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Data Management Of Protein Interaction Networks


Data Management Of Protein Interaction Networks
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Data Management Of Protein Interaction Networks


Data Management Of Protein Interaction Networks
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Author : Mario Cannataro
language : en
Publisher: John Wiley & Sons
Release Date : 2012-02-03

Data Management Of Protein Interaction Networks written by Mario Cannataro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-03 with Computers categories.


Current PPI databases do not offer sophisticated querying interfaces and especially do not integrate existing information about proteins. Current algorithms for PIN analysis use only topological information, while emerging approaches attempt to exploit the biological knowledge related to proteins and kinds of interaction, e.g. protein function, localization, structure, described in Gene Ontology or PDB. The book discusses technologies, standards and databases for, respectively, generating, representing and storing PPI data. It also describes main algorithms and tools for the analysis, comparison and knowledge extraction from PINs. Moreover, some case studies and applications of PINs are also discussed.



Protein Protein And Domain Domain Interactions


Protein Protein And Domain Domain Interactions
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Author : Pandjassarame Kangueane
language : en
Publisher: Springer
Release Date : 2018-02-16

Protein Protein And Domain Domain Interactions written by Pandjassarame Kangueane and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-16 with Medical categories.


This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.



Biological Data Mining In Protein Interaction Networks


Biological Data Mining In Protein Interaction Networks
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Author : Li, Xiao-Li
language : en
Publisher: IGI Global
Release Date : 2009-05-31

Biological Data Mining In Protein Interaction Networks written by Li, Xiao-Li and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-31 with Technology & Engineering categories.


"The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.



Evolutionary Computation In Gene Regulatory Network Research


Evolutionary Computation In Gene Regulatory Network Research
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Author : Hitoshi Iba
language : en
Publisher: John Wiley & Sons
Release Date : 2016-02-23

Evolutionary Computation In Gene Regulatory Network Research written by Hitoshi Iba and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Computers categories.


Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.



Scientific And Statistical Database Management


Scientific And Statistical Database Management
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Author : Michael Gertz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-17

Scientific And Statistical Database Management written by Michael Gertz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-17 with Computers categories.


This book constitutes the proceedings of the 22nd International Conference on Scientific and Statistical Database Management, SSDBM 2010, held in Heidelberg, Germany in June/July 2010. The 30 long and 11 short papers presented were carefully reviewed and selected from 94 submissions. The topics covered are query processing; scientific data management and analysis; data mining; indexes and data representation; scientific workflow and provenance; and data stream processing.



Higher Plants Algae And Cyanobacteria In Space Environments


Higher Plants Algae And Cyanobacteria In Space Environments
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Author : Carmen Arena
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-15

Higher Plants Algae And Cyanobacteria In Space Environments written by Carmen Arena and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-15 with Science categories.




Protein Interaction Networks


Protein Interaction Networks
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Author : Aidong Zhang
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-06

Protein Interaction Networks written by Aidong Zhang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-06 with Computers categories.


The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.



Integrative Omics


Integrative Omics
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Author : Manish Kumar Gupta
language : en
Publisher: Elsevier
Release Date : 2024-05-03

Integrative Omics written by Manish Kumar Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.


Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways



Protein Protein Interactions


Protein Protein Interactions
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Author : Shahid Mukhtar
language : en
Publisher: Springer Nature
Release Date : 2023-07-14

Protein Protein Interactions written by Shahid Mukhtar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-14 with Science categories.


This detailed volume provides a comprehensive collection of classic and cutting-edge methods and techniques in mapping protein-protein interactions. The chapters include a variety of in vitro and in vivo experimental methods covering cell biology, biochemistry, and biophysics. In addition, the book also explores in silico methods including sequence-, structure-, and phylogenetic profile-based approaches as well as gene expression and machine learning methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein-Protein Interactions: Methods and Protocols serves as an ideal guide for researchers working in protein science and beyond.



Analyzing Network Data In Biology And Medicine


Analyzing Network Data In Biology And Medicine
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Author : Nataša Pržulj
language : en
Publisher: Cambridge University Press
Release Date : 2019-03-28

Analyzing Network Data In Biology And Medicine written by Nataša Pržulj and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-28 with Language Arts & Disciplines categories.


Introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, using real-world biological and medical examples.