally, hypoxia, or low oxygen tension, exists at the core of the tumor and is a critical regulator of tumor angiogenesis. However, it is unclear how extended ECM remodeling, TEVs, and hypoxia modulate myofibroblastic and pro-angiogenic behavior of ASCs in the mammary tumor microenvironment. To investigate the aforementioned question, ASCs were cultured in type I collagen hydrogel-based 3-D culture systems to investigate the following aspects: 1) the effect of extended ECM remodeling by ASCs on angiogenesis by ECs, 2) the effect of TEVs on myofibroblastic differentiation of ASCs and the resulting consequences on angiogenesis, and 3) the effect of tumorsecreted factors and hypoxia on myofibroblastic and pro-angiogenic behavior of ASCs. The results presented here indicate that prolonged ECM remodeling by ASCs as well as exposure of ASCs to TEVs and hypoxia increase pro-angiogenic behavior of ASCs and subsequent endothelial sprouting. On the other hand, hypoxia prevents myofibroblastic differentiation of ASCs whereas prolonged TEV treatment promotes it. My work suggests that ASCs are an integral cellular modulator of the tumor microenvironment and that host stromal cells should be taken into consideration when designing therapeutic targets against breast cancer. iv.
Tumor Microenvironment
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Author : Jacinta Serpa
language : en
Publisher: Springer Nature
Release Date : 2020-03-04
Tumor Microenvironment written by Jacinta Serpa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Medical categories.
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response
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Author : Petranel T. Ferrao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response written by Petranel T. Ferrao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
Cancer Microenvironment And Therapeutic Implications
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Author : Gianfranco Baronzio
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-10
Cancer Microenvironment And Therapeutic Implications written by Gianfranco Baronzio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-10 with Medical categories.
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
Systems Biology Of Tumor Microenvironment
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Author : Katarzyna A. Rejniak
language : en
Publisher: Springer
Release Date : 2016-10-13
Systems Biology Of Tumor Microenvironment written by Katarzyna A. Rejniak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-13 with Medical categories.
This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
The Role Of Chemoattractants In The Tumor Microenvironment
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Author : Giovanni Bernardini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-27
The Role Of Chemoattractants In The Tumor Microenvironment written by Giovanni Bernardini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-27 with categories.
The Tumor Microenvironment
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Author : Rebecca G. Bagley
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-02
The Tumor Microenvironment written by Rebecca G. Bagley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-02 with Medical categories.
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
Tumor Microenvironment
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Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2021-07-21
Tumor Microenvironment written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-21 with Medical categories.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis.Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part B updates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.