Design Of Experiments And Advanced Statistical Techniques In Clinical Research
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Design Of Experiments And Advanced Statistical Techniques In Clinical Research
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Author : Basavarajaiah D. M.
language : en
Publisher: Springer Nature
Release Date : 2020-11-05
Design Of Experiments And Advanced Statistical Techniques In Clinical Research written by Basavarajaiah D. M. and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-05 with Medical categories.
Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
Advanced Statistical Methods In Life Science
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Author : Basavarajaiah D.M
language : en
Publisher: CRC Press
Release Date : 2025-07-25
Advanced Statistical Methods In Life Science written by Basavarajaiah D.M and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-25 with Mathematics categories.
This book introduces the principles and foundations of advanced statistical methods for designing experiments and testing hypotheses in life sciences. Advanced statistical methods, such as testing of hypotheses, recent methods of sample size determination/imputation, estimation techniques, probability distributions, and univariate analysis demonstrated with real data, and their integration into life sciences are included in this book. Advanced topics are presented with sufficient conceptual depth and examples to explain the use of recent statistical techniques and to demonstrate what conclusions can be drawn at the right time using modeling in life science research. Key features: Explains the derivation of statistical models to prove disease transmission using massive real-world datasets to explore practical applicability Incorporates the application of innovative advanced statistical and epidemiological models and demonstrates the possible solutions for public health policy intervention Helps to understand the process of hypothesis testing in small or larger observations by using weighted parameters Presents suitable examples and real-life research datasets, and all models can easily be followed in formulating statistical and mathematical derivations and key points Includes machine learning (ML), statistical methods for meta-analysis, testing of hypotheses, methods of imputation, estimation techniques, probability distributions, univariate analysis, and recent nonparametric methods, all illustrated through actual data This textbook is for students and scholars of various courses in life sciences, medicine, mathematics, and statistical science. It will also help academicians and researchers to understand the foundation of this topic.
Introduction To Statistical Methods Design Of Experiments And Statistical Quality Control
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Author : Dharmaraja Selvamuthu
language : en
Publisher: Springer
Release Date : 2018-09-03
Introduction To Statistical Methods Design Of Experiments And Statistical Quality Control written by Dharmaraja Selvamuthu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Mathematics categories.
This book provides an accessible presentation of concepts from probability theory, statistical methods, the design of experiments and statistical quality control. It is shaped by the experience of the two teachers teaching statistical methods and concepts to engineering students, over a decade. Practical examples and end-of-chapter exercises are the highlights of the text as they are purposely selected from different fields. Statistical principles discussed in the book have great relevance in several disciplines like economics, commerce, engineering, medicine, health-care, agriculture, biochemistry, and textiles to mention a few. A large number of students with varied disciplinary backgrounds need a course in basics of statistics, the design of experiments and statistical quality control at an introductory level to pursue their discipline of interest. No previous knowledge of probability or statistics is assumed, but an understanding of calculus is a prerequisite. The whole book serves as a master level introductory course in all the three topics, as required in textile engineering or industrial engineering. Organised into 10 chapters, the book discusses three different courses namely statistics, the design of experiments and quality control. Chapter 1 is the introductory chapter which describes the importance of statistical methods, the design of experiments and statistical quality control. Chapters 2–6 deal with statistical methods including basic concepts of probability theory, descriptive statistics, statistical inference, statistical test of hypothesis and analysis of correlation and regression. Chapters 7–9 deal with the design of experiments including factorial designs and response surface methodology, and Chap. 10 deals with statistical quality control.
Advanced Statistical Methods In Data Science
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Author : Ding-Geng Chen
language : en
Publisher: Springer
Release Date : 2016-11-30
Advanced Statistical Methods In Data Science written by Ding-Geng Chen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-30 with Mathematics categories.
This book gathers invited presentations from the 2nd Symposium of the ICSA- CANADA Chapter held at the University of Calgary from August 4-6, 2015. The aim of this Symposium was to promote advanced statistical methods in big-data sciences and to allow researchers to exchange ideas on statistics and data science and to embraces the challenges and opportunities of statistics and data science in the modern world. It addresses diverse themes in advanced statistical analysis in big-data sciences, including methods for administrative data analysis, survival data analysis, missing data analysis, high-dimensional and genetic data analysis, longitudinal and functional data analysis, the design and analysis of studies with response-dependent and multi-phase designs, time series and robust statistics, statistical inference based on likelihood, empirical likelihood and estimating functions. The editorial group selected 14 high-quality presentations from this successful symposium and invited the presenters to prepare a full chapter for this book in order to disseminate the findings and promote further research collaborations in this area. This timely book offers new methods that impact advanced statistical model development in big-data sciences.
Small Clinical Trials
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2001-02-01
Small Clinical Trials written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-01 with Medical categories.
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Advanced Medical Statistics 2nd Edition
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Author : Ying Lu
language : en
Publisher: World Scientific
Release Date : 2015-06-29
Advanced Medical Statistics 2nd Edition written by Ying Lu and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-29 with Medical categories.
The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch.The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field.Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research.
Covid Transmission Modeling
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Author : DM Basavarajaiah
language : en
Publisher: CRC Press
Release Date : 2022-06-28
Covid Transmission Modeling written by DM Basavarajaiah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-28 with Mathematics categories.
COVID Transmission Modeling: An Insight into Infectious Diseases Mechanism provides an interdisciplinary overview of the COVID-19 pandemic crisis and covers various aspects of newer modeling techniques and practical solutions for health emergencies. This book aims to formulate various innovative and pragmatic mathematical, statistical, and epidemiological models using COVID-19 real data sets. It emphasizes interdisciplinary theoretical postulates derived from practical insights and knowledge of public health. Each of the book’s 12 chapters provides invaluable and exploratory tools to enable explicit assumptions, highlights key health indicators, and determines the geometric progression and control measures of the disease. The present developed models will allow readers to extrapolate the exact reason for the outbreak and pave the way for scientific information on vaccine trials and socioeconomic, psychological, and disease burden worldwide. These advanced techniques of modeling and their applications are in greater need than ever for effective connection between mathematicians, statisticians, epidemiologists, researchers, clinicians, and policymakers for making appropriate decisions at the right time. With the advent of emerging health science, all models are demonstrated with real-life data sets and provided with illustrations and eye-catching graphs and diagrams so that the readers can easily understand the concept of COVID-19 pandemic interventions and their control measures, and their impact. Features Addresses all aspects of mitigation/control measures, estimation of transmission rate, economic impact assessment, genetic complexity of COVID-19, herd immunity, and various methods, including newer mathematical, statistical, and epidemiological models in the analysis of COVID-19 pandemic outbreak Covers the application of innovative, advanced statistical and epidemiological models and demonstrates possible solutions toward supportive treatment aspects of COVID-19 and its control measures Includes models that can easily be followed in formulating the mathematical derivations and key points Supplemented with ample illustrations, images, diagrams, and figures This book is aimed at postgraduate students studying medicine and healthcare, mathematics, and statistical information. Researchers will also find this book very helpful.
Statistical Analysis Of Designed Experiments
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Author : Helge Toutenburg
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-05-09
Statistical Analysis Of Designed Experiments written by Helge Toutenburg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-09 with Mathematics categories.
Unique in commencing with relatively simple statistical concepts and ideas found in most introductory statistical textbooks, this book goes on to cover more material useful for undergraduates and graduate in statistics and biostatistics.
Advanced Performance Improvement In Health Care
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Author : Donald Lighter
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2011
Advanced Performance Improvement In Health Care written by Donald Lighter and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Business & Economics categories.
Amidst a deepening crisis in U.S. health care, Advanced Performance Improvement in Health Care provides a results-oriented approach to rehabilitating an ailing healthcare system. With his innovative, instructive strategies, Lighter offers a welcome road map to guide meaningful change in the industry and to equip healthcare managers to meet 21st century challenges. Advanced Performance Improvement in Health Care: Principles and Methods provides healthcare educators, leaders, and clinicians with the specific knowledge and tools vital for creating and advocating for quality-centric, next-generation healthcare organizations. This unique compilation of management, analytical, and statistical methods and techniques serves as a comprehensive guide to harnessing todays technology and developing a culture of quality that delivers sustainable, quantifiable value in healthcare organizations.
Advanced Linear Models
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Author : Shein-Chung Chow
language : en
Publisher: Routledge
Release Date : 2018-05-04
Advanced Linear Models written by Shein-Chung Chow and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Mathematics categories.
This work details the statistical inference of linear models including parameter estimation, hypothesis testing, confidence intervals, and prediction. The authors discuss the application of statistical theories and methodologies to various linear models such as the linear regression model, the analysis of variance model, the analysis of covariance model, and the variance components model.