Development Of A Multi Functional Biopolymer Scaffold For Neural Tissue Engineering
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Development Of A Multi Functional Biopolymer Scaffold For Neural Tissue Engineering
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Author : Nicola Louise Francis
language : en
Publisher:
Release Date : 2013
Development Of A Multi Functional Biopolymer Scaffold For Neural Tissue Engineering written by Nicola Louise Francis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Biomedical engineering categories.
Advisor: Margaret A. Wheatley.
Porous Polymeric Bioresorbable Scaffolds For Tissue Engineering
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Author : Chiara Gualandi
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-07
Porous Polymeric Bioresorbable Scaffolds For Tissue Engineering written by Chiara Gualandi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-07 with Technology & Engineering categories.
The development and application of bioactive nano-structured constructs for tissue regeneration is the focus of the research summarised in this thesis. Moreover, a particular focus is the rational use of supercritical carbon dioxide foaming and electrospinning technologies which can lead to innovative polymeric bioresorbable scaffolds made of hydrolysable (both commercial and ‘ad-hoc’ synthesized) polyesters. Mainly, the author discusses the manipulation of polymer chemical structure and composition to tune scaffold physical properties, and optimization of scaffold 3D architecture by a smart use of both fabrication techniques. The multidisciplinary nature of this research is imperative in pursuing the challenge of tissue regeneration successfully. One of the strengths of this thesis is the integration of knowledge from chemistry, physics, engineering, materials science and biomedical science which has contributed to setting up new national and international collaborations, while strengthening existing ones.
Unfolding The Biopolymer Landscape
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Author : Viness Pillay
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-01-25
Unfolding The Biopolymer Landscape written by Viness Pillay and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-25 with Science categories.
The need for the development of biomaterials as scaffold for tissue regeneration is driven by the increasing demands for materials that mimic functions of extracellular matrices of body tissues. Unfolding the Biopolymer Landscape provides a unique account of “biopolymeric interventions” inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications. Chapters in this volume also cover biomedical applications and implications of cationic polymers, collagen-based substrates, multifunctional polymers, shape memory biopolymers, hybrid semisynthetic biomaterials, microbial exopolysaccharides, biomaterials mimicking the extracellular microenvironment, derivatized polysaccharides, and metallic biomaterials. Each chapter is distinctly written by experts in the respective fields and emphasis is given on the mechanistic profile of the performance of biopolymers and biomedical applications. This book provides both basic and advanced biopolymer information for scientific experts and early career researchers in the field of drug delivery, tissue engineering, nanomedicine, food technology, peptide science, biomaterial design, and nutrition. This volume provides a unique account of “biopolymeric interventions” inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications.
Biopolymer Composites In Electronics
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Author : Kishor Kumar Sadasivuni
language : en
Publisher: Elsevier
Release Date : 2016-09-10
Biopolymer Composites In Electronics written by Kishor Kumar Sadasivuni and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-10 with Technology & Engineering categories.
Biopolymer Composites in Electronics examines the current state-of-the-art in the electronic application based on biopolymer composites. Covering the synthesis, dispersion of fillers, characterization and fabrication of the composite materials, the book will help materials scientists and engineers address the challenges posed by the increased use of biopolymeric materials in electronic applications. The influence of preparation techniques on the generation of micro, meso, and nanoscale fillers, and the effect of filler size and dispersion on various biopolymers are discussed in detail. Applications covered include sensors, actuators, optics, fuel cells, photovoltaics, dielectrics, electromagnetic shielding, piezoelectrics, flexible displays, and microwave absorbers. In addition, characterization techniques are discussed and compared, enabling scientists and engineers to make the correct choice of technique. This book is a ‘one-stop’ reference for researchers, covering the entire state-of-the-art in biopolymer electronics. Written by a collection of expert worldwide contributors from industry, academia, government, and private research institutions, it is an outstanding reference for researchers in the field of biopolymer composites for advanced technologies. Enables researchers to keep up with the rapid development of biopolymer electronics, which offer light, flexible, and more cost-effective alternatives to conventional materials of solar cells, light-emitting diodes, and transistors Includes thorough coverage of the physics and chemistry behind biopolymer composites, helping readers to become rapidly acquainted with the fiel Provides in-depth information on the range of biopolymer applications in electronics, from printed flexible conductors and novel semiconductor components, to intelligent labels, large area displays, and solar panels
Freezing Colloids Observations Principles Control And Use
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Author : Sylvain Deville
language : en
Publisher: Springer
Release Date : 2017-01-19
Freezing Colloids Observations Principles Control And Use written by Sylvain Deville and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-19 with Technology & Engineering categories.
This book presents a comprehensive overview of the freezing of colloidal suspensions and explores cutting-edge research in the field. It is the first book to deal with this phenomenon from a multidisciplinary perspective, and examines the various occurrences, their technological uses, the fundamental phenomena, and the different modeling approaches. Its chapters integrate input from fields as diverse as materials science, physics, biology, mathematics, geophysics, and food science, and therefore provide an excellent point of departure for anyone interested in the topic. The main content is supplemented by a wealth of figures and illustrations to elucidate the concepts presented, and includes a final chapter providing advice for those starting out in the field. As such, the book provides an invaluable resource for materials scientists, physicists, biologists, and mathematicians, and will also benefit food engineers, civil engineers, and materials processing professionals.
Development Of Multiscale Electrospun Scaffolds For Promoting Neural Differentiation Of Induced Pluripotent Stem Cells
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Author : Nima Khadem Mohtaram
language : en
Publisher:
Release Date : 2014
Development Of Multiscale Electrospun Scaffolds For Promoting Neural Differentiation Of Induced Pluripotent Stem Cells written by Nima Khadem Mohtaram and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Electrospun biomaterial scaffolds can be engineered to support the neural differentiation of induced pluripotent stem cells. As electrospinning produces scaffolds consisting of nano or microfibers, these topographical features can be used as cues to direct stem cell differentiation. These nano and microscale scaffolds can also be used to deliver chemical cues, such as small molecules and growth factors, to direct the differentiation of induced pluripotent stem cells into neural phenotypes. Induced pluripotent stem cells can become any cell type found in the body, making them a powerful tool for engineering tissues. Therefore, a combination of an engineered biomaterial scaffold with induced pluripotent stem cells is a promising approach for neural tissue engineering applications. As detailed in this thesis, electrospun scaffolds support the neuronal differentiation of induced pluripotent stem cells through delivering the appropriate chemical cues and also presenting physical cues, specifically topography to enhance neuronal regeneration. This thesis seeks to evaluate the following topics: multifunctional electrospun scaffolds for promoting neuronal differentiation of induced pluripotent stem cells, neuronal differentiation of human induced pluripotent stem cells seeded on electrospun scaffolds with varied topographies, and controlled release of glial cell-derived neurotrophic factor from random and aligned electrospun nanofibers.
Engineering Polymeric Scaffolds For Studying Neural Tissue Development Pathology And Repair
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Author : Jacob Benjamin Schimelman
language : en
Publisher:
Release Date : 2023
Engineering Polymeric Scaffolds For Studying Neural Tissue Development Pathology And Repair written by Jacob Benjamin Schimelman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Digital light processing (DLP) 3D printing involves projecting a near-UV or visible light via an LED light source onto a digital micromirror device (DMD), which is the same device that is used in light projectors. I used this light-based bioprinting technique throughout my PhD work to develop hydrogel scaffolds to address pressing questions and challenges in in vitro neural tissue engineering and in vivo regenerative medicine applications. In Chapter 1, an overview of the development of biomaterials suited for light-based 3D-printing modalities with an emphasis on bioprinting applications is presented. The chemical mechanisms that govern photopolymerization are discussed, and the application of natural, synthetic, and composite biomaterials as 3D-printed hydrogels are highlighted. Since the quality of a 3D-printed construct is highly dependent on both the material properties and processing technique, the theoretical and practical aspects governing light-based 3D printing are also discussed. In Chapter 2, the development of a 3D printed in vitro optic nerve formation model is described. Hereditary and age-related optic nerve diseases as well as injuries can lead to vision loss and impairment which greatly reduces a person's quality of life. In development, the optic nerve is derived from axonal projections of retinal ganglion cells in the retina. There is an unmet need in ophthalmology for a complete visual circuit in vitro model to study formation, neurodegeneration, and function of the optic nerve. We have taken the first step to create the visual circuit in vitro by developing a 3D-printed microgroove hydrogel platform for guiding axonal outgrowth from iPSC-derived retinal ganglion cell (RGC) spheroids. In Chapter 3, the development of a 3D-printed conduit for functional recovery after a peripheral nerve injury is described. Many studies have explored different materials and active cues to guide neural regeneration, with some success. However, none have demonstrated a comparable or better functional recovery than the gold standard autograft. Autografts remain insufficient for full recovery from a large injury to the sciatic nerve or brachial plexus nerves. We have designed a 3D-printed hydrogel multi-microchannel conduits with and without orthogonal micropores to guide axonal outgrowth and external vascular integration, respectively, that perform as well as the gold standard autograft therapy.
Functional Materials From Carbon Inorganic And Organic Sources
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Author : Sanjay J. Dhoble
language : en
Publisher: Woodhead Publishing
Release Date : 2022-11-23
Functional Materials From Carbon Inorganic And Organic Sources written by Sanjay J. Dhoble and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Technology & Engineering categories.
Functional Materials from Carbon, Inorganic and Organic Sources: Methods and Advances describes the basic principles, mechanisms and theoretical background of functional materials. Sections cover Carbon-based functional materials, Inorganic functional materials for renewable and sustainable energy applications, and Organic and biological based functional materials. Applications such as energy storage and conversion, electronic and photonics devices, and in medicine are also explored. Sections dive into photovoltaic devices, light emitting devices, energy storage materials and quantum dot devices, solar cell fundamentals and devices, perovskite materials and ceramic thin films. Final sections emphasize green approaches to synthesis in semiconductor nanoparticles, quinolone complexes, biomaterials and biopolymers. Introduces the reader to a wide range of the most relevant functional materials, including carbon-based materials, inorganic materials for energy applications, and organic and biological based materials Reviews the synthesis and characterization methods used to create, optimize and analyze functional materials properties Discusses the use of functional materials to enable emerging technologies, along with remaining barriers to commercial adoption and opportunities
Development Of Neural Tissue Engineering Scaffolds For Guided Neurite Extension Within The Central Nervous System
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Author :
language : en
Publisher:
Release Date : 2009
Development Of Neural Tissue Engineering Scaffolds For Guided Neurite Extension Within The Central Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
This thesis reports on the development of two unique neural tissue engineering scaffolds for cellular support and guided neurite extension within the central nervous system (CNS). For this reason this work is presented in 3 Parts to allow for a thorough understanding to be obtained, in regard to the development and characterisation of each unique neural tissue engineering scaffold; Part I focuses on the development of nanoscale polymer fibres produced using electrospinning; Part II is concerned with the examination of smart xyloglucan hydrogels, which are injected into the body as a liquid and then assemble forming a hydrogel scaffold when the temperature is raised to 37 oC. Part III contains the final chapter and links the preceding Parts so that ultimately the benefits of each can be incorporated into a 'composite' scaffold. Such a scaffold may generate individual cellular niche environments that are more permissible for cell differentiation and maintenance or for directed axonal regeneration through mimicking some of the neurochemical and neuroanatomical architecture of physiological tissue.
Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds
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Author : Chong Wang
language : en
Publisher:
Release Date : 2017-01-27
Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds written by Chong Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with categories.
This dissertation, "Electrospun Multicomponent and Multifunctional Nanofibrous Tissue Engineering Scaffolds: Fabrication, Characteristics and Biological Performance" by Chong, Wang, 王翀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Electrospinning has attracted great attention in the fields of tissue engineering and controlled release of drugs/biomolecules. The aim of this project was to investigate electrospinning of nanofibers with core-shell structures using emulsion electrospinning, the formation of monolithic and core-shell structured nanofibrous drug/biomolecule delivery vehicles using polymers such as poly(D, L-lactic acid) (PDLLA) and poly(lactic-co-glycolic acid) (PLGA), and the formation of multicomponent bone tissue engineering scaffolds with angiogenic property, osteoinductivity and osteoconductivity. The foundation of this project was laid by investigating monocomponent scaffolds. First, effects of properties of polymer solutions and water-in-oil (w/o) emulsions and electrospinning parameters on the morphology, diameter and structure of fibers were systematically investigated. Second, drugs (vancomycin and rifamycin) and a model protein (bovine serum albumin) were incorporated in monolithic or core-shell nanofibers via blend electrospinning or emulsion electrospinning to form single or dual delivery systems, providing fundamental understandings. Growth factors such as recombinant human bone morphogenetic protein-2 (rhBMP-2) and basic-fibroblast growth factor (b-FGF) were then incorporated in PLGA or PDLLA nanofibrous delivery vehicles. The in vitro release behaviour of drugs and biomolecules was studied. Third, calcium phosphate (Ca-P) nanoparticles were synthesized and used for fabricating Ca-P/PLGA and Ca-P/PDLLA nanocomposite scaffolds. Homogeneous distribution of Ca-P in fibrous scaffolds could be achieved. With the assistance of emulsion electrospinning and nanocomposite electrospinning, bicomponent scaffolds containing rhBMP-2 and Ca-P nanoparticles were fabricated using dual-source dual-power electrospinning. The fibrous component ratio could be varied by using multiple syringes for electrospinning fibers. The structure and properties, including in vitro release behaviour, of mono- and bicomponent scaffolds were studied in detail. Tricomponent scaffolds incorporated with recombinant human vein endothelial growth factor (rhVEGF), rhBMP-2 and Ca-P nanoparticles were subsequently fabricated using multi-source dual-power electrospinning. To achieve a sequential release of firstly rhVEGF and then rhBMP-2, PLGA/polyethylene glycol (PEG) blends and PLGA were used for incorporating rhVEGF and rhBMP-2, respectively. For tricomponent scaffolds with different component ratios, different release amounts but similar release profiles could be achieved for the growth factors. In vitro biological investigations were conducted for mono-, bi- and tricomponent scaffolds. Pre-osteoblast cells (MC3T3-E1) were found to attach, spread, proliferate and express alkaline phosphatase (ALP) activity on rhBMP-2 and Ca-P nanoparticle incorporated bicomponent scaffolds. Calcium deposition was also observed in cells cultured with bicomponent scaffolds. Human umbilical vein endothelial cells (HUVECs) were found to attach, spread, proliferate on tricomponent scaffolds and rhVEGF released from mono-, bi- and tricomponent scaffolds could facilitate cell proliferation and migration, indicating released rhVEGF could promote angiogenesis. C3H10T1/2 cell line and human bone marrow derived mesenchymal stem cells (hBMSCs) were found to attach, spread and proliferate o