Detection Of Multiple Explosives By Surface Enhanced Raman Scattering

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Detection Of Multiple Explosives By Surface Enhanced Raman Scattering

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Author : Kirsty Milligan
language : en
Publisher:
Release Date : 2019

Detection Of Multiple Explosives By Surface Enhanced Raman Scattering written by Kirsty Milligan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.

Simultaneous Detection Of Multiple Explosives Using Surface Enhanced Raman Scattering

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Author : Rachel Norman
language : en
Publisher:
Release Date : 2016

Simultaneous Detection Of Multiple Explosives Using Surface Enhanced Raman Scattering written by Rachel Norman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

There remains a continuing threat of terrorist/insurgent attacks on military/civilian personnel and key strategic infrastructures both within the UK mainland and in operational theatres. The development of a novel, innovative, low cost, field deployable bionanosensor, which will have the capability to detect low levels of explosive in a multiplexed fashion is required. The use of the specific interaction between small molecules and biological capture molecules such as antibodies coupled with the detection technique of surface enhanced Raman scattering (SERS) allows a ‘one shot’ analysis.This research makes use of antibody functionalised silver nanoparticles for the detection of the explosives TNT, RDX and PETN by surface enhanced Raman scattering (SERS). Commercially available antibodies specific for TNT and RDX have been modified to specifically orientate ‘flat’ on the surface of silver nanoparticles bringing the target close enough to the metal surface to allow an intrinsic SERS signal of the target molecule to be obtained. Quantitative detection of TNT and RDX explosives was achieved, with pM sensitivity demonstrated for RDX. Furthermore, TNT was detected in two different types of dirt, natural and synthetic dirt in order to mimic a more realistic matrix in which TNT would be found in the field.However, for the detection of PETN, it was required to develop a method to modify a PETN antibody in-house, to specifically orientate ‘flat’ on the nanoparticles surface similarly to the commercially available antibodies. This was achieved by using carbodiimide chemistry and the antibody was purified by cartridge centrifugation and HPLC. The PETN modified antibody was then functionalised onto silver nanoparticles and detection of PETN was achieved by SERS. In addition, PCA was used to allow multiplexed analysis based on unique Raman bands for the three different explosives which could be clearly identified in the SERS spectra.Finally, TNT was detected by using magnetic nanoparticles which were functionalised with a terminal amine group in combination with FITC modified TNT antibody functionalised silver nanoparticles. This assay was designed to allow for the formation of a Meisenheimer complex in the presence of TNT, between the amine functionalised magnetic nanoparticles and the TNT. Furthermore, the TNT antibody functionalised silver nanoparticles also binds to TNT, aggregating the nanoparticles. The magnetic nanoparticles were subsequently used to remove the nanoparticle assembly from the matrix, resulting in a concentrated sample on the magnet, resulting in an increase in SERS.

Icol 2019

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Author : Kehar Singh
language : en
Publisher: Springer Nature
Release Date : 2021-03-01

Icol 2019 written by Kehar Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-01 with Science categories.

This book presents peer-reviewed articles from the International Conference on Optics and Electro-optics, ICOL-2019, held at Dehradun in India. It brings together leading researchers and professionals in the field of optics/optical engineering/optical materials and provides a platform to present and establish collaborations in this important area, with the theme “Trends in Electro-optics Instrumentation for Strategic Applications”. Topics covered but not limited to are Optical Engineering, Optical Thin Films, Optical Materials, IR Sensors, Image Processing & Systems, Photonic Band Gap Materials, Adaptive Optics, Optical Image Processing & Holography, Lasers, Fiber Lasers & its Applications, Diffractive Optics, Innovative packaging of Optical Systems, Nanophotonics Devices and Applications, Optical Interferometry & Metrology, Terahertz, Millimeter Wave & Microwave Photonics, Fiber, Integrated & Nonlinear Optics and Optics and Electro-optics for Strategic Applications.

Principles And Clinical Diagnostic Applications Of Surface Enhanced Raman Spectroscopy

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Author : Yuling Wang
language : en
Publisher: Elsevier
Release Date : 2021-09-17

Principles And Clinical Diagnostic Applications Of Surface Enhanced Raman Spectroscopy written by Yuling Wang and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-17 with Science categories.

Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. - Introduces the basics of SERS and suitable nanomaterials for SERS application - Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications - Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics

Biennial State Of The Art Sensors Technology In Australia 2019 2020

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Author : Edith Chow
language : en
Publisher: MDPI
Release Date : 2021-04-27

Biennial State Of The Art Sensors Technology In Australia 2019 2020 written by Edith Chow and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-27 with Science categories.

Recent developments in novel materials, sensing principles and signal processing are paving the way for new types of analytical sensors, offering improved sensing performance and practicality. Such advancements will provide accurate and real-time analytical information in the environmental, food, and healthcare sectors to better guide decision-making. For sensors to be commercially viable, the miniaturisation and integration of components for rapid, automated, in-field detection and diagnosis need to be considered. This book highlights state-of-the-art sensors technology in Australia through original contributions and reviews.

Surface Enhanced Raman Spectroscopy Biosensing And Diagnostic Technique For Healthcare Applications

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Author : Swati Jain
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-12-28

Surface Enhanced Raman Spectroscopy Biosensing And Diagnostic Technique For Healthcare Applications written by Swati Jain and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Science categories.

Surface enhanced Raman spectroscopy (SERS) is a technique applied in multidisciplinary research. Its use has tremendously grown in the last 40 years owing to improved nanofabrication, biomolecules extraction and sensitive signal acquisition techniques. This book focuses on the underlying principles of SERS by emphasizing on basic concepts and background information about the subject. Chapters explain the physics of Raman spectroscopy while also indicating its relevance to designing protocols and methodologies for biosensing and imaging. The book gives updated and recent details on colloids and nanostructures, their fabrication, surface engineering and immobilization methods, all in context to SERS based biosensing. Key Features: - Covers basic knowledge and new research about surface enhanced Raman spectroscopy (SERS) - Provides a complete framework on SERS based biosensing with concise chapters - Focuses on different active molecules critical to SERS and associated developed nanoassemblies - Presents information about ongoing research on SERS imaging applications - Highlights bottlenecks of SERS technique in biosensing - Includes references for further reading This book serves as a reference book for researchers and academicians and will also provide a reasonable understanding on the topic of SERS to newcomers irrespective of their background in a simple manner. The book is of interest to all readers within the scientific community involved with Raman spectroscopy, including chemists, physicists, biologists, material scientists as well as biomedical engineers.

Bionanotechnology For Advanced Applications

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Author : Ajaya Kumar Singh
language : en
Publisher: CRC Press
Release Date : 2024-03-08

Bionanotechnology For Advanced Applications written by Ajaya Kumar Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-08 with Technology & Engineering categories.

This book provides the fundamental aspects of bionanomaterials and bionanotechnology, and insight into the synthesis and modification of bionanomaterials in a detailed manner. It initiates with a general overview of biotechnology and nanotechnology followed by different strategies and methodologies for the synthesis of nanomaterials. Further, it discusses pertinent topics such as protein engineering, analysis, mechanisms of microbe- mediated nanosynthesis, followed by various challenges and innovation strategies, and the role of enzymes in bionanotechnology. Features: Covers the synthesis of bionanomaterials, including the interaction between nanomaterial and biogenic materials Encompasses the study of the connections between structure, molecular biology, and nanotechnology Explains several techniques (XRD, SEM, TEM, etc.) used for the analysis of bionanomaterials Includes prospects, challenges, and opportunities associated with bionanotechnology Reviews the interaction between nanomaterials and the biological system and self- assembly in bionanotechnology This book is aimed at graduate students and researchers in materials sciences, biotechnology, and bionanotechnology.

Metal Nanoparticles And Clusters

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Author : Francis Leonard Deepak
language : en
Publisher: Springer
Release Date : 2017-11-17

Metal Nanoparticles And Clusters written by Francis Leonard Deepak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-17 with Technology & Engineering categories.

​This book covers the continually expanding field of metal nanoparticles and clusters, in particular their size-dependent properties and quantum phenomena. The approaches to the organization of atoms that form clusters and nanoparticles have been advancing rapidly in recent times. These advancements are described through a combination of experimental and computational approaches and are covered in detail by the authors. Recent highlights of the various emerging properties and applications ranging from plasmonics to catalysis are showcased.

Miniaturized Analytical Devices

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Author : Suresh Kumar Kailasa
language : en
Publisher: John Wiley & Sons
Release Date : 2021-12-17

Miniaturized Analytical Devices written by Suresh Kumar Kailasa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-17 with Science categories.

Miniaturized Analytical Devices An in-depth overview of integrating functionalized nanomaterials with mass spectrometry, spectroscopy, electrophoresis, and other important analytical techniques Miniaturized Analytical Devices: Materials and Technology is an up-to-date resource exploring the analytical applications of miniaturized technology in areas such as clinical microbiology, pharmaceuticals, agriculture, and environmental analysis. The book covers the integration of functional nanomaterials in mass spectrometry, microscopy, electrophoresis, and more—providing the state-of-the-art information required for successfully implementing a range of chemical analysis techniques on microchips. Featuring contributions from a panel of international experts in the field, the book begins with an introduction to selected miniaturized devices, nanomaterials, and analytical methods. Subsequent sections describe functionalized nanomaterials (FNMs) for miniaturized devices and discuss techniques such as miniaturized mass spectrometry for bioassays and miniaturized microscopy for cell imaging. The book concludes by exploring a variety of applications of miniaturized devices in areas including metal analysis, bioimaging, DNA separation and analysis, molecular biology, and more. This timely volume: Surveys the current state of the field and provides a starting point for developing faster, more reliable, and more selective analytical devices Focuses on the practical applications of miniaturized analytical devices in materials science, clinical microbiology, the pharmaceutical industry, and environmental analysis Covers a wide range of materials and analytical techniques such as microvolume UV-VIS spectroscopy, microchip and capillary electrophoresis, and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) analysis Discusses the role of miniaturized analytical devices in securing a green and sustainable future Miniaturized Analytical Devices: Materials and Technology is essential reading for analytical chemists, analytical laboratories, materials scientists, biologists, life scientists, and advanced students in related fields.

Applied Raman Spectroscopy

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Author : Vivek Kumar Singh
language : en
Publisher: Elsevier
Release Date : 2025-03-17

Applied Raman Spectroscopy written by Vivek Kumar Singh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-17 with Science categories.

Applied Raman Spectroscopy: Concepts, Instrumentation, Chemometrics, and Life Science Applications synthesizes recent developments in the field, providing an updated overview. The book focuses on the modern concepts of Raman spectroscopy techniques, recent technological innovations, data analysis using chemometric methods, along with the latest examples of life science applications relevant in academia and industries. It will be beneficial to researchers from various branches of science and technology, and it will point them to modern techniques coupled with data analysis methods. In addition, it will help instruct new readers on Raman spectroscopy and hyphenated Raman spectroscopic techniques.The book is primarily written for analytical and physical chemistry students and researchers at a more advanced level who require a broad introductory overview of the applications of Raman spectroscopy, as well as those working in applied industry and clinical laboratories. Students, researchers, and industry workers in related fields, including X-ray and materials science, agriculture, botany, molecular biology and biotechnology, mineralogy, and environmental science will also find it very useful. - Provides a thorough discussion of the modern concepts and recent instrumental developments of Raman Spectroscopy in one resource - Presents comprehensive discussions on laser spectrometers, Raman Spectrometers, and detectors that can be used for apparatuses - Furnishes the latest updates on remote Raman spectroscopy in nanoscale optics, stimulated Raman microscopy and clinical as well as biomedical applications of surface-enhanced and tip-enhanced Raman spectroscopy - Covers the newest advances and capabilities of Raman-LIBS instruments, ranging from basic set-ups to more advanced configurations - Demonstrates updated chemometrics and numerical methods and shows the analytical capabilities of methods in terms of detection limits, accuracy, and precision of measurements for biological and environmental samples