Dermatological Drug Development
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Dermatological Drug Development
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Author : Tomoko Maeda-Chubachi
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2020-09-18
Dermatological Drug Development written by Tomoko Maeda-Chubachi and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-18 with Medical categories.
This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the complexities of dermatological drug development, covering topical, oral, and biologic drugs. This book fills an important gap, as there is currently no other textbook addressing dermatological drug development, explaining and illustrating why unique nonclinical and clinical studies are necessary and how they are typically designed and conducted. The drug development process is also an evolving strategy that is characterized by communicating, negotiating, and agreeing with regulatory agencies, such as FDA (US), EMA (EU), and PMDA (Japan).
Dermal Drug Selection And Development
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Author : Lionel Trottet
language : en
Publisher: Springer
Release Date : 2017-08-07
Dermal Drug Selection And Development written by Lionel Trottet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-07 with Medical categories.
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
Food And Drug Administration S Role In Dermatology An Issue Of Dermatologic Clinics E Book
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Author : Markham C. Luke
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-06-24
Food And Drug Administration S Role In Dermatology An Issue Of Dermatologic Clinics E Book written by Markham C. Luke and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.
In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
Clinical Dermatology Trials 101
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Author : Adnan Nasir
language : en
Publisher: Springer
Release Date : 2014-11-12
Clinical Dermatology Trials 101 written by Adnan Nasir and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-12 with Medical categories.
Clinical Dermatology Trials 101 provides dermatologists with a handbook that allows them to become familiar with all aspects of clinical trials. Everything from obtaining the necessary tools and equipment, complying with local, federal, and international guidelines and regulations, and hiring and training staff for the safe and up-to-date conduct of dermatology clinical trials is covered. Written by leading experts in the field, Clinical Dermatology Trials 101 is the only clinical trial how-to available for dermatologists. With skin disease affecting nearly seventy percent of the population over a lifetime, and the rate of development of new drugs and devices for dermatologic use increasing at an exponential rate, there is a tremendous need for training and developing dermatology clinical research facilities to expedite the translation of basic and applied research, from bench to bedside. This is useful for practicing dermatologists, academic dermatologists, dermatology residents, clinical research fellows, dermatology fellows, research scientists, industry dermatologists, and medical students.
Drug Repurposing In Dermatology
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Author : Farid A. Badria
language : en
Publisher:
Release Date : 2020
Drug Repurposing In Dermatology written by Farid A. Badria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Medical categories.
The withdrawal of several blockbuster drugs due to severe adverse effects and the failure of several developed drugs in clinical trials raised questions about the efficacy of current approaches of drug discovery. Moreover, the limitation of resources and the long and costive process of drug discovery made a lot of pharmaceutical companies to employ drug repurposing strategies to get new insights about activities that were not considered during their initial discovery. The development of therapeutics for treatment of dermatological condition is not considered as priority although it affects the lifestyle of thousands of people around the world. Serendipity and observations have contributed significantly in this field but immerse efforts have been exerted to find systematic methods to identify new indications for drugs, especially with the unprecedented progress in molecular biology and omics. So, in this chapter, we will emphasize on different approaches used for drug repositioning and how it was applied to find new therapeutics for different dermatoses.
Systemic Drug Treatment In Dermatology
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Author : Sarah H. Wakelin
language : en
Publisher: CRC Press
Release Date : 2002-06-01
Systemic Drug Treatment In Dermatology written by Sarah H. Wakelin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-06-01 with Medical categories.
There has been an increase in the use of systemic drug therapy for skin diseases during recent years. This reflects advances in drug development but many are potent drugs which can have serious or life threatening adverse effects. Aimed at dermatologists and general practitioners, this book provides an accessible and concise aid to prescribing and
Handbook Of Systemic Drug Treatment In Dermatology
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Author : Sarah H. Wakelin
language : en
Publisher: Thieme
Release Date : 2004
Handbook Of Systemic Drug Treatment In Dermatology written by Sarah H. Wakelin and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Dermatopharmacology categories.
Recent increases in the use of systemic drug therapy for skin diseases reflects advances in drug development but many are potent drugs which can have serious or life threatening adverse effects. Aimed at dermatologists, primary care physicians, pharmacists and specialist nurses this book provides an accessible and concise aid to prescribing and monitoring systemic dermatologic therapy. Evidence based data or established guidelines have been included where possible. Common and important adverse drug effects and their management are covered along with some of the recent advances in drug treatment and monitoring of patients. Monitoring information in each chapter appears in tabular format for easy accessibility. Cautionary tables are color coded (green, yellow, red) for instant recognition of safety profiles. Key Features: Easy to use pocket sized reference guide with color for headings/charts and tables Coverage for each drug includes: dermatologic uses, presentation, dosages, monitoring, contraindications, adverse effects, references and further reading. Risks to vulnerable patient groups are assessed.
Topical And Transdermal Drug Delivery
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Author : Heather A. E. Benson
language : en
Publisher: John Wiley & Sons
Release Date : 2012-02-03
Topical And Transdermal Drug Delivery written by Heather A. E. Benson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-03 with Medical categories.
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.
Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions
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Author : Neil H. Shear
language : en
Publisher: Springer
Release Date : 2018-10-19
Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions written by Neil H. Shear and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-19 with Medical categories.
This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development. The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.
The Art And Science Of Dermal Formulation Development
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Author : Marc B. Brown
language : en
Publisher: CRC Press
Release Date : 2019-03-01
The Art And Science Of Dermal Formulation Development written by Marc B. Brown and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-01 with Medical categories.
The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes