Database Annotation In Molecular Biology

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Database Annotation In Molecular Biology

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Author : Arthur M. Lesk
language : en
Publisher: John Wiley & Sons
Release Date : 2005-09-01

Database Annotation In Molecular Biology written by Arthur M. Lesk and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-01 with Medical categories.

Two factors dominate current molecular biology: the amount of raw data is increasing very rapidly and successful applications in biomedical research require carefully curated and annotated databases. The quality of the experimental data -- especially nucleic acid sequences -- is satisfactory; however, annotations depend on features inferred from the data rather than measured directly, for instance the identification of genes in genome sequences. It is essential that these inferences are as accurate as possible and this requires human intervention. With the recognition of the importance of accurate database annotation and the requirement for individuals with particular constellations of skills to carry it out, annotators are emerging as specialists within the profession of bioinformatics. This book compiles information about annotation -- its current status, what is required to improve it, what skills must be brought to bear on database curation and hence what is the proper training for annotators. The book should be essential reading for all people working on biological databases, both biologists and computer scientists. It will also be of interest to all users of such databases, including molecular biologists, geneticists, protein chemists, clinicians and drug developers.

Bioinformatics Database Systems

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Author : Kevin Byron
language : en
Publisher: CRC Press
Release Date : 2016-12-19

Bioinformatics Database Systems written by Kevin Byron and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Computers categories.

Modern biological databases comprise not only data, but also sophisticated query facilities and bioinformatics data analysis tools. This book provides an exploration through the world of Bioinformatics Database Systems. The book summarizes the popular and innovative bioinformatics repositories currently available, including popular primary genetic and protein sequence databases, phylogenetic databases, structure and pathway databases, microarray databases and boutique databases. It also explores the data quality and information integration issues currently involved with managing bioinformatics databases, including data quality issues that have been observed, and efforts in the data cleaning field. Biological data integration issues are also covered in-depth, and the book demonstrates how data integration can create new repositories to address the needs of the biological communities. It also presents typical data integration architectures employed in current bioinformatics databases. The latter part of the book covers biological data mining and biological data processing approaches using cloud-based technologies. General data mining approaches are discussed, as well as specific data mining methodologies that have been successfully deployed in biological data mining applications. Two biological data mining case studies are also included to illustrate how data, query, and analysis methods are integrated into user-friendly systems. Aimed at researchers and developers of bioinformatics database systems, the book is also useful as a supplementary textbook for a one-semester upper-level undergraduate course, or an introductory graduate bioinformatics course.

Biomolecular Networks

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Author : Luonan Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2009-06-29

Biomolecular Networks written by Luonan Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with Computers categories.

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.

Introduction To Bio Ontologies

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Author : Peter N. Robinson
language : en
Publisher: CRC Press
Release Date : 2011-06-22

Introduction To Bio Ontologies written by Peter N. Robinson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-22 with Computers categories.

Introduction to Bio-Ontologies explores the computational background of ontologies. Emphasizing computational and algorithmic issues surrounding bio-ontologies, this self-contained text helps readers understand ontological algorithms and their applications.The first part of the book defines ontology and bio-ontologies. It also explains the importan

Biotechnology And Bioinformatics

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Author : Devarajan Thangadurai
language : en
Publisher: CRC Press
Release Date : 2014-07-01

Biotechnology And Bioinformatics written by Devarajan Thangadurai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-01 with Mathematics categories.

Reflecting the interdisciplinary nature of biotechnology, this book covers the role of targeted delivery of polymeric nanodrugs to cancer cells, microbial detoxifying enzymes in bioremediation and bacterial plasmids in antimicrobial resistance. It addresses modern trends such as pharmacogenomics, evaluation of gene expression, recombinant proteins from methylotrophic yeast, identification of novel fermentation inhibitors of bioethanol production, and polyhydroxyalkanoate based biomaterials. The book highlights the practical utility of biotechnology and bioinformatics for bioenergy, production of high value biochemicals, modeling molecular interactions, drug discovery, and personalized medicine.

Bioinformatics And Computational Biology

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Author : Basant K. Tiwary
language : en
Publisher: Springer Nature
Release Date : 2021-11-23

Bioinformatics And Computational Biology written by Basant K. Tiwary and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-23 with Medical categories.

This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Advances In Database Technology Edbt 2004

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Author : Elisa Bertino
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-02-25

Advances In Database Technology Edbt 2004 written by Elisa Bertino and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-25 with Business & Economics categories.

This book constitutes the refereed proceedings of the 9th International Conference on Extending Database Technology, EDBT 2004, held in Heraklion, Crete, Greece, in March 2004. The 42 revised full papers presented together with 2 industrial application papers, 15 software demos, and 3 invited contributions were carefully reviewed and selected from 294 submissions. The papers are organized in topical sections on distributed, mobile and peer-to-peer database systems; data mining and knowledge discovery; trustworthy database systems; innovative query processing techniques for XML data; data and information on the web; query processing techniques for spatial databases; foundations of query processing; advanced query processing and optimization; query processing techniques for data and schemas; multimedia and quality-aware systems; indexing techniques; and imprecise sequence pattern queries.

Encyclopedia Of Bioinformatics And Computational Biology

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Author :
language : en
Publisher: Elsevier
Release Date : 2018-08-21

Encyclopedia Of Bioinformatics And Computational Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Data Mining In Drug Discovery

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Author : Rémy D. Hoffmann
language : en
Publisher: John Wiley & Sons
Release Date : 2013-09-25

Data Mining In Drug Discovery written by Rémy D. Hoffmann and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-25 with Medical categories.

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project.

Advances In Web Age Information Management

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Author : Xiaofeng Meng
language : en
Publisher: Springer
Release Date : 2003-08-02

Advances In Web Age Information Management written by Xiaofeng Meng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-02 with Computers categories.

This book constitutes the refereed proceedings of the Third International Conference on Web-Age Information Management, WAIM 2002 held in Beijing, China in August 2002. The 40 papers presented together with two system demonstrations were carefully reviewed and selected from 169 submissions. The papers are organized in topical sections on XML; spatio-temporal databases; data mining and learning; XML and web; workflows and e-services; bio informatics, views, and OLAP; clustering and high-dimensional data; web search; optimization and updates; and transactions and multimedia.