Design Of Hybrid Molecules For Drug Development
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Design Of Hybrid Molecules For Drug Development
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Author : Michael Decker
language : en
Publisher: Elsevier
Release Date : 2017-04-05
Design Of Hybrid Molecules For Drug Development written by Michael Decker and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Science categories.
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. - Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes - Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied - Compares the advantages and disadvantages of these compounds - Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Small Molecule Drug Discovery
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Author : Andrea Trabocchi
language : en
Publisher: Elsevier
Release Date : 2019-11-23
Small Molecule Drug Discovery written by Andrea Trabocchi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-23 with Science categories.
Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. - Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery - Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics - Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches - Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Identification Of Multiple Targets In The Fight Against Alzheimer S Disease
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Author : Patrizia Giannoni
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-31
Identification Of Multiple Targets In The Fight Against Alzheimer S Disease written by Patrizia Giannoni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with categories.
Advanced Concepts And Applications
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Author : Fidele Ntie-Kang
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-11-22
Advanced Concepts And Applications written by Fidele Ntie-Kang and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-22 with Science categories.
Vol. 2 of Chemoinformatics of Natural Products introduces the reader to the currently available tools for toxicity prediction, drug property prediction, an enumeration of compounds, scaffolds and functional groups in nature, computational methods for lead identification, metabolite biosynthesis, etc. Selected case studies and hands-on tutorial exercises have been included.
Polypharmacology
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Author : Zhiguo Wang
language : en
Publisher: Springer Nature
Release Date : 2022-08-01
Polypharmacology written by Zhiguo Wang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-01 with Medical categories.
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.
Issues In Medical Chemistry 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-01-10
Issues In Medical Chemistry 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-10 with Medical categories.
Issues in Medical Chemistry / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Medicinal Chemistry. The editors have built Issues in Medical Chemistry: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medicinal Chemistry in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Medical Chemistry: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Drug Discovery In Cancer Epigenetics
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Author : Gerda Egger
language : en
Publisher: Academic Press
Release Date : 2015-11-19
Drug Discovery In Cancer Epigenetics written by Gerda Egger and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-19 with Science categories.
Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. - Highlights the potential of epigenetic alterations in cancer for drug development - Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy - Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation
Phytomolecules As A Source For Drug Discovery
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Author : Harish C. Upadhyay
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2025-04-02
Phytomolecules As A Source For Drug Discovery written by Harish C. Upadhyay and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-02 with Medical categories.
This book provides a comprehensive knowledge of medicinal plants, phytomolecules, and their derivatives, playing a crucial role in the area of antimicrobials. By providing a comprehensive overview of the latest research and developments in phytochemistry and pharmacology, the book underscores the significance of medicinal plants as a rich and sustainable source of novel antimicrobial agents. The book is intended as a valuable resource for researchers, pharmacologists, and healthcare professionals seeking to develop effective and eco-friendly solutions to combat antibiotic resistance and emerging infectious diseases.
Antimicrobial Drug Discovery
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Author : G. Tegos
language : en
Publisher: CABI
Release Date : 2012
Antimicrobial Drug Discovery written by G. Tegos and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Anti-infective agents categories.
Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.
Advancement Of Phenolic Acids In Drug Discovery
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Author : Naresh Kumar
language : en
Publisher: Elsevier
Release Date : 2024-06-19
Advancement Of Phenolic Acids In Drug Discovery written by Naresh Kumar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-19 with Medical categories.
Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids. - Highlights fundamental concepts with advanced exploration of phenolic acids - Provides in-depth coverage on the design and development of novel drugs from natural phenolic acids - Reviews the changing role of phenolic acids