Development Of A Generalized Process Model For Optimization Of Biotechnological Processes
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Development Of A Generalized Process Model For Optimization Of Biotechnological Processes
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Author : Simone Brüning
language : en
Publisher:
Release Date : 2017
Development Of A Generalized Process Model For Optimization Of Biotechnological Processes written by Simone Brüning and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Biopharmaceutical Processing
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Author : Gunter Jagschies
language : en
Publisher: Elsevier
Release Date : 2018-01-18
Biopharmaceutical Processing written by Gunter Jagschies and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Technology & Engineering categories.
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference
Digital Twins
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Author : Christoph Herwig
language : en
Publisher: Springer Nature
Release Date : 2021-05-27
Digital Twins written by Christoph Herwig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-27 with Technology & Engineering categories.
This is the first of two volumes that together provide an overview of the latest advances in the generation and application of digital twins in bioprocess design and optimization. Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing. In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them. This book explains the mathematical structure of digital twins, their development and the model’s respective parts, as well as concepts for the knowledge-driven generation and structural variability of digital twins. Covering fundamentals as well as applications, the two volumes offer the ideal introduction to the topic for researchers in academy and industry alike.
Modelling And Optimization Of Biotechnological Processes
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Author : Lei Zhi Chen
language : en
Publisher: Springer
Release Date : 2007-07-04
Modelling And Optimization Of Biotechnological Processes written by Lei Zhi Chen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-04 with Technology & Engineering categories.
Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods,inparticular,geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological processes.
Run To Run Optimization Of Biochemical Batch Processes In The Presence Of Model Plant Mismatch
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Author : Rubin Hille
language : en
Publisher:
Release Date : 2018
Run To Run Optimization Of Biochemical Batch Processes In The Presence Of Model Plant Mismatch written by Rubin Hille and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biochemical engineering categories.
An increased demand for novel pharmaceuticals such as recombinant proteins with therapeutic potential has lead to significant advances in the operation of biotechnological processes. In general, biochemical processes are characterized by nonlinear behavior and a sensitivity to environmental conditions. Furthermore, due to their complex operation, exposure to contamination and the low volume of the obtained product, these processes are generally still frequently operated in batch or fed-batch reactors. The repetitive nature of batch processes motivates the use of previous experimental effort to improve the performance of future batch operations. In this way, a so-called run-to-run optimization can be performed where the measurements of the current batch-run are utilized to determine the input for the next experiment. To conduct this step in a systematic and reliable manner, fundamental process models can be used for prediction and optimization purposes. This way, it is possible to determine the input for the next iteration from the predicted optimum obtained by calibrating a model based on measurements from the current batch-run. Fundamental models are typically derived from the underlying physical phenomena of the process. However, to make these models useful and tractable, it is common to make assumptions and simplifications during the model development. As a result, there often exists mismatch between the model and process under study. In the presence of model-plant mismatch, the set of model parameter estimates, which satisfy an identification objective, may not result in an accurate prediction of the gradients of the cost-function and constraints, which are essential for optimization. To still ensure convergence to the optimum, the method of simultaneous identification and optimization aims at forcing the predicted gradients to match the measured gradients by adapting the model parameters. At the same time, a correction factor is introduced into the model output so that the previously achieved fitting accuracy can be maintained. This results in a set of model parameters that reconcile the objectives of identification and optimization in presence of model-plant mismatch. Although the method provides the potential for dealing with structural error in iterative optimization schemes, there exist several challenges that have to be addressed before it is applicable to more complex systems. For example, when dealing with models containing a large number of parameters, it is unclear which parameters should be selected for calibration and adaptation. Since updating all available parameters is impractical due to estimability problems and over-fitting, there is a motivation for adapting only a subset of parameters. Furthermore, for this method to be more efficient under uncertainty, it is necessary to introduce additional robustness to uncertainty in initial conditions and gradient measurements. Finally, it is essential to develop experimental design criteria that will provide the user with more informative experiments to speed up convergence to the optimum and to calibrate the model with better accuracy. Following the above, this work presents the following new contributions: (i) An algorithmic approach to select a subset of parameters based on the sensitivities of the model outputs as well as of the cost function and constraint gradients. (ii) A run-to-run optimization formulation that is robust to uncertainties in initial batch conditions based on polynomial chaos expansions that are used to quantify the uncertainty and to propagate it onto the optimization cost. (iii) A modified parameter identification objective based on the minimization of the ratio of the sum of squared prediction errors to a parametric sensitivity measure to speed up convergence of the run-to-run procedure. (iv) The use of uncertainty bounds on the predicted trajectories to ensure model accuracy while solving the parameter identification problem described in item (iii) and to determine whether a model update is necessary at any given run. (v) The use of a design of experiments approach within the run-to-run optimization procedure to optimally complement the cost gradient information that is already available from previous batch experiments. The presented methods are shown to be efficient and facilitate the use of complex models for run-to-run optimization of batch processes. Several case studies of cell culture processes are presented to illustrate the improvements in robustness and performance. These case studies involve batch, fed-batch and perfusion operations. A part of this work has been developed in collaboration with an industrial partner whose main line of business is the development of perfusion growth media for mammalian cell culture operations.
Biotechnology Volume Ii
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Author : Horst W. Doelle
language : en
Publisher: EOLSS Publications
Release Date : 2009-11-16
Biotechnology Volume Ii written by Horst W. Doelle and has been published by EOLSS Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Biotechnology categories.
This Encyclopedia of Biotechnology is a component of the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Biotechnology draws on the pure biological sciences (genetics, animal cell culture, molecular biology, microbiology, biochemistry, embryology, cell biology) and in many instances is also dependent on knowledge and methods from outside the sphere of biology (chemical engineering, bioprocess engineering, information technology, biorobotics). This 15-volume set contains several chapters, each of size 5000-30000 words, with perspectives, applications and extensive illustrations. It carries state-of-the-art knowledge in the field and is aimed, by virtue of the several applications, at the following five major target audiences: University and College Students, Educators, Professional Practitioners, Research Personnel and Policy Analysts, Managers, and Decision Makers and NGOs.
Current Developments In Biotechnology And Bioengineering
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Author : Ashok Pandey
language : en
Publisher: Elsevier
Release Date : 2022-08-18
Current Developments In Biotechnology And Bioengineering written by Ashok Pandey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Technology & Engineering categories.
Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future. Covers state-of-the-art, technological advancements in the field of bioprocessing Includes design and scale-up of bioreactors, monitoring and control systems, advances in upstream and downstream processing Includes design and development of fermentation processes such as the suitability of experimental design, full factorial, central composite design, Box-Behnken, Plackett-Burman, and more
Biotechnology Volume Iv
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Author : Horst W. Doelle
language : en
Publisher: EOLSS Publications
Release Date : 2009-11-16
Biotechnology Volume Iv written by Horst W. Doelle and has been published by EOLSS Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Biochemical engineering categories.
This Encyclopedia of Biotechnology is a component of the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Biotechnology draws on the pure biological sciences (genetics, animal cell culture, molecular biology, microbiology, biochemistry, embryology, cell biology) and in many instances is also dependent on knowledge and methods from outside the sphere of biology (chemical engineering, bioprocess engineering, information technology, biorobotics). This 15-volume set contains several chapters, each of size 5000-30000 words, with perspectives, applications and extensive illustrations. It carries state-of-the-art knowledge in the field and is aimed, by virtue of the several applications, at the following five major target audiences: University and College Students, Educators, Professional Practitioners, Research Personnel and Policy Analysts, Managers, and Decision Makers and NGOs.
Continuous Biomanufacturing
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Author : Ganapathy Subramanian
language : en
Publisher: John Wiley & Sons
Release Date : 2017-12-26
Continuous Biomanufacturing written by Ganapathy Subramanian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-26 with Science categories.
This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.
Research In Computer Science In The Bulgarian Academy Of Sciences
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Author : Krassimir T. Atanassov
language : en
Publisher: Springer Nature
Release Date : 2021-07-19
Research In Computer Science In The Bulgarian Academy Of Sciences written by Krassimir T. Atanassov and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-19 with Technology & Engineering categories.
This book is a collection of papers devoted to the emergence and development in Bulgarian Academy of Sciences of some of the areas of informatics, including artificial intelligence. The papers are prepared by specialists from the Academy, some of whom are among the founders of these scientific and application areas in Bulgaria and in some cases – in the world. The book is interesting for specialists in informatics and computer science and researchers in history of sciences.