Decoding Dna Methylation

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Decoding Dna Methylation

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Author : Dr. Sivakumar Vijayaraghavalu
language : en
Publisher: OrangeBooks Publication
Release Date : 2025-02-23

Decoding Dna Methylation written by Dr. Sivakumar Vijayaraghavalu and has been published by OrangeBooks Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-23 with Science categories.

“Decoding DNA Methylation” explores the pivotal role of DNA methylation in gene regulation, genome stability and diseases. This book bridges fundamental biology with clinical applications by covering key mechanisms, including DNA methyltransferases, methylation dynamics, and their interplay with histone modifications. It examines methylation’s impact on cancer, neurological disorders and epigenetic inheritance, highlighting emerging biomarkers and therapeutic strategies. With insights into environmental influences and precision medicine, this book serves as a resource for researchers, clinicians, and students seeking to understand epigenetics in health and disease.

Personalized Epigenetics

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Author : Trygve Tollefsbol
language : en
Publisher: Elsevier
Release Date : 2024-07-17

Personalized Epigenetics written by Trygve Tollefsbol and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-17 with Science categories.

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. - Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders - Covers key methodological processes that are important in personalized medicine - Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area - Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

Epigenomics In Health And Disease

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Author : Mario Fraga
language : en
Publisher: Academic Press
Release Date : 2015-10-12

Epigenomics In Health And Disease written by Mario Fraga and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-12 with Science categories.

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. - Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential - Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis - Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Epigenetics Methods

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Author : Trygve O. Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2020-07-08

Epigenetics Methods written by Trygve O. Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Medical categories.

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. - Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application - Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods - Written at verbal and technical levels that can be understood by scientists and students alike - Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Epigenetic Metabolic And Transcriptional Regulation Of Immune Cell Plasticity And Functions In Cancer And Non Cancer Diseases

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Author : Yun Dai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-25

Epigenetic Metabolic And Transcriptional Regulation Of Immune Cell Plasticity And Functions In Cancer And Non Cancer Diseases written by Yun Dai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-25 with Medical categories.

Multi Omics Approaches For Decoding Heterogeneity In Cancer Immunotherapy

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Author : Lin Qi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-22

Multi Omics Approaches For Decoding Heterogeneity In Cancer Immunotherapy written by Lin Qi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-22 with Science categories.

Epigenetic Technological Applications

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Author : Yujun George Zheng
language : en
Publisher: Academic Press
Release Date : 2015-05-30

Epigenetic Technological Applications written by Yujun George Zheng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-30 with Science categories.

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. - Discusses technologies that are critical for epigenetic research and application - Includes epigenetic applications for state-of-the-art technologies - Contains a global perspective on the future of epigenetics

Epigenomics

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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2012-08-02

Epigenomics written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-02 with Science categories.

Understanding mechanisms of gene regulation that are independent of the DNA sequence itself - epigenetics - has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.

Translating Epigenetics To The Clinic

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Author : Jeffrey Laurence
language : en
Publisher: Academic Press
Release Date : 2016-12-30

Translating Epigenetics To The Clinic written by Jeffrey Laurence and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-30 with Science categories.

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the 'diseases of modernity'—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole. - Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic - Features extensive pedagogical updates aiming to improve the education of translational researchers in this field - Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

Microarray Innovations

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Author : Gary Hardiman
language : en
Publisher: CRC Press
Release Date : 2009-04-02

Microarray Innovations written by Gary Hardiman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-02 with Medical categories.

In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr